BREAST CANCER FEMALE

This early-phase study is testing a personalized vaccine for people with HER2-positive breast cancer. The vaccine is made from the patient's own immune cells and is designed to teach the body's immune system to attack the cancer. Researchers are giving the vaccine alongside stand…

This study aims to see if proton beam radiation causes less heart damage than traditional photon radiation for people with left-sided breast cancer. Researchers will randomly assign 60 participants to receive either proton or photon radiation and use heart MRI scans to measure sc…

This study is testing whether trying hormone therapy for three months before breast cancer surgery helps older women and their doctors decide whether to include radiation in their treatment plan. Researchers want to see if experiencing the hormone therapy first makes patients mor…

This large study is testing if adding a drug called abemaciclib to standard hormone therapy is better at preventing breast cancer from returning. It is for women with a high risk of their cancer coming back after initial treatment. The goal is to see if this combination helps pat…

This study is testing a new drug called azenosertib, combined with two existing cancer drugs, for people with advanced triple-negative breast cancer that has spread. The main goals are to find a safe dose and see if the combination makes tumors shrink. About 78 participants will …

This study tested whether adding a newer drug called pyrotinib to standard chemotherapy and trastuzumab helps shrink tumors more effectively before surgery in women with HER2-positive breast cancer. The goal was to see if this combination leads to better outcomes by eliminating a…

This study is testing whether combining two targeted drugs—sacituzumab govitecan and trastuzumab—can help control metastatic HER2-positive breast cancer that has progressed after standard treatments. The trial will enroll about 28 patients who have already received specific prior…

This study is testing how well a combination of two drugs (docetaxel and trastuzumab) works to shrink tumors before surgery in Nigerian women with a specific type of breast cancer called HER2-positive. The main goal is to see if the treatment can completely eliminate the cancer c…

This study compares a new robotic surgery system to traditional open surgery for nipple-sparing mastectomy in women with early-stage breast cancer. It aims to see if the robotic approach is as safe and effective while potentially improving cosmetic results and recovery. The trial…

This study is for postmenopausal women with early-stage, hormone-sensitive breast cancer who have a high risk of the cancer returning. It aims to see if adding a new drug called abemaciclib to standard hormone therapy is better at preventing cancer recurrence than hormone therapy…

This study is observing women with early-stage, low-risk breast cancer who receive a single dose of radiation during their lumpectomy surgery. The goal is to track how well this one-time treatment works over 5 to 10 years, including cancer recurrence rates and side effects. It al…

This study is testing if a special type of mammogram that uses a contrast dye is better at finding new or returning breast cancers in women who have already had the disease. It compares this new method to the standard mammogram to see if it finds more cancers without causing too …

This study is testing a new method to screen for breast cancer using a simple blood test analyzed by a special laser. Researchers are comparing results from this 'liquid biopsy' to standard mammograms in 1,100 women, including those with breast cancer, those without, and those wi…

This study is testing two different vaccines designed to prevent breast cancer from returning in patients with HER2-positive disease. It focuses on people who still had cancer cells remaining after completing their initial chemotherapy and targeted therapy. Researchers will monit…

This study is testing two different approaches to encourage more women in rural Ghana to get screened for breast cancer early. One approach offers breast cancer screening together with checks for diabetes and high blood pressure. The other approach holds sessions with men to chan…

This study is developing and testing a shorter version of mindfulness therapy specifically for older Black women who have survived breast cancer and are experiencing mild to moderate depression. The program involves 8 weekly one-hour online group sessions that combine mindfulness…

This study is testing an online program called SHINE designed to help breast cancer survivors manage sexual concerns that often arise after treatment. About 340 participants will try different combinations of web-based lessons about sexual health, talking to doctors, communicatin…

This study aims to understand why some women reject or disagree with their personalized breast cancer risk estimates. Researchers will survey 750 women aged 39-74 to identify factors that lead to risk rejection and see how this affects their actual mammogram screening behavior ov…

This study aims to understand how breast cancer itself might affect a woman's eggs and her response to fertility-preserving hormone treatments. Researchers will compare egg cells and fluid from 100 women with breast cancer to those from healthy donors to see if the cancer disrupt…

This study is observing 100 women with breast or gynecological cancers to see if their diet in the month before starting chemotherapy is linked to levels of a blood protein called hepcidin. Researchers will then check if hepcidin levels are connected to how well patients can stic…