Could a diabetes drug ease chest pain in women with hidden heart disease?
NCT ID NCT06600178
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a drug called Brezavvy (an SGLT2 inhibitor) can improve blood flow in the tiny vessels of the heart and reduce chest pain in women who have angina but no blocked major arteries. 150 women will take either the drug or a placebo for 12 weeks and undergo heart scans and questionnaires. The goal is to see if this treatment can help manage a condition that often goes undiagnosed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Brezavvy (SGLT2 inhibitor)
- What this could lead to
- If successful, this could point toward a new treatment option for women with chest pain caused by small heart vessel problems, improving their quality of life.
- What could go wrong
- This is an early Phase 1 trial with only 150 participants, so results may not apply to everyone. The drug may not improve symptoms or could have side effects not yet known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ANGINA PATIENTS WITH NON-OBSTRUCTIVE CORONARY ARTERY DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
UVA Health
RECRUITINGCharlottesville, Virginia, 22908, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could High-Intensity workouts and diet tame chest pain from tiny heart vessels?
- Can a new tracer match the gold standard for heart scans?
- Can an Hourglass-Shaped device relieve chest pain when arteries Aren't blocked?
- Microplastics in your blood: a hidden heart risk?
- Can a diabetes drug unclog the Heart's tiny vessels?
- Lifting weights, lifting hearts: can resistance training soothe angina in women?