DNA hunt for heart defect clues: 2,000 families sought

NCT ID NCT02432079

Recruiting now Knowledge-focused Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to collect DNA samples and medical information from 2,000 people with heterotaxy (a condition where organs are arranged abnormally) and related heart defects, along with their family members. Researchers hope to identify the genetic causes of these conditions, which could improve genetic counseling and our understanding of how the body develops left-right asymmetry. Participants provide samples and data but receive no direct treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better genetic testing and counseling for families affected by heterotaxy and related heart defects.
What could go wrong: This is an observational study, not a treatment trial. It may take years to yield actionable results, and findings may not apply to all cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Abnormalities, Multiple Cardiovascular Abnormalities cardiovascular disorder Congenital Abnormalities congenital heart disease dextrocardia heart disorder Heterotaxy Syndrome situs inversus splenic disorder visceral heterotaxy volvulus of midgut

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL HEART DEFECTS HETEROTAXY SYNDROME

Contacts and locations

Locations

Indiana University School of Medicine
RECRUITING

Indianapolis, Indiana, 46202, United States

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