Mario Negri Institute For Pharmacological Research

This study is testing if a medication called patiromer can allow people on long-term dialysis to relax their very strict low-potassium diets. The goal is to see if patients can eat more normally without their blood potassium getting dangerously high, which could improve their qua…

This study is testing whether radiation followed by two drugs (durvalumab and ceralasertib) can help control lung cancer that has returned in the chest area after previous treatment. The trial is for stage III non-small cell lung cancer patients whose cancer progressed despite re…

This study is testing whether adding argon gas to oxygen during ventilation can help protect the brain and heart in people who have been successfully resuscitated from an out-of-hospital cardiac arrest. The goal is to see if this treatment reduces brain damage and improves surviv…

This trial is testing whether a supplement called acetyl-L-carnitine can slow the progression of ALS (Lou Gehrig's disease). Researchers will enroll 246 people with early-stage ALS to receive either the supplement or a placebo for 48 weeks, in addition to their standard medicatio…

This study aims to develop and test a new diagnostic tool using RNA sequencing (RNA-Seq) to find the genetic causes of rare diseases. It will enroll about 105 participants, including healthy people, patients with known diagnoses, and patients who remain undiagnosed after standard…

This study is testing whether adding specific omega-3 fats to your diet can help reduce chronic inflammation, a key driver of heart disease. Researchers will enroll 324 adults over 55 who are at moderate to high risk for heart problems. Participants will follow one of three diets…

This study aims to develop and test new, advanced ultrasound scanning methods specifically for imaging blood vessels in the arm and neck that supply the brain. Researchers will scan 60 healthy volunteers to collect detailed measurements and establish normal reference ranges for v…

This study aims to check if different 1.5T MRI machines produce consistent measurements when scanning healthy kidneys. Researchers will scan 48 healthy volunteers at multiple centers to see if results are reproducible across machines and if age or sex affects measurements. The go…

This study aims to understand how rare genetic mutations cause atypical Hemolytic Uremic Syndrome (aHUS), a serious blood disorder that damages kidneys. Researchers will study cells from 112 patients with aHUS to learn how specific gene defects affect blood vessel function. The g…

This study aims to understand how well patients with a specific kidney disease called primary membranous nephropathy do when treated with antibody medications like rituximab in real-world settings. Researchers will follow 500 adult patients who have this disease with significant …

This study aims to understand why some patients with a kidney disease called membranous nephropathy get better with a specific treatment while others do not. Researchers will closely examine the immune cells of 86 patients and healthy volunteers before and after treatment. The go…

This study investigates whether sounds coming from dialysis fistulas can reveal problems with blood flow. Researchers will record sounds from 15 patients with kidney failure who need new dialysis access and compare them to detailed blood flow measurements. The goal is to understa…

This study aims to understand a specific type of kidney disease called idiopathic nephrotic syndrome by measuring certain antibodies in the blood. Researchers will analyze stored blood samples from 100 adults who have this condition, including some whose disease returned after a …