BREAST CANCER FEMALE

This Phase III trial is for women aged 65 and older with early-stage, hormone-sensitive breast cancer. Half will take hormone-blocking pills for three months before surgery, while the other half will proceed directly to surgery as usual. The goal is to see if the pre-surgery pill…

This study tests a combination of two drugs—elacestrant and trastuzumab deruxtecan—in people with a specific type of advanced breast cancer (HR-positive, HER2-low or ultralow) that has stopped responding to standard hormone therapy and CDK4/6 inhibitors. The goal is to find the s…

This study tests whether a negative pressure wound dressing (PICO) can reduce the risk of seroma—a common fluid buildup—after mastectomy for breast cancer. About 76 women will be randomly assigned to get either the standard dressing or the PICO device, which they wear for a week.…

This study looks at a new material called SC DERM® Recon, used in breast reconstruction surgery after mastectomy for breast cancer. Researchers want to see if it causes fewer short-term problems than similar materials. About 120 women will take part, and the study will track comp…

This study is testing a precise, high-dose radiation treatment called SABR as an alternative to surgery for women aged 65 and older with early-stage breast cancer. The goal is to control the cancer while avoiding surgery and maintaining quality of life. Participants will receive …

This study is testing whether a special MRI scan before surgery can identify women with early breast cancer who have a very low risk of the cancer coming back. If so, they may be able to skip radiotherapy after surgery, avoiding its side effects. The trial will follow 1,400 women…

This study tests whether high-intensity focused ultrasound (HIFU) can destroy breast tumors without surgery. Fifteen women with small, early-stage breast cancers will receive HIFU before their planned surgery. The main goal is to see if the ultrasound completely kills the tumor c…

This study tests whether following exercise and healthy eating guidelines can improve heart health and reduce metabolic problems in breast cancer survivors. Forty-five postmenopausal women who had breast cancer will be split into three groups: exercise only, exercise plus dietary…

This study tests whether a special PET/MRI scan can accurately detect if breast cancer has spread to lymph nodes in the armpit, potentially replacing the need for surgical removal of those nodes. About 119 women with certain types of breast cancer (luminal A or lobular) will get …

This study is testing a new 3D automated ultrasound system called ATUSA to see how well it can image suspicious breast lesions. Up to 800 women with suspicious findings on standard imaging will get an ATUSA scan before their biopsy. The goal is to collect images and compare them …

This study is testing a new blood test called Oncoliq to see if it can find breast cancer early. Researchers will collect blood from 300 women, some with breast cancer and some without, to check for tiny molecules called miRNAs that tumors release. The goal is to create a simple,…

This study trains Nigerian radiologists to use tablet-based ultrasound to guide breast biopsies, a method that is more accurate than the blind biopsies or surgical excisions currently used. Nine hundred women with suspicious breast lumps will participate. The goal is to make this…

This study is testing whether adding a special type of mammogram (contrast-enhanced mammography, or CEM) every two years to the standard yearly 3D mammogram can find new breast cancers in women who have already had breast cancer. The goal is to see if CEM detects more cancers whi…

This study looks at whether a 12-week aerobic and resistance exercise program can lower breast cancer risk in women with dense breast tissue. Researchers will measure changes in blood markers and breast tissue samples from 46 physically inactive women aged 18-59. Participants are…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain caused by chemotherapy in breast and gynecologic cancer survivors. About 19 women who have persistent pain after chemo will receive…

This pilot study in Singapore tests whether exercise therapy and cognitive behavioral therapy (CBT) can reduce fatigue and improve treatment adherence in female breast cancer patients. 100 women who have completed surgery and chemotherapy will be enrolled. The study focuses on wh…

This study looks at whether a telehealth exercise program with protein support can help women aged 65 and older with breast cancer receive all their planned chemotherapy at the right dose. Participants will either do resistance exercises and take protein or receive health educati…

This large phase 3 trial is testing whether giving lidocaine (a numbing medicine) during and after breast cancer surgery can reduce the chance of long-term pain. About 4,300 women having mastectomy or breast-conserving surgery will receive either lidocaine or a placebo. The main …

This study is testing a special radiation device called the GammaPod to give a single, precise dose of radiation to the area where breast cancer was removed. The goal is to see if this approach can shorten the overall treatment time by a few days and improve patients' quality of …

This study tests a training program that teaches breast cancer survivors with memory and concentration problems (brain fog) strategies to improve daily tasks and quality of life. About 50 women who finished cancer treatment 6 months to 3 years ago will participate. The goal is to…

This study tests whether a guided digital self-hypnosis program can reduce hot flashes in women with breast cancer who are on hormone therapy. Hot flashes are a common side effect that often leads patients to stop treatment, raising the risk of cancer returning. Over three weeks,…

This study tests a 12-week exercise program for Black women who have finished breast cancer treatment. The goal is to see if the program is easy to follow and helps improve well-being. About 75 women will take part, with some starting the program right away and others waiting. Re…

This study compares two standard exercise programs to see which one better helps women increase muscle mass after breast cancer treatment. Thirty women aged 20-89 who have completed treatment (except chemotherapy) will follow either standard resistance training or a special 6-12-…

This study tests whether taking creatine, a common dietary supplement, can help breast cancer survivors regain strength and endurance faster when combined with a 12-week exercise program. Sixty women who recently finished chemotherapy will be randomly assigned to exercise with or…

This study looks at whether eating only during an 8-hour window each day (time-restricted eating) can help women with breast cancer feel better and have fewer side effects during chemotherapy. Some participants will also follow a Mediterranean diet. The goal is to see if these ea…

This study looks at why breast cancer patients often have trouble with memory, focus, and thinking after chemotherapy. Researchers will compare 150 women with breast cancer to healthy women of the same age using cognitive tests, blood samples, and optional brain MRIs. The goal is…

This study takes tumor samples from women with aggressive breast cancers (triple-negative or luminal B) and grows them in mice to create patient-derived xenografts (PDX). The goal is to see how well these mouse models mimic the original tumors and to learn about tumor evolution a…

This study looks at how antibiotics change the bacteria in the gut and breast tissue after mastectomy with implant reconstruction. Researchers will collect samples from 200 women to see if certain bacteria are linked to infections. The goal is to better understand infection risks…

This study collects mammogram images and survey responses from 20,000 adults to train artificial intelligence models. The goal is to improve how breast cancer is detected in different groups of people. Participants will also be able to view their own mammogram images through the …

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can help predict how well breast cancer responds to chemotherapy given before surgery. Researchers will take blood samples from 125 women with stage II or III breast cancer before, during, and after treat…

This study follows 310 women who had surgery for breast cancer to see how access to supportive care (like counseling or nutrition advice) affects their quality of life. Participants fill out several questionnaires about their physical, emotional, and social well-being over time. …

This study looks at how oxygen levels in breast tumors change during surgery and how those changes affect gene activity. Researchers will take small tumor samples at three points during surgery from 500 women with breast cancer. The goal is to understand the body's response to su…