Mario Negri Institute For Pharmacological Research

This study tested whether adding pioglitazone (a diabetes drug) to trabectedin (a chemotherapy) can better control liposarcoma, a rare soft-tissue cancer. Ten adults whose tumors had stopped growing on trabectedin alone received the combination. The goal was to see if the combo c…

This completed study tested whether programs involving schools and families could help prevent childhood obesity in 226 children aged 6 to 11. Researchers measured children's weight, diet quality, and family habits to see if these programs encouraged healthier lifestyles. The goa…

This study looked at blood samples from 48 people with membranous nephropathy, a kidney disease, to see how treatments that deplete B-cells affect specific immune cells linked to the disease. Researchers tracked these cells over time in patients who got better, relapsed, or didn'…

This study examined 10 people with autosomal dominant polycystic kidney disease (ADPKD) to see if a specific missing piece in the PKD2 gene is shared among families in the Bergamo area. Researchers collected medical histories and DNA samples to understand how this gene change aff…