New study seeks safer, effective treatment for early HER2 breast cancer
NCT ID NCT04893109
First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 25 times
Summary
This study is for people with early-stage (stage I) HER2-positive breast cancer who have had surgery. It compares two treatment plans: one uses the drug T-DM1 followed by trastuzumab, and the other uses paclitaxel plus trastuzumab. The goal is to see which approach causes fewer side effects and helps prevent the cancer from coming back. About 500 participants will be enrolled.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
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Berkshire Medical Center
RECRUITINGPittsfield, Massachusetts, 01201, United States
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
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Dana Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Dana Farber at South Shore Hospital
RECRUITINGWeymouth, Massachusetts, 02190, United States
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Dana-Farber Brigham Cancer Center - Foxborough
RECRUITINGFoxborough, Massachusetts, 02035, United States
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Dana-Farber Cancer Insitute at Londonderry Hospital
RECRUITINGLondonderry, New Hampshire, 03053, United States
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Dana-Farber Cancer Instiute - Merrimack Valley
RECRUITINGMethuen, Massachusetts, 01844, United States
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Dana-Farber at Milford
RECRUITINGMilford, Massachusetts, 01757, United States
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Dana-Farber at St. Elizabeth's Medical Center
RECRUITINGBrighton, Massachusetts, 02135, United States
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Duke University Medical Center
ACTIVE_NOT_RECRUITINGDurham, North Carolina, 27710, United States
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Duke Women's Cancer Care Raleigh
ACTIVE_NOT_RECRUITINGRaleigh, North Carolina, 27710, United States
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Eastern Maine Medical Center (Northern Light)
RECRUITINGBrewer, Maine, 04412, United States
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Greco-Hainsworth Centers for Research/Tennessee Oncology
RECRUITINGNashville, Tennessee, 37203, United States
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IU Health North Hospital
ACTIVE_NOT_RECRUITINGCarmel, Indiana, 46032, United States
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Indiana University Health Joe & Shelly Schwarz Cancer Center
ACTIVE_NOT_RECRUITINGCarmel, Indiana, 46032, United States
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Indiana University Melvin and Bren Simon Comprehensive Cancer Center
ACTIVE_NOT_RECRUITINGIndianapolis, Indiana, 46202, United States
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Indiana University Sidney and Lois Eskenazi Hospital
ACTIVE_NOT_RECRUITINGIndianapolis, Indiana, 46202, United States
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Lahey Clinic
RECRUITINGBurlington, Massachusetts, 01805, United States
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Mass General North Shore Cancer Center
RECRUITINGDanvers, Massachusetts, 01923, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02215, United States
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Miami Cancer Institute - Plantation (MCIP)
RECRUITINGPlantation, Florida, 33324, United States
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Miami Cancer Institute/Baptist Hospital of Miami
RECRUITINGMiami, Florida, 33176, United States
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NH Oncology-Hematology, PA - Payson Center for Cancer Care
RECRUITINGConcord, New Hampshire, 03301, United States
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New England Cancer Specialists
RECRUITINGScarborough, Maine, 04074, United States
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New England Cancer Specialists - Portsmouth
RECRUITINGPortsmouth, New Hampshire, 03801, United States
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New York University Langone Health
RECRUITINGNew York, New York, 10016, United States
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New York University Langone Hospital - Long Island
RECRUITINGMineola, New York, 11501, United States
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New York University Langone Hospital -Brooklyn
RECRUITINGBrooklyn, New York, 11220, United States
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Newton Wellesley Hospital
RECRUITINGNewton, Massachusetts, 02462, United States
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Northwell University
RECRUITINGNew York, New York, 10075, United States
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SCRI Oncology Partners
RECRUITINGNashville, Tennessee, 37203, United States
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Smilow Cancer Hospital Care center at Derby
RECRUITINGDerby, Connecticut, 06418, United States
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Smilow Cancer Hospital Care center at Fairfield
RECRUITINGFairfield, Connecticut, 06824, United States
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Smilow Cancer Hospital Care center at Glastonbury
RECRUITINGGlastonbury, Connecticut, 06033, United States
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Smilow Cancer Hospital Care center at Greenwich
RECRUITINGGreenwich, Connecticut, 06830, United States
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Smilow Cancer Hospital Care center at Guilford
RECRUITINGGuilford, Connecticut, 06437, United States
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Smilow Cancer Hospital Care center at Long Ridge
RECRUITINGLong Ridge, Connecticut, 06902, United States
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Smilow Cancer Hospital Care center at North Haven
RECRUITINGNorth Haven, Connecticut, 06510, United States
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Smilow Cancer Hospital Care center at St. Francis
RECRUITINGHartford, Connecticut, 06105, United States
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Smilow Cancer Hospital Care center at Torrington
RECRUITINGTorrington, Connecticut, 06790, United States
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Smilow Cancer Hospital Care center at Trumbull
RECRUITINGTrumbull, Connecticut, 06611, United States
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Smilow Cancer Hospital Care center at Waterbury
RECRUITINGWaterbury, Connecticut, 06708, United States
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Smilow Cancer Hospital Care center at Waterford
RECRUITINGWaterford, Connecticut, 06385, United States
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Smilow Cancer Hospital Care center at Westerly
RECRUITINGWesterly, Rhode Island, 02891, United States
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Solinsky Center for Cancer Care (NH Oncology-Hematology, PA)
RECRUITINGManchester, New Hampshire, 03103, United States
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Stamford Hospital
RECRUITINGStamford, Connecticut, 06904, United States
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Stefanie Spielman Comprehensive Breast Center
RECRUITINGColumbus, Ohio, 43212, United States
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The University of Chicago Medical Center
RECRUITINGChicago, Illinois, 60637, United States
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UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITINGSan Francisco, California, 94158, United States
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University of Pennsylvania, Abramson Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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University of Pittsburgh Medical Center Cancer UPMC- Magee Women's Hospital
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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Yale Cancer Center at Yale University School of Medicine
RECRUITINGNew Haven, Connecticut, 06520-8028, United States
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Conditions
Explore the condition pages connected to this study.