METASTATIC BREAST CANCER

This study tests two powerful targeted drugs, sacituzumab govitecan (SG) and trastuzumab deruxtecan (T-DXd), in people with a specific type of advanced breast cancer (HER2-low/TROP2-high). The goal is to see which drug works better when given first, and what happens when patients…

This early-stage study looks at whether eating food changes how the body absorbs an oral chemotherapy drug (paclitaxel) when taken with another drug (encequidar). About 46 adults with advanced solid tumors, like metastatic breast cancer, will take the drugs either after fasting o…

This study tests a new drug combination (RC48 plus chemotherapy) against standard treatment (trastuzumab or inetetamab plus chemo) in people with HER2-positive advanced breast cancer whose disease worsened or who couldn't tolerate a prior type of antibody-drug conjugate. About 26…

This study tests a device called TheraBionic P1 in 82 people with advanced or metastatic HR-positive, HER2-negative breast cancer who have already tried standard hormone therapies. The goal is to see if the device can slow cancer growth and improve survival. Participants will use…

This study looks at whether adding precise radiation (SABR) to the current hormone therapy and CDK4/6 inhibitor can delay the need to change cancer drugs in people with ER-positive, HER2-negative advanced breast cancer that has started to grow in a few spots. About 74 participant…

This study tests a new combination of two drugs (JSKN016 and D-0502) in people with a common type of advanced breast cancer (HR-positive, HER2-negative) that has worsened after standard hormone therapy. About 60 adults will receive the drugs either every 2 or 3 weeks. The goal is…

This study tests a virtual group lifestyle program for women with metastatic breast cancer. The goal is to see if different levels of support help participants stick with healthy habits like diet and exercise. About 100 women with stable HR+/HER2- breast cancer will take part. Th…

This study tests an educational program called SHARE-MC designed to help women with metastatic breast cancer address sexual health concerns. Researchers will enroll 96 women and measure changes in sexual function and emotional distress. The goal is to see if this program can impr…

This early study tests if a new device that uses short electric pulses is safe for treating cancer spots just under the skin in people with metastatic breast cancer. About 20 adults will receive the treatment, and researchers will watch for side effects and check quality of life.…

This study looks at whether an artificial intelligence (AI) tool can safely and accurately help breast cancer patients learn about their condition and treatment. About 35 adults with breast cancer will use the AI tool to ask questions and get answers. Doctors will check if the in…

This study looks at whether a special type of PET-CT scan can detect if a drug called trastuzumab deruxtecan is working earlier than standard CT scans in people with HER2 low breast cancer that has spread. About 262 participants will be followed to see if the scan helps doctors s…

This study looks at whether training oncologists in shared decision-making and giving patients educational booklets and videos can improve how treatment choices are made for HER2-negative metastatic breast cancer. About 120 patients starting their first treatment will join, and t…

This study tracks 600 adults in Korea with HER2-positive advanced or metastatic breast cancer who are starting TUKYSA for the first time. Researchers will collect safety and effectiveness data from routine medical care to confirm the drug's real-world performance. The goal is to …