Mario Negri Institute For Pharmacological Research

This study is testing if some patients with a common type of early breast cancer can avoid chemotherapy before surgery. Instead, they would receive a targeted pill (abemaciclib) plus hormone therapy. The goal is to see if this gentler approach works as well for shrinking tumors, …

This trial is testing whether a drug called obinutuzumab can help adults with a specific type of kidney disease (idiopathic nephrotic syndrome) that keeps coming back and currently depends on another drug, rituximab. The study will enroll 10 adult participants to see if obinutuzu…

This study is testing a new wearable device designed to monitor the health of a dialysis patient's vascular access (AVF). The device listens to the sounds of blood flow to detect early signs of problems like narrowing or blockage. The goal is to see if this simple, wearable metho…

This study aims to help doctors predict which patients with a kidney disease called membranous nephropathy will respond well to a common treatment called rituximab. Researchers will analyze stored blood and tissue samples from 120 patients to look for genetic and molecular marker…

This study aims to understand why and how certain diabetes medications (SGLT2 inhibitors) protect the kidneys. Researchers will use detailed MRI scans and blood tests on 100 adults with diabetic kidney disease who are already taking these medications. The goal is to find better w…