Could a common antibiotic replace vancomycin in heart surgery?
NCT ID NCT07267013
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether clindamycin, an antibiotic already used in other surgeries, can be a safe and effective alternative to vancomycin for preventing infections in patients undergoing aortic heart surgery with a heart-lung machine. The trial will enroll 25 adults and measure clindamycin levels in the blood during surgery to ensure it stays high enough to kill bacteria. It aims to address the need for better options for patients allergic to standard antibiotics.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Clindamycin
What this could lead to
If successful, this could provide a safer, easier-to-use antibiotic option for heart surgery patients who are allergic to penicillin.
What could go wrong
This is a very small, early-phase study (25 people) focused on drug levels, not on preventing infections. It may not prove clindamycin works as well as current options.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHU Nantes
RECRUITINGNantes, France, 44000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••