Mario Negri Institute For Pharmacological Research

This study is for people with stage III lung cancer whose tumor has come back in the chest after previous treatment with chemotherapy, radiation, and the drug durvalumab. Participants will receive targeted radiation to the tumor, followed by two drugs: durvalumab (an immunotherap…

This study follows 500 adults with primary membranous nephropathy, a kidney disease that causes protein leakage and swelling. Researchers will track how well patients respond to treatments like rituximab or other monoclonal antibodies in real-world settings. The goal is to unders…

This study tests whether giving argon gas to people who have been resuscitated after a cardiac arrest can reduce brain injury. Researchers will measure a brain damage marker in the blood and use MRI scans. The trial involves 120 adults who are unconscious after a witnessed cardia…

This study tests a drug called patiromer in 40 adults on dialysis who must limit potassium-rich foods like bananas and potatoes. The goal is to see if patiromer can safely allow patients to relax their strict low-potassium diet, improving their quality of life and nutrition. Part…

This study tests whether adding omega-3 fatty acids from fish oil or camelina oil to the diet can improve a blood-based risk score for heart disease. About 324 adults over 55 at moderate to high cardiovascular risk will take one of three diets for 12 weeks: fish oil, plant oil, o…

This study tests whether acetyl-L-carnitine, a natural substance, can slow the loss of self-sufficiency in people with ALS. About 246 adults with early-stage ALS will receive either a low or high dose of the supplement or a placebo, alongside standard care. Researchers will track…

This study looks at how repeatable kidney MRI measurements are when using 1.5T scanners. It involves 48 healthy adults aged 18-70 with normal kidney function. The goal is to improve the accuracy of kidney imaging for future research and diagnosis.

This study looks at people with atypical hemolytic uremic syndrome (aHUS), a rare kidney disease. Researchers want to understand how certain rare gene mutations affect the disease. They will grow cells from patients and healthy donors in the lab to study them. The goal is to find…

This study looks at blood samples from 100 adults with a kidney condition called nephrotic syndrome. Researchers want to measure levels of certain immune markers (anti-nephrin autoantibodies) to see if they differ between types of the disease. The goal is to better understand the…

This study is testing new ultrasound techniques to get detailed images and measurements of blood vessels in the arm and neck. Researchers will examine 60 healthy adults aged 18 to 75 to establish normal ranges for vessel size, flow, and stiffness. The goal is to improve future di…

This study aims to improve diagnosis for people with rare genetic diseases that standard DNA tests cannot identify. Researchers will use RNA sequencing on skin cells from 105 participants, including healthy volunteers and patients with known or suspected genetic conditions. The g…

This study looks at whether the sound made by an arteriovenous fistula (a surgically created connection between an artery and a vein used for dialysis) can tell doctors about blood flow conditions inside it. Researchers will measure sound patterns and compare them to ultrasound i…