Morning or evening? new study tests best time for cancer pill.

NCT ID NCT07252726

Recruiting now Knowledge-focused Sponsor: Ottawa Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This pilot study is testing whether taking endocrine therapy in the morning or evening makes a difference for people with metastatic breast or prostate cancer. Fifty participants will be randomly assigned to take their medication either within an hour of waking or within an hour of bedtime. The main goal is to see if a larger trial is possible, while also looking at quality of life, side effects, and how well the treatment works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: endocrine therapy (CDK4/6 inhibitor or androgen receptor pathway inhibitor)
What this could lead to: If successful, this could show that simply changing the time of day you take your medication improves quality of life and treatment tolerability.
What could go wrong: This is a small pilot study with only 50 participants, so results may not apply broadly. The main goal is to see if a larger trial is possible, not to prove effectiveness.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm hormone receptor-positive breast cancer metastatic prostate carcinoma Neoplasm Metastasis prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC BREAST CANCER METASTATIC PROSTATE CANCER

Contacts and locations

Locations

Saskatoon Cancer Centre
NOT_YET_RECRUITING

Saskatoon, Saskatchewan, Canada
The Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
Waterloo Regional Health Network
RECRUITING

Kitchener, Ontario, Canada

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