Could a common antibiotic replace vancomycin in heart surgery?

NCT ID NCT07267013

Recruiting now Knowledge-focused Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether clindamycin, an antibiotic already used in other surgeries, can be a safe and effective alternative to vancomycin for preventing infections in patients undergoing aortic heart surgery with a heart-lung machine. The trial will enroll 25 adults and measure clindamycin levels in the blood during surgery to ensure it stays high enough to kill bacteria. It aims to address the need for better options for patients allergic to standard antibiotics.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Clindamycin
What this could lead to: If successful, this could provide a safer, easier-to-use antibiotic option for heart surgery patients who are allergic to penicillin.
What could go wrong: This is a very small, early-phase study (25 people) focused on drug levels, not on preventing infections. It may not prove clindamycin works as well as current options.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC SURGERY EXTRACORPOREAL CIRCULATION

Contacts and locations

Locations

CHU Nantes
RECRUITING

Nantes, France, 44000, France

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