Diet before surgery may cut pain and opioid use, new trial hopes to prove
NCT ID NCT04219956
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether eating a diet very low in polyamines (natural compounds found in many foods) for a week before and after major abdominal surgery can lower pain levels. Researchers will compare pain scores and painkiller use in 278 adults who either follow the special diet or eat normally. The goal is to see if this simple dietary change can reduce the need for strong pain medications like morphine.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- polyamine-deficient diet
- What this could lead to
- If it works, this diet could offer a simple, drug-free way to reduce pain and opioid use after major abdominal surgery.
- What could go wrong
- This is an early-stage trial with no prior proof that a low-polyamine diet affects pain. The diet is restrictive and may be hard to follow. Results may not apply to other surgeries.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHD Vendée
RECRUITINGLa Roche-sur-Yon, France
-
CHRU Brest La Cavale Blanche
RECRUITINGBrest, France
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CHU Nantes Hôtel Dieu
RECRUITINGNantes, France
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Hôpital Louis Mourier from Ap-HP
RECRUITINGColombes, 92700, France
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