Diet before surgery may cut pain and opioid use, new trial hopes to prove
NCT ID NCT04219956
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether eating a diet very low in polyamines (natural compounds found in many foods) for a week before and after major abdominal surgery can lower pain levels. Researchers will compare pain scores and painkiller use in 278 adults who either follow the special diet or eat normally. The goal is to see if this simple dietary change can reduce the need for strong pain medications like morphine.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
polyamine-deficient diet
What this could lead to
If it works, this diet could offer a simple, drug-free way to reduce pain and opioid use after major abdominal surgery.
What could go wrong
This is an early-stage trial with no prior proof that a low-polyamine diet affects pain. The diet is restrictive and may be hard to follow. Results may not apply to other surgeries.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHD Vendée
RECRUITINGLa Roche-sur-Yon, France
Contact
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CHRU Brest La Cavale Blanche
RECRUITINGBrest, France
Contact
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CHU Nantes Hôtel Dieu
RECRUITINGNantes, France
Contact
Contact
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Hôpital Louis Mourier from Ap-HP
RECRUITINGColombes, 92700, France
Contact Email: •••••@•••••