Breast cancer study seeks to match drug to tumor patterns
NCT ID NCT06551220
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This observational study tracks 800 people with metastatic breast cancer to see if differences in HER2 levels across tumors affect how well trastuzumab deruxtecan works. Researchers will compare progression-free and overall survival based on HER2 patterns. The goal is to better understand who benefits most from this targeted therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- trastuzumab deruxtecan (T-DXd)
- What this could lead to
- If successful, this could help doctors predict which patients with metastatic breast cancer will benefit most from trastuzumab deruxtecan based on HER2 patterns.
- What could go wrong
- This is an observational study, not a treatment trial. It will not directly test a new therapy, and results may not change practice immediately.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Affiliated Cancer Hospital of Inner Mongolia Medical University
RECRUITINGHohhot, Inner Mongolia, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cancer Hospital of Shantou University Medical College
RECRUITINGShantou, Guangdong, 515041, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Changde Hospital, Xiangya School of Medicine, Central South University
RECRUITINGChangde, Hunan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dana-Farber Cancer Institute, Harvard Medical School
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Email: •••••@•••••
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Fujian Cancer Hospital, Fujian Medical University
RECRUITINGFuzhou, Fujian, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Guangdong Provincial Hospital of Chinese Medicine
RECRUITINGGuangzhou, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University
RECRUITINGChangsha, Hunan, 410013, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Cancer Center Shenzhen Hospital
RECRUITINGShenzhen, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shenzhen People's Hospital
RECRUITINGShenzhen, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sun Yat-sen University Cancer Center
RECRUITINGGuangzhou, Guangdong, 510060, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The 10th Affiliated Hospital of Southern Medical University
RECRUITINGDongguan, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated Cancer Hospital, Guangzhou Medical University
RECRUITINGGuangzhou, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated Panyu Central Hospital, Guangzhou Medical University
RECRUITINGGuangzhou, Guangdong, 511400, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Fifth Affiliated Hospital of Sun Yat-sen University
RECRUITINGZhuhai, Guangdong, 519000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Guangzhou Medical University
RECRUITINGGuangzhou, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Guangzhou University of Chinese Medicine
RECRUITINGGuangzhou, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Nanjing Medical University
RECRUITINGNanjing, Jiangsu, 210029, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital, Hengyang Medical School, University of South China
RECRUITINGHengyang, Hunan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First People's Hospital of Foshan
RECRUITINGFoshan, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Affiliated Hospital, Zhejiang University School of Medicine
RECRUITINGHangzhou, Zhejiang, China
Contact Email: •••••@•••••
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The Second Xiangya Hospital of Central South University
RECRUITINGChangsha, Hunan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Sixth Affiliated Hospital, School of Medicine, South China University of Technology.
RECRUITINGFoshan, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Xinhua Hospital Afliated to Shanghai Jiaotong University
RECRUITINGShanghai, Shanghai Municipality, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Yale Cancer Center
RECRUITINGNew Haven, Connecticut, 06510, United States
Contact Email: •••••@•••••
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Yuebei People's Hospital of Shantou University
RECRUITINGShaoguan, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zhongshan City People's Hospital
RECRUITINGZhongshan, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- PET scan could reveal which breast cancer patients will respond to targeted therapy
- Could a targeted drug re-sensitize resistant breast cancer?