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Groundbreaking trial could spare thousands of breast cancer patients from unnecessary surgery

NCT ID NCT04101851

Ongoing Disease control Sponsor: Toralf Reimer, MD PhD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether women with aggressive breast cancers (triple-negative or HER2-positive) who have a complete response to chemotherapy can safely avoid sentinel lymph node biopsy. The trial will enroll 350 patients across Europe, all of whom will have breast-conserving surgery but no lymph node removal. The goal is to see if this approach maintains excellent cancer control while reducing side effects like lymphedema.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm female breast carcinoma HER2 positive breast carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER BREAST CANCER FEMALE

Contacts and locations

Locations

  • Agaplesion Diakonie Klinikum, Frauenklinik

    Hamburg, Germany

  • Albertinen Krankenhaus, Gynäkologie

    Hamburg, Germany

  • Asklepios Paulinen Klinik, Frauenklinik

    Wiesbaden, Germany

  • Augusta-Klinik Brustzentrum

    Bochum, Germany

  • Brustzentrum Klinikum Siloah

    Hanover, 30459, Germany

  • Brustzentrum Kreisklinik Ebersberg

    Ebersberg, Germany

  • Brustzentrum Nordsachsen, Frauenklinik

    Borna, Germany

  • Carl-Thiem-Klinikum, Frauenklinik

    Cottbus, Germany

  • DRK Kliniken Köpenick, Brustzentrum

    Berlin, Germany

  • Diakonissen-Krankenhaus Brustzentrum

    Dresden, Germany

  • Diakonissen-Stiftungs-Krankenhaus, Gynäkologie

    Speyer, Germany

  • Elisabeth Krankenhaus, Brustzentrum

    Kassel, Germany

  • Evang. Waldkrankenhaus Spandau, Brustzentrum

    Berlin, Germany

  • Helios HSK, Brustzentrum

    Wiesbaden, Germany

  • Helios Klinik, Gynäkologie

    Schkeuditz, Germany

  • Helios Kliniken Schwerin, Frauenklinik

    Schwerin, Germany

  • Johanniter-Krankenhaus, Frauenklinik

    Stendal, Germany

  • Klinikum Esslingen, Frauenklinik

    Esslingen am Neckar, Germany

  • Klinikum Hanau GmbH, Frauenklinik

    Hanau, Germany

  • Klinikum Mittelbaden Brustzentrum

    Baden-Baden, Germany

  • Klinikum Passau, Frauenklinik

    Passau, Germany

  • Kreiskliniken Böblingen, Frauenklinik

    Böblingen, Germany

  • Ludmillenstift, Brustzentrum

    Meppen, Germany

  • Marienhospital, Klinik für Gynäkologie

    Bottrop, Germany

  • Med. Universität Graz, Frauenklinik

    Graz, Austria

  • Medizinische Hochschule Hannover, Frauenklinik

    Hanover, Germany

  • Praxis Dres. Heinrich & Bangerter

    Augsburg, Germany

  • Rems-Murr-Klinik, Frauenklinik

    Winnenden, Germany

  • San Raffaele Hospital, Breast Unit

    Milan, Italy

  • Sana Klinikum Hameln-Pyrmont

    Hamelin, Germany

  • Sana Klinikum Lichtenberg

    Berlin, Germany

  • St. Josefs-Hospital, Frauenklinik

    Wiesbaden, Germany

  • Stadtkrankenhaus Worms gGmbH, Brustzentrum

    Worms, Germany

  • Uni-Klinikum Essen, Frauenklinik

    Essen, Germany

  • Universidad de Navarra

    Madrid, 28027, Spain

  • Universitäts-Frauenklinik am Klinikum Südstadt

    Rostock, Germany

  • Universitäts-Klinikum Magdeburg, Frauenklinik

    Magdeburg, Germany

  • Universitäts-Klinikum, Frauenklinik

    Augsburg, Germany

  • Universitätsklinikum Heidelberg, Frauenklinik

    Heidelberg, Germany

  • ViDia Christliche Kliniken, Frauenklinik

    Karlsruhe, Germany

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