BREAST CANCER FEMALE

This study looks at whether women with aggressive breast cancers (triple-negative or HER2-positive) who have a complete response to chemotherapy can safely avoid sentinel lymph node biopsy. The trial enrolls 350 patients across Europe and will track cancer recurrence in the armpi…

This study compares a robotic surgical system (da Vinci SP) to traditional open surgery for nipple-sparing mastectomy in women with early-stage breast cancer. About 204 participants will be randomly assigned to one of the two procedures to see which is safer and more effective. T…

This study tests a new drug called azenosertib combined with two standard chemotherapy drugs (carboplatin and pembrolizumab) in people with metastatic triple-negative breast cancer. The goal is to find the safest dose and see if the combination shrinks tumors. About 78 adults wit…

This study is for post-menopausal women with a common type of breast cancer that has a high chance of coming back. Participants receive either standard hormone therapy alone or with an added drug called abemaciclib. The goal is to see if the combination delays or prevents cancer …

This study tests whether giving two drugs (taxotere and trastuzumab) before surgery can eliminate all signs of invasive cancer in Nigerian women with HER2-positive breast cancer. About 53 women with stage II or III breast cancer who have not had prior chemotherapy will receive th…

This study tests a combination of two drugs, sacituzumab govitecan and trastuzumab, in 28 people with HER2+ breast cancer that has spread and has been previously treated. The goal is to see if this combination can shrink tumors or slow cancer growth. Participants receive both dru…

This study looks at whether a combination of ribociclib (a targeted drug) and hormone therapy can help women with intermediate-risk, hormone receptor-positive, HER2-negative early breast cancer better than standard chemotherapy. About 1,684 women will take part. The goal is to se…

This study is for women with a common type of breast cancer (HR+/HER2-) who have a high chance of the cancer returning after initial treatment. It tests whether adding the drug abemaciclib to standard hormone therapy works better than hormone therapy alone to prevent cancer from …

This study tests whether adding the targeted drug pyrotinib to standard chemotherapy and trastuzumab before surgery can completely eliminate tumors in women with early-stage HER2-positive breast cancer. About 53 women with stage II to III breast cancer will receive the combinatio…

This study looks at a new material called SC Derm, used in breast reconstruction after mastectomy for breast cancer. About 120 women will receive either SC Derm or another standard material. The goal is to see if SC Derm leads to fewer complications and better cosmetic results.

This study is testing a new way to screen for breast cancer using a laser analysis of a blood sample (liquid biopsy). Researchers will compare results from 1,100 women—some with early-stage breast cancer and some without—to see if the laser test can accurately detect cancer. If s…

This study looks at whether a special type of mammogram using a contrast dye can find breast cancer more accurately than standard mammograms in women who have already had breast cancer. About 1,647 women will get both types of imaging to compare how many cancers are found and how…

This study tests two vaccines designed to prevent breast cancer from returning in people who have already been treated for HER2-positive breast cancer. About 119 participants who had chemotherapy and surgery but still had cancer cells left will receive one of the vaccines. The go…

This study tests an internet-delivered program called SHINE to help breast cancer survivors manage sexual concerns after treatment. About 340 women who finished primary cancer treatment at least 12 weeks ago will take part. Participants receive online education and tools over 12 …

This study aims to create and test a shortened mindfulness program to help older African American women who have had breast cancer feel less depressed. About 23 women aged 65 and older with mild to moderate depression will take part. The goal is to see if the program is practical…

This study looks at 100 women with breast or gynecological cancer to see if their diet before starting chemotherapy affects levels of a protein called hepcidin. Researchers want to know if hepcidin levels are linked to how much of the planned chemotherapy dose patients actually r…

This study looks at whether taking hormone therapy for 3 months before breast cancer surgery helps women aged 65 and older with early-stage, hormone-sensitive breast cancer decide if they want radiation after surgery. About 84 participants will take the medication and report how …

This study looks at how breast cancer itself (before any treatment) might affect a woman's eggs and ability to preserve fertility. Researchers will compare egg quality and hormone responses between 100 women with breast cancer and healthy egg donors. The goal is to understand why…

This study is a registry that follows women aged 50 and older with early-stage, low-risk breast cancer who receive a single dose of radiation during their lumpectomy surgery (IORT). The goal is to track how often the cancer comes back and monitor side effects, quality of life, an…

This study looks at why some women disagree with their personal breast cancer risk estimate given during mammogram screening. Researchers will survey 750 women aged 39-74 to understand how they react to their risk score and whether it affects their screening plans. The goal is to…

This study tests two methods to encourage women in rural Ghana to get screened for breast cancer. One method offers screening for breast cancer along with diabetes and high blood pressure. The other involves sessions with men to change attitudes and increase support for women. Th…

This study looks at whether proton beam radiation causes less damage to the heart than standard photon radiation in people with left-sided breast cancer. About 60 participants will receive either proton or photon therapy, and their hearts will be checked with MRI scans. The goal …