Could argon gas help comatose cardiac arrest patients?

NCT ID NCT05482945

Recruiting now Disease control Sponsor: Mario Negri Institute for Pharmacological Research Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial tests whether breathing a mix of argon gas and oxygen soon after a cardiac arrest can reduce brain damage. Researchers will enroll 120 comatose patients who were resuscitated from a witnessed cardiac arrest. The main goal is to see if argon lowers a brain injury marker in the blood, with additional checks on heart damage, brain scans, and survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Argon gas (mixed with oxygen)
What this could lead to: If it works, this could point toward a simple, safe way to protect the brain and heart after cardiac arrest, improving recovery and survival.
What could go wrong: This is a mid-stage trial with only 120 patients. Argon's benefits seen in animals may not translate to humans, and the primary outcome is a biomarker, not long-term function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ARREST WITH SUCCESSFUL RESUSCITATION CARDIAC ARREST, OUT-OF-HOSPITAL

Contacts and locations

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Study contacts

Contact

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Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Arcispedale Santa Maria Nuova di Reggio Emilia
NOT_YET_RECRUITING

Reggio Emilia, Reggio Emilia, 42123, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••
Azienda Ospedaliero - Universitaria di Parma
NOT_YET_RECRUITING

Parma, Parma, 43126, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••
Azienda Sanitaria Universitaria Giuliano Isontina (Asugi) di Trieste
RECRUITING

Trieste, TS, 34148, Italy

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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
RECRUITING

Milan, Milan, 20122, Italy

Contact Email: •••••@•••••
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, RM, 00168, Italy

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Ospedale Civile Santa Maria degli Angeli di Pordenone
RECRUITING

Pordenone, Pordenone, 33170, Italy

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Ospedale Policlinico San Martino di Genova
RECRUITING

Genova, GE, 16132, Italy

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Ospedale San Gerado
RECRUITING

Monza, MB, 20900, Italy

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Ospedale Santa Chiara di Trento
RECRUITING

Trento, Trento, 38122, Italy

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