Mario Negri Institute For Pharmacological Research

This study tests a drug called obinutuzumab in 10 adults with a kidney condition called nephrotic syndrome that keeps coming back despite standard treatments. The goal is to see if a single course can prevent relapses for at least 12 months and reduce the need for repeated rituxi…

This study tests a new approach for women with a common type of early breast cancer (HR+/HER2-). Instead of standard chemotherapy before surgery, some participants may receive a combination of hormone therapy and a targeted drug (abemaciclib) based on a gene test result from thei…

This study tests a new wearable device that listens to the sounds of blood flow in the arm of people on hemodialysis. The goal is to see if the device can accurately monitor the health of the vascular access (the connection used for dialysis). Six adults with mature fistulas will…

This study looks at stored blood and kidney samples from 120 people with membranous nephropathy, a kidney disease, to find genetic and protein markers that can predict who will respond well to a specific treatment called rituximab. The goal is to help doctors choose the best trea…

This study aims to understand how SGLT2i medications protect the kidneys in people with diabetic kidney disease who are at risk of worsening. Researchers will use advanced MRI scans and blood tests to measure kidney function, blood flow, and other markers in 100 participants. The…