New drug combo aims to slow advanced breast cancer

NCT ID NCT04920708

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether adding the experimental drug ipatasertib to standard hormone therapy and targeted drugs can help people with a certain type of advanced breast cancer (ER+/HER2-) live longer without their cancer growing. It includes 57 participants whose cancer did not respond well to initial treatment. The goal is to see if the new combination works better than the standard treatment alone.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm estrogen-receptor positive breast cancer hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Addenbrookes Hospital

    Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom

  • Beatson West of Scotland Cancer Centre

    Glasgow, United Kingdom

  • Imperial College University Hospitals NHS Trust

    London, W2 1NY, United Kingdom

  • Mount Vernon Cancer Centre

    London, Surrey, HA6 2RN, United Kingdom

  • Nottingham City Hospital

    Nottingham, United Kingdom

  • Oxford University Hospitals

    Oxford, OX3 7LE, United Kingdom

  • Royal Cornwall Hospital

    Truro, Cornwall, TR1 3LQ, United Kingdom

  • Royal Free Hospital

    London, NW3 2QC, United Kingdom

  • Royal Marsden NHS Foundation Trust

    London, SW3 6JJ, United Kingdom

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX, United Kingdom

  • University College London Hospital

    London, United Kingdom

  • Velindre Cancer Centre

    Cardiff, Wales, CF14 2TL, United Kingdom

  • Western General Hospital

    Edinburgh, EH4 2XU, United Kingdom