Mario Negri Institute For Pharmacological Research

This phase IV trial tests whether the drugs olaparib and bevacizumab, taken together after initial chemotherapy, can help prevent ovarian cancer from coming back in women with a specific genetic marker (HRD-positive). About 190 participants who have already responded to first-lin…

This study looks at 75 kidney transplant patients to compare two different drug combinations given right after transplant. One group gets a single dose of RATG plus basiliximab, while the other gets seven doses of RATG plus basiliximab. The goal is to see which approach causes fe…

This study looks at a new method called Fenice to measure how crowded an emergency room is. Researchers will compare it to the opinions of healthcare workers and an older method called NEDOCS. About 828 patients in multiple hospitals will take part. The goal is to see if the new …

This study looks at whether patients admitted to the emergency room truly need to be there. Researchers will create and test a computer algorithm using data from 1,200 adults with chest pain, belly pain, shortness of breath, or fainting. The goal is to improve the quality of emer…

This study aims to create and test a computer algorithm that can tell if a patient's admission to the hospital from the emergency department was medically appropriate. Researchers will analyze data from 1,200 adults who came to the ER with chest pain, belly pain, shortness of bre…

This study aims to develop better lab tests to diagnose and monitor two rare kidney diseases: atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). Researchers will analyze blood, cells, and kidney tissue from 180 patients and healthy volunteers to find markers t…

This observational study reviews medical records from 70 adults with advanced autosomal dominant polycystic kidney disease (ADPKD) who are already taking the drug octreotide LAR. Researchers want to see if baseline kidney volume and other factors can predict how quickly kidney fu…

This observational study compares two common blood tests—creatinine and cystatin C—to see which one better estimates actual kidney function in people with nephrotic syndrome. Researchers will use stored blood samples from 50 participants in three ongoing clinical trials. The goal…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…

This study looks at whether artificial intelligence can create realistic, privacy-safe copies of health records from people with a rare kidney disease called ADPKD. Researchers will use these simulated datasets to run virtual clinical trials and see if they produce similar result…