Massive gene hunt aims to unlock secrets of heart birth defects

NCT ID NCT01196182

Ongoing Knowledge-focused Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is collecting DNA and health information from 32,000 people with congenital heart defects. Researchers hope to find genetic causes and understand why outcomes vary. No treatment is being tested—this is a research study to gather knowledge.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could reveal genetic causes of congenital heart defects and help predict outcomes, guiding future treatments.
What could go wrong: This is an observational study, not a treatment trial. It may not directly benefit participants, and findings may take years to apply.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

congenital heart disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL HEART DEFECTS

Contacts and locations

Locations

Brigham & Women's Hospital

Boston, Massachusetts, 02115, United States
Children's Healthcare of Atlanta

Atlanta, Georgia, 30342, United States
Children's Hospital Boston

Boston, Massachusetts, 02115, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Cohen Children's Medical Center New York

New Hyde Park, New York, 11040, United States
Columbia University Medical Center

New York, New York, 10032, United States
Mount Sinai School of Medicine

New York, New York, 10029, United States
Stanford University

Palo Alto, California, 94304, United States
University College London

London, WC1N3JH, United Kingdom
University of California, San Francisco

San Francisco, California, 94158, United States
University of Michigan Health

Ann Arbor, Michigan, 48109, United States
University of Rochester

Rochester, New York, 14642, United States
University of Utah

Salt Lake City, Utah, 84113, United States
Yale University

New Haven, Connecticut, 06520, United States

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