ER+ BREAST CANCER

This early-phase study tests two drugs, palbociclib and avelumab, together for people with a specific type of advanced breast cancer (AR+ triple-negative). The main goals are to find the safest doses and see if the combination can shrink tumors. About 45 participants with advance…

This study tests several new drug combinations containing FWD1802 in people with a common type of advanced breast cancer (ER-positive/HER2-negative) that cannot be removed by surgery or has spread. The study has two parts: first, finding the safest dose (Phase 1), and then checki…

This study is for women with a common type of early-stage breast cancer (ER+/HER2-) who have already had radiation and now need a second lumpectomy. Researchers want to see if giving another round of radiation after surgery is safe and helps prevent the cancer from coming back. A…

This study tests if the drug elacestrant can clear cancer DNA from the blood of people with ER+ breast cancer who are at high risk for the cancer coming back years later. About 50 adults whose blood shows signs of cancer but scans show no spread will take elacestrant for up to 2 …

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to a single spot where breast cancer has worsened can help keep the disease from spreading further. About 46 adults with metastatic breast cancer (ER+ or HER2+) will continue their usual drug therapy …

This study tests a new drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their growth. About …

This study tests whether a special PET scan (FES-PET) can help find the best dose of tamoxifen for people with metastatic breast cancer that has an ESR1 mutation. These mutations can make standard tamoxifen doses less effective. The study will enroll 12 participants and use the s…

This study tests a new drug called JAB-2485 in about 100 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and find the right dose, while also looking for signs that the drug shrinks tumors. The trial is in early …

This study looks at whether giving hormone therapy before surgery helps women with a certain type of breast cancer (invasive lobular carcinoma) have cleaner surgical results. The goal is to see if this approach lowers the chance of cancer cells being found at the edges of removed…

This study tests a decision aid for women aged 70 and older with early-stage, low-risk breast cancer. The tool helps them and their doctors discuss treatment options, aiming to reduce aggressive treatments like mastectomy or radiation when not needed. About 402 participants will …

This study is for 500 adults with breast cancer who are about to start treatment like chemotherapy or immunotherapy before surgery. Researchers will collect tumor tissue, blood, and sometimes MRI scans and stool samples during treatment. The goal is to learn why some cancers shri…