Partial thymectomy may shield infant immunity after heart surgery

NCT ID NCT07019857

Recruiting now Knowledge-focused Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at infants having heart surgery, where the thymus gland is often fully removed to access the heart. The thymus helps build the immune system early in life. Researchers want to see if removing only part of the thymus keeps the immune system stronger and reduces infections. They will compare blood tests and infection records over one year in three groups: complete removal, partial removal, and no removal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could guide surgeons to preserve part of the thymus during infant heart surgery, potentially reducing infection risks and improving immune health.
What could go wrong: This is a small, single-center observational study, not a treatment trial. It only measures immune markers and infection rates, so it cannot prove that partial thymectomy directly causes better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

congenital heart disease inborn error of immunity Infections

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL HEART DEFECTS IMMUNOLOGICAL DEFICIENCY SYNDROME THYMECTOMY

Contacts and locations

Locations

CHU de Nantes
NOT_YET_RECRUITING

Nantes, 44093, France
Chu de Nantes
RECRUITING

Nantes, 44093, France

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