Zapping resistant tumors: could radiation extend the life of current breast cancer therapy?
NCT ID NCT06882499
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial is for people with ER-positive, HER2-negative advanced breast cancer whose disease has started to grow in a few spots while on hormone therapy and a CDK4/6 inhibitor. It tests whether adding targeted radiation (SABR) to those spots allows patients to stay on their current treatment longer, compared to switching to a different systemic therapy chosen by their doctor. The study aims to see if this strategy delays the need for a treatment change.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Stereotactic ablative radiotherapy (SABR)
- What this could lead to
- If successful, this approach could allow patients to stay on their current hormone therapy longer by zapping resistant spots with radiation, delaying the need for stronger drugs.
- What could go wrong
- This is a small, early-stage trial (74 participants) and may not show a clear benefit. SABR can cause side effects like fatigue or local pain, and not all patients may be suitable for radiation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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