New trial aims to find safer treatment for early HER2 breast cancer

NCT ID NCT04893109

Recruiting now Disease control Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This phase 2 trial is testing two different drug combinations for people with stage I HER2-positive breast cancer after surgery. One group gets trastuzumab emtansine (T-DM1) followed by trastuzumab injections, while the other gets paclitaxel plus trastuzumab. The goal is to see which approach causes fewer serious side effects and better prevents the cancer from coming back. About 500 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: trastuzumab emtansine (T-DM1), trastuzumab SC, and paclitaxel
What this could lead to: If successful, this study could identify a safer and more effective treatment option for early-stage HER2-positive breast cancer, reducing side effects while maintaining disease control.
What could go wrong: This is a phase 2 trial with 500 participants, so results are preliminary. The treatments may cause significant side effects, and the study may not show a clear benefit for one approach over the other.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm HER2 positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER HER2-POSITIVE BREAST CANCER

Contacts and locations

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Locations

Berkshire Medical Center
RECRUITING

Pittsfield, Massachusetts, 01201, United States
Beth Israel Deaconess Medical Center
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02215, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Dana Farber at South Shore Hospital
RECRUITING

Weymouth, Massachusetts, 02190, United States
Dana-Farber Brigham Cancer Center - Foxborough
RECRUITING

Foxborough, Massachusetts, 02035, United States
Dana-Farber Cancer Insitute at Londonderry Hospital
RECRUITING

Londonderry, New Hampshire, 03053, United States
Dana-Farber Cancer Instiute - Merrimack Valley
RECRUITING

Methuen, Massachusetts, 01844, United States
Dana-Farber at Milford
RECRUITING

Milford, Massachusetts, 01757, United States
Dana-Farber at St. Elizabeth's Medical Center
RECRUITING

Brighton, Massachusetts, 02135, United States
Duke University Medical Center
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27710, United States
Duke Women's Cancer Care Raleigh
ACTIVE_NOT_RECRUITING

Raleigh, North Carolina, 27710, United States
Eastern Maine Medical Center (Northern Light)
RECRUITING

Brewer, Maine, 04412, United States
Greco-Hainsworth Centers for Research/Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
IU Health North Hospital
ACTIVE_NOT_RECRUITING

Carmel, Indiana, 46032, United States
Indiana University Health Joe & Shelly Schwarz Cancer Center
ACTIVE_NOT_RECRUITING

Carmel, Indiana, 46032, United States
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46202, United States
Indiana University Sidney and Lois Eskenazi Hospital
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46202, United States
Lahey Clinic
RECRUITING

Burlington, Massachusetts, 01805, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Mass General North Shore Cancer Center
RECRUITING

Danvers, Massachusetts, 01923, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02215, United States
Miami Cancer Institute - Plantation (MCIP)
RECRUITING

Plantation, Florida, 33324, United States
Miami Cancer Institute/Baptist Hospital of Miami
RECRUITING

Miami, Florida, 33176, United States
NH Oncology-Hematology, PA - Payson Center for Cancer Care
RECRUITING

Concord, New Hampshire, 03301, United States
New England Cancer Specialists
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
New England Cancer Specialists - Portsmouth
RECRUITING

Portsmouth, New Hampshire, 03801, United States
New York University Langone Health
RECRUITING

New York, New York, 10016, United States
New York University Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States
New York University Langone Hospital -Brooklyn
RECRUITING

Brooklyn, New York, 11220, United States
Newton Wellesley Hospital
RECRUITING

Newton, Massachusetts, 02462, United States
Northwell University
RECRUITING

New York, New York, 10075, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Smilow Cancer Hospital Care center at Derby
RECRUITING

Derby, Connecticut, 06418, United States
Smilow Cancer Hospital Care center at Fairfield
RECRUITING

Fairfield, Connecticut, 06824, United States
Smilow Cancer Hospital Care center at Glastonbury
RECRUITING

Glastonbury, Connecticut, 06033, United States
Smilow Cancer Hospital Care center at Greenwich
RECRUITING

Greenwich, Connecticut, 06830, United States
Smilow Cancer Hospital Care center at Guilford
RECRUITING

Guilford, Connecticut, 06437, United States
Smilow Cancer Hospital Care center at Long Ridge
RECRUITING

Long Ridge, Connecticut, 06902, United States
Smilow Cancer Hospital Care center at North Haven
RECRUITING

North Haven, Connecticut, 06510, United States
Smilow Cancer Hospital Care center at St. Francis
RECRUITING

Hartford, Connecticut, 06105, United States
Smilow Cancer Hospital Care center at Torrington
RECRUITING

Torrington, Connecticut, 06790, United States
Smilow Cancer Hospital Care center at Trumbull
RECRUITING

Trumbull, Connecticut, 06611, United States
Smilow Cancer Hospital Care center at Waterbury
RECRUITING

Waterbury, Connecticut, 06708, United States
Smilow Cancer Hospital Care center at Waterford
RECRUITING

Waterford, Connecticut, 06385, United States
Smilow Cancer Hospital Care center at Westerly
RECRUITING

Westerly, Rhode Island, 02891, United States
Solinsky Center for Cancer Care (NH Oncology-Hematology, PA)
RECRUITING

Manchester, New Hampshire, 03103, United States
Stamford Hospital
RECRUITING

Stamford, Connecticut, 06904, United States
Stefanie Spielman Comprehensive Breast Center
RECRUITING

Columbus, Ohio, 43212, United States
The University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94158, United States
University of Pennsylvania, Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center Cancer UPMC- Magee Women's Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
Yale Cancer Center at Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06520-8028, United States

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