BREAST CANCER METASTATIC

This early-phase study is for people with metastatic HR+ HER2- breast cancer that has spread to the bone. Researchers want to find the best dose of the drug abemaciclib when given together with radiation and hormone therapy. The goal is to control the disease and manage side effe…

This early-phase study tests a new drug called Sapu003 in 27 adults with advanced solid tumors (like breast, kidney, or liver cancer) that are sensitive to mTOR-targeted therapy. The main goal is to find the safest dose and check for side effects. Participants receive Sapu003 wee…

This early-phase study tests a new drug called SLV-154 in about 70 people whose solid tumors (like head and neck, lung, breast, or ovarian cancer) have spread. The main goal is to find a safe dose and watch for side effects. Participants must have a confirmed diagnosis and be in …

This study tests an experimental pill called INX-315 in 150 people with advanced cancers, including certain breast and ovarian cancers that have stopped responding to standard treatments. The goal is to see if the drug is safe and can shrink or control tumors. The study has three…

This early-stage trial tests a new treatment called ES2B-C001, given alone or with an adjuvant, for people with HER2-positive metastatic breast cancer that has not responded to at least two prior therapies. The main goal is to check safety and find the best dose, while also looki…

This study tests the drug trastuzumab deruxtecan (T-DXd) in 40 adults with metastatic breast cancer that has never shown HER2 protein. The goal is to see if the drug shrinks tumors and which patients respond best. Participants must have advanced cancer that has been treated befor…

This early-phase study tests a new treatment for people with metastatic pancreatic or breast cancer that has stopped responding to standard therapies. The treatment combines two chemotherapy drugs with high-dose vitamins and a stem cell transplant to help the body recover. The ma…

This study tests a new drug called evorpacept combined with standard treatments (trastuzumab and chemotherapy) in people with advanced HER2-positive breast cancer that has worsened after prior therapy. About 120 participants will receive the combination to see if it shrinks tumor…

This study tests whether a new treatment called Bria-IMT, given with an immunotherapy drug, helps people with advanced metastatic breast cancer live longer compared to standard chemotherapy. It is for patients whose cancer has not responded to available treatments. About 404 adul…

This study tests a new antibody drug, OM-RCA-01, in people with advanced cancers that have a specific protein called FGFR1. The goal is to see if the drug is safe and can slow tumor growth. About 58 adults with kidney, lung, prostate, breast, or head & neck cancer will receive th…

This early-stage study tests whether adding the drug avasopasem to standard hormone therapy and a CDK 4/6 inhibitor is safe and can help control metastatic hormone receptor positive breast cancer. About 35 women whose cancer has worsened on current treatments will participate. Th…

This study looks at different ways to test for PIK3CA gene mutations in people with metastatic breast cancer. The goal is to see which testing method works best so doctors can choose the right treatment for each patient. About 100 adults with a specific type of breast cancer (hor…

This study tests a special dye that makes cancer cells glow, helping surgeons quickly tell if a lymph node contains cancer during breast cancer surgery. About 60 adults with breast cancer will have their removed lymph nodes treated with the dye and then imaged. The goal is to see…

This study is testing two new imaging agents that light up breast cancer cells on PET scans. Researchers want to see if these agents can find tumors and their spread more accurately than current methods. About 200 women with breast cancer or suspected breast cancer will receive t…

This study is developing a blood test (liquid biopsy) to detect two key genetic mutations (ESR-1 and gBRCA) in people with a common type of advanced breast cancer. The goal is to make testing easier and faster, helping doctors choose the best treatments. Researchers will also bui…

This study tests a special PET scan that uses a radioactive tracer to find low levels of HER2 protein in metastatic breast cancer. About 40 adults with HER2-low breast cancer will receive the tracer and be scanned. The goal is to see if this scan can better detect tumors and help…

This study is testing a new blood test (called a liquid biopsy) to track breast cancer over time. About 93 women with early or advanced breast cancer will give blood samples at several visits. The goal is to see if counting cancer cells in the blood can give doctors useful inform…

This study collects information from 200 Chinese patients with HER2 negative metastatic breast cancer who received sacituzumab govitecan. Researchers will look at how long the cancer stays controlled, tumor shrinkage, and side effects. The goal is to understand how well the drug …

This study looks at how willing and able women with non-metastatic breast cancer are to make healthier food choices. About 200 women who have finished their main cancer treatment will fill out online surveys and review an educational flyer about diet and cancer. The goal is to un…