BREAST CANCER FEMALE

This study tests if a combination of ribociclib (a targeted pill) and hormone therapy works better than standard chemotherapy for women with a common type of early breast cancer (HR+/HER2-). About 1,684 women with intermediate-risk disease are taking part. The goal is to see whic…

This study looks at whether women with aggressive breast cancers (triple-negative or HER2-positive) who have a complete response to chemotherapy can safely avoid sentinel lymph node biopsy. The trial will enroll 350 patients across Europe, all of whom will have breast-conserving …

This study looks at a new material called SC Derm, used in breast reconstruction after mastectomy for breast cancer. It compares how well this material works and its safety against other similar products. About 120 women aged 20 to 69 who are having a mastectomy and immediate imp…

This study compares a robotic surgical system (da Vinci SP) to traditional open surgery for nipple-sparing mastectomy in women with early-stage breast cancer. The trial involves 204 participants and will measure safety, cancer recurrence, and patient satisfaction. The goal is to …

This phase 2 trial tests the safety and effectiveness of combining sacituzumab govitecan (Trodelvy) with trastuzumab (Herceptin) in 28 people with HER2+ metastatic breast cancer that has worsened after treatment with trastuzumab deruxtecan. The goal is to see how many participant…

This Phase 2 trial is testing a combination of two drugs—docetaxel (chemotherapy) and trastuzumab (a targeted therapy)—in 53 Nigerian women with HER2-positive breast cancer. The goal is to see how many women have no cancer left after treatment (called a complete response). The st…

This phase 3 trial tests whether adding the drug abemaciclib to standard hormone therapy can lower the chance of breast cancer returning in postmenopausal women with a high-risk type. About 123 participants will receive either hormone therapy alone or with abemaciclib for up to 2…

This phase 3 trial studies whether adding the drug abemaciclib (Verzenios) to standard hormone therapy helps prevent breast cancer from coming back in 1,260 women with high-risk, HR+/HER2- early breast cancer. Participants have already completed initial treatments like surgery or…

This phase 2 trial is testing whether adding the targeted drug pyrotinib to standard chemotherapy and trastuzumab before surgery can eliminate more cancer in women with HER2-positive early breast cancer. About 53 participants will receive the combination, and the main goal is to …

This study tests whether contrast-enhanced mammography (CEM) finds breast cancer more accurately than standard mammography in women who have already had breast cancer. About 1,647 women ages 30-85 will get both types of mammograms to compare detection rates and false alarms. The …

This large study is testing whether a new laser-based blood test can help screen for breast cancer. Researchers will compare blood samples from women with and without breast cancer to see if the test can accurately spot the disease. If it works, it could offer a less invasive way…

This study tests two different vaccines designed to prevent HER-2 positive breast cancer from coming back in people who have already completed initial treatment. About 119 participants who had surgery after chemotherapy will receive one of the two vaccines, followed by booster sh…

This study aims to develop and test a shortened version of Mindfulness-Based Cognitive Therapy (MBCT) to improve mood in older African American/Black women who have had breast cancer and now have mild to moderate depression. About 23 participants will attend group sessions and re…

This study tests an internet-based program called SHINE to help breast cancer survivors manage sexual concerns after treatment. About 340 women who finished primary cancer treatment at least 12 weeks ago will join. Participants get online education and tools, and the study checks…

This study looks at why some women disagree with their personal breast cancer risk estimate during mammography screening. Researchers will ask 726 women aged 39-74 about their risk number and whether they want more screening information. The goal is to understand this rejection t…

This study follows 100 women with breast or gynecologic cancers to see if their diet before chemotherapy is linked to levels of a protein called hepcidin, and whether hepcidin levels affect how much chemo they can receive. The goal is to understand if eating certain foods might h…

This study looks at how breast cancer itself may affect a woman's ability to have children later. Researchers are comparing egg quality and hormone responses in 100 women with breast cancer versus healthy egg donors. The goal is to understand why cancer can reduce the number and …

This registry follows 94 women aged 50 and older with early-stage, low-risk breast cancer who received a single dose of radiation directly to the tumor site during lumpectomy (IORT). The goal is to monitor cancer recurrence, side effects, and patient satisfaction over time. Becau…

This study tests two simple approaches to encourage women in rural Ghana to get screened for breast cancer. One approach offers breast cancer screening alongside checks for diabetes and high blood pressure. The other involves sessions with men to change attitudes and increase sup…

This study compares two types of radiation therapy for left-sided breast cancer: proton beam therapy and conventional photon therapy. The goal is to see which one causes fewer changes to the heart, measured by MRI scans. About 60 adults with non-metastatic breast cancer will part…

This study looks at whether taking hormone therapy for 3 months before breast cancer surgery helps women aged 65 and older decide if they want radiation after surgery. The goal is to see if the experience of taking the pills changes their preference. The study does not test a new…