New combo therapy aims to outsmart resistant breast cancer

NCT ID NCT07007559

Recruiting now Disease control Sponsor: ALX Oncology Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This phase 2 trial is testing whether adding evorpacept to standard trastuzumab and chemotherapy can shrink tumors in people with metastatic HER2-positive breast cancer who have already tried the drug Enhertu. About 120 participants will receive the combination intravenously. The study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: evorpacept (ALX148) combined with trastuzumab (Herceptin) and chemotherapy (paclitaxel, capecitabine, eribulin, gemcitabine, or vinorelbine)
What this could lead to: If successful, this could offer a new treatment option for people with HER2-positive breast cancer that has spread and stopped responding to current therapies.
What could go wrong: This is a small, early-phase trial (Phase 2) with no control group, so results may not prove the combination works better than existing treatments. Side effects from the drug combination are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm HER2 positive breast carcinoma Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER, METASTATIC

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

ASST Papa Giovanni XXIII
RECRUITING

Bergamo, 24127, Italy
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Azienda Ospedaliero Universitaria delle Marche
RECRUITING

Torrette, AN, 60126, Italy
Azienda Ospedaliero- Universitaria Maggiore della CaritÃ, SCDU Oncologia
RECRUITING

Novara, 28100, Italy
Barts Health NHS Trust - St Bartholomew's Hospital
RECRUITING

London, Greater London, EC1A 7BE, United Kingdom
CHU de Besancon
RECRUITING

Besançon, 25030, France
Centre Eugene Marquis
RECRUITING

Rennes, 35042, France
Centre Hospitalier Universitaire (CHU) de Poitiers
RECRUITING

Poitiers, 86000, France
City of Hope
RECRUITING

Duarte, California, 91010, United States
City of Hope Chicago
RECRUITING

Zion, Illinois, 60099, United States
Curie Oncology - Farrer
RECRUITING

Singapore, 217562, Singapore
Fondazione IRCCS San Gerardo Dei Tintori
RECRUITING

Monza, 20900, Italy
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Gabrail Cancer Center
RECRUITING

Canton, Ohio, 44718, United States
HealthPartners Frauenshuh Cancer Center
RECRUITING

Saint Louis Park, Minnesota, 55426, United States
Hopital Europeen Georges Pompidou (HEGP)
RECRUITING

Paris, 75015, France
Hopital de l'Institut Curie
RECRUITING

Paris, 75005, France
Hospital Beata Maria Ana
RECRUITING

Madrid, 28007, Spain
Hospital Universitari Arnau de Villanova
RECRUITING

Lleida, Catalonia, 25198, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Catalonia, 08035, Spain
Hospital Universitario De Basurto
RECRUITING

Bilbao, Basque Country, 48013, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, Andalusia, 41009, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, Andalusia, 29010, Spain
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08041, Spain
Houston Methodist Cancer Center
RECRUITING

Houston, Texas, 77030, United States
IRCCS Azienda Ospedaliera Metropolitana
RECRUITING

Genova, GE, 16132, Italy
IRCCS Azienda Ospedaliero- Universitaria di Bologna, Policlinico di Sant'Orsola
RECRUITING

Bologna, 40138, Italy
IRCCS- Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Inha University Hospital
RECRUITING

Incheon, 22332, South Korea
Korea University Guro Hospital
RECRUITING

Seoul, 08308, South Korea
Lutheran Hospital - Cancer Centers of Colorado
RECRUITING

Golden, Colorado, 80401, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10022, United States
National Cancer Centre Singapore
RECRUITING

Singapore, 168583, Singapore
Nottingham University Hospital NHS Trust
RECRUITING

Nottingham, NG5 1PB, United Kingdom
Oncology Hematology West, Pc Dba Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68130, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Saint Joseph Hospital - Cancer Centers of Colorado
RECRUITING

Denver, Colorado, 80218, United States
Saint Mary's Regional Hospital - Cancer Centers of Colorado
RECRUITING

Grand Junction, Colorado, 81501, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
St. Vincent Regional Hospital - Cancer Centers of Montana
RECRUITING

Billings, Montana, 59102, United States
Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33136, United States
The George Washington Medical facility Associates
RECRUITING

Washington D.C., District of Columbia, 20037, United States
The University of Arizona Cancer Center - North Campus
RECRUITING

Tucson, Arizona, 85719, United States
The University of Texas M.D. Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UC Irvine Health - Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 928686, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92037, United States
University Health Network, Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
University of Michigan Rogel Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Velindre Cancer Centre, Velindre University NHS Trust
RECRUITING

Cardiff, Wales, CF14 2TL, United Kingdom
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Washington University School of Medicine- Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63108, United States

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