Can a Two-Drug punch wake up 'Cold' tumors?
NCT ID NCT05000294
First seen Jun 26, 2026 · Last updated Jul 14, 2026 · Updated 3 times
Summary
This study tests whether adding tivozanib (a drug that targets blood vessel growth) to atezolizumab (an immunotherapy) can help the immune system attack cancers that normally resist immunotherapy. The trial includes people with several cancer types like bile duct, pancreatic, prostate, and ovarian cancer. Researchers will check if the combination shrinks tumors and how long it keeps them from growing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Atezolizumab (Tecentriq) and tivozanib (Fotivda)
- What this could lead to
- If it works, this could offer a new treatment option for several hard-to-treat cancers that don't respond to immunotherapy alone.
- What could go wrong
- This is an early-phase trial with only 29 participants, so results may not apply broadly. The combination may cause side effects like high blood pressure or immune-related reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Florida
RECRUITINGGainesville, Florida, 32608, United States
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