Mario Negri Institute For Pharmacological Research

This study tests whether omega-3 fatty acids from fish oil or camelina oil can reduce inflammation and improve heart health in 324 adults over 55 at moderate to high cardiovascular risk. Participants take daily supplements for 12 weeks, and researchers measure changes in blood ma…

This phase 2 trial is testing whether giving radiotherapy followed by two drugs—durvalumab (an immunotherapy) and ceralasertib (a targeted therapy)—can help people with stage III non-small cell lung cancer whose cancer has returned in the chest after standard treatment. The study…

This study tests whether acetyl-L-carnitine (ALCAR), a natural supplement, can slow the loss of self-sufficiency in people with ALS. About 246 adults with early-stage ALS will receive either a low or high dose of ALCAR or a placebo for 48 weeks, alongside standard care. Researche…

This phase 2 trial tests whether breathing a mix of argon gas and oxygen soon after a cardiac arrest can reduce brain damage. Researchers will enroll 120 comatose patients who were resuscitated from a witnessed cardiac arrest. The main goal is to see if argon lowers a brain injur…

This study tests whether the drug patiromer can safely allow people on chronic dialysis to relax their strict low-potassium diet. About 40 participants will receive either patiromer or a placebo daily. The goal is to see if patiromer keeps potassium levels stable while patients e…

This study looks at whether measuring certain antibodies in the blood can help diagnose and monitor idiopathic nephrotic syndrome, a kidney condition that causes swelling and protein loss. Researchers will test blood samples from 100 adults with different forms of the disease and…

This study aims to create a system for continuously evaluating healthcare quality in semi-intensive care units. Researchers will track outcomes like transfers to intensive care or death in the hospital for 39,000 patients. The goal is to identify areas for improvement and enhance…

This study is developing and testing a computer algorithm that uses hospital data to see if emergency room doctors are making the right choices about whether to admit patients to the hospital or send them home. Researchers will ask doctors and nurses for their input to refine the…

This study looks at how doctors decide to use brain CT scans for people with mild head injuries in emergency rooms. Many CT scans come back normal, exposing patients to unnecessary radiation and increasing costs. Researchers will analyze data from 2,500 adults across Italy to und…

This study aims to create three different dashboards for emergency departments: one for citizens to help them decide where to go for care, one for healthcare workers to track patient flow, and one for policymakers to monitor crowding and disease trends. Researchers will observe 1…

This study is developing a language model to read and interpret electronic medical records from emergency departments. Researchers will check if the model can accurately extract information from 300,000 patient records. The goal is to create a tool that helps doctors and scientis…

This study looks at why some emergency departments in Europe admit more patients than others, even for similar symptoms. Researchers will analyze data from over 162,000 adults who visited the ER with shortness of breath or fainting between 2021 and 2023. The goal is to create a m…

This study aims to improve diagnosis for people with rare genetic diseases whose standard genetic tests came back negative. Researchers will take a small skin sample and analyze RNA to find hidden genetic changes. The study involves 105 participants, including healthy volunteers …

This observational study follows 500 adults with primary membranous nephropathy and nephrotic syndrome who are treated with rituximab or other monoclonal antibodies. Researchers aim to describe long-term disease outcomes and identify predictors of remission or progression. The st…

This study is investigating why some people with membranous nephropathy, a kidney disease, respond well to a treatment that depletes certain immune cells (B-cells) while others do not. Researchers will analyze blood samples from 86 patients and healthy volunteers to compare immun…

This study looks at people with atypical hemolytic uremic syndrome (aHUS), a rare disease that damages small blood vessels and kidneys. Researchers want to understand how certain rare gene mutations cause the disease by growing cells from blood samples in the lab. The goal is to …

This study looks at whether the sounds made by blood flowing through an arteriovenous fistula (AVF) can tell doctors how healthy the fistula is. Researchers will use MRI and ultrasound to measure blood flow and compare it to the sounds recorded. If a clear link is found, it could…

This study uses an advanced ultrasound machine to test new ways of measuring blood vessels in the arm and neck. Researchers will scan 60 healthy adults aged 18 to 75 to set normal ranges and check if the measurements are repeatable. The goal is to improve future diagnosis of kidn…

This study is testing how consistently kidney MRI scans work on standard 1.5T machines. It involves 48 healthy volunteers who will undergo repeated MRI scans to measure kidney size, blood flow, and oxygen levels. The goal is to make kidney MRI a reliable tool for diagnosing disea…