Cure My Disease

Don't miss your cure!

 Log in / Sign up

New trial aims High-Dose chemo directly at liver tumors in breast cancer patients

NCT ID NCT06875128

Recruiting now Disease control Sponsor: Delcath Systems Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether delivering high-dose chemotherapy directly to the liver (using a special system) followed by standard cancer drugs works better than standard drugs alone for people with breast cancer that has spread mainly to the liver. About 90 participants will be randomly assigned to one of two groups. The study tracks how long the liver tumors stay under control and any side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Melphalan delivered directly to the liver via HDS (hepatic delivery system), followed by eribulin, vinorelbine, or capecitabine
What this could lead to
If it works, this could offer a new way to control breast cancer that has spread to the liver, potentially slowing liver tumor growth and improving outcomes.
What could go wrong
This is an early phase 2 trial with only 90 participants, so results may not apply broadly. The liver-directed procedure carries risks like infection, bleeding, or liver damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METASTATIC BREAST CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

breast carcinoma breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC BREAST CANCER IN THE LIVER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44106, United States

  • Instiuto Europeo de Oncologia

    RECRUITING

    Milan, Italy

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

  • Ohio State University, Stefanie Spielman Comprehensive Breast Center

    RECRUITING

    Columbus, Ohio, 43212, United States

  • UT Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75325, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.