Blood test hunts hidden cancer, drug aims to stop it returning

NCT ID NCT06923527

Recruiting now Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 30, 2026 · Updated 3 times

Summary

This study tests whether the drug elacestrant can clear traces of cancer DNA found in the blood of people with hormone receptor-positive breast cancer who are at risk of late recurrence. About 50 adults whose blood tests positive for tumor DNA but show no visible spread will take elacestrant pills daily for up to a year. Researchers will check if the DNA disappears and if it helps keep cancer from coming back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Elacestrant (a hormone therapy pill taken daily)
What this could lead to: If successful, this could show that using a blood test to detect leftover cancer DNA and treating with elacestrant helps prevent breast cancer from coming back years later.
What could go wrong: This is a small, early-phase trial with no control group, so results may not be conclusive. Elacestrant can cause nausea, vomiting, and other side effects, and it may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ERΑ+ BREAST CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

estrogen-receptor positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ERΑ+ BREAST CANCER

Contacts and locations

Show contact details

Locations

Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Montefiore Einstein Comprehensive Cancer Center
RECRUITING

The Bronx, New York, 10461, United States
Sidney Kimmel Comprehensive Cancer Center at John Hopkins
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States

Contact Email: •••••@•••••
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UPMC Hillman Cancer Center
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Yale University
RECRUITING

New Haven, Connecticut, 06510, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.