New hope for hard-to-treat breast cancer: targeted combo enters phase 3

NCT ID NCT06982521

Recruiting now Disease control Sponsor: Relay Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 11, 2026 · Updated 24 times

Summary

This study tests whether a new drug (RLY-2608) combined with fulvestrant works better than another approved combination (capivasertib + fulvestrant) for people with advanced or metastatic HR+/HER2- breast cancer that has a PIK3CA mutation. About 540 adults whose cancer worsened after prior CDK4/6 inhibitor treatment will take part. The main goal is to see how long the cancer stays under control.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AOU Ferrara, Arcispedale Sant'Anna
RECRUITING

Cona, 44124, Italy
Aalborg University Hospital
RECRUITING

Aalborg, 9000, Denmark
AdventHealth
RECRUITING

Altamonte Springs, Florida, 32701, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Associação Hospitalar Moinhos de Vento
RECRUITING

Porto Alegre, 90560-032, Brazil
Avera Cancer Institute
RECRUITING

Sioux Falls, South Dakota, 57105, United States
Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
RECRUITING

Palermo, 90127, Italy
Azienda Ospedaliero Universitaria delle Marche
RECRUITING

Ancona, 60126, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
RECRUITING

Brescia, 25123, Italy
Azienda USl Toscana Nord Ovest SC Oncologia Medica Ospedale Civile Livorno
RECRUITING

Livorno, 57124, Italy
Ballarat Oncology & Haematology Clinical Research Fund
RECRUITING

Wendouree, Victoria, 3355, Australia
Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85234, United States
Barwon Health
RECRUITING

Geelong, Victoria, 3220, Australia
Baylor Scott and White Medical Center
RECRUITING

Temple, Texas, 76508, United States
Bayside Health (Alfred)
RECRUITING

Melbourne, Victoria, 3004, Australia
Beverly Hills Cancer Center
RECRUITING

Beverly Hills, California, 90211, United States
CHA Bundang Medical Center, CHA University
RECRUITING

Seongnam-si, 13496, South Korea
CHR de Verviers site Tourelle
RECRUITING

Verviers, 4800, Belgium
CHU Besancon
RECRUITING

Besançon, 25030, France
CHU-UCL Namur, Site Sainte-Elisabeth
RECRUITING

Namur, 5000, Belgium
Cancer Care Centers of Brevard, Inc
RECRUITING

Palm Bay, Florida, 32909, United States
Cancer Center of Kansas
RECRUITING

Wichita, Kansas, 67214, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Centre François Baclesse
RECRUITING

Caen, 14000, France
Centre Hospitalier de l'Ardenne
RECRUITING

Libramont, 6800, Belgium
Centre Leon Berard
RECRUITING

Lyon, 69008, France
Centre de Cancérologie du Grand Montpellier
RECRUITING

Montpellier, 34070, France
Centro Gaúcho Integrado - Hospital Mae de Deus
RECRUITING

Porto Alegre, 90110-270, Brazil
Centro Medico Dr. Doreski- Fundacion Respirar
RECRUITING

Buenos Aires, 1426, Argentina
Centro de Oncologia do ABC- CEON+ Unidade Sao Caetano do Sul
RECRUITING

São Caetano do Sul, São Paulo, 09541-270, Brazil
Chang Gung Memorial Hospital, Linkou
RECRUITING

Taoyuan, 333, Taiwan
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States
Clinica Universidad de Navarra
RECRUITING

Madrid, 28027, Spain
Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States
Community Health Network, Inc
RECRUITING

Indianapolis, Indiana, 46250, United States
Curie Oncology (Farrer)
RECRUITING

Singapore, 217562, Singapore
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Florida Cancer Specialists-South
RECRUITING

Fort Myers, Florida, 33901, United States
Gangnam Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 06273, South Korea
General University Hospital of Crete
RECRUITING

Heraklion, 715 00, Greece
Georgetown University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Haga Ziekenhuis
RECRUITING

The Hague, 2545, Netherlands
Hong Kong United Oncology Centre
RECRUITING

Hong Kong, HGK, Hong Kong
Hopital du Leman
RECRUITING

Thonon-les-Bains, 74200, France
Hospital Beata Maria Ana/IOB Madrid
RECRUITING

Madrid, 28007, Spain
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital General Universitario Morales Meseguer
RECRUITING

Murcia, 30008, Spain
Hospital San Giuseppe
RECRUITING

Milan, 50053, Italy
Hospital San Pedro de Alcantara
RECRUITING

Cáceres, 10003, Spain
Hospital Universitari Arnau de Vilanova
RECRUITING

Lleida, 25198, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Juan Ramon Jimenez
RECRUITING

Huelva, 21005, Spain
Hospital Universitario Virgen de la Arrixaca
RECRUITING

El Palmar, 30120, Spain
Hospital Universitario de Badajoz
RECRUITING

Badajoz, 06006, Spain
Hospital Universitario de Canarias
RECRUITING

San Cristóbal de La Laguna, 38320, Spain
Hospital da Luz
RECRUITING

Lisbon, 1500-650, Portugal
Houston Methodist Hospital Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Hôpital Privé Jean Mermoz
RECRUITING

Lyon, 69008, France
ICO Girona - Hospital Universitari de Girona Dr Josep Trueta
RECRUITING

Girona, 17007, Spain
IRCCS Candiolo
RECRUITING

Candiolo, 10060, Italy
IRCCS Istituto Romagnolo per lo Studio Dei Tumori (IRST) "Dino Amadori"
RECRUITING

Meldola, 47014, Italy
IRCCS Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Iaso Hospital
RECRUITING

Athens, 151 21, Greece
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Institut Claudius Regaud
RECRUITING

Toulouse, 31300, France
Institut Jules Bordet
RECRUITING

Brussels, 1070, Belgium
Instituto Valenciano de Oncologia (IVO)
RECRUITING

Valencia, 46009, Spain
Instituto de Educação Pesquisa e Gestão em Saúde
RECRUITING

Rio de Janeiro, 22775-001, Brazil
Instituto do Câncer do Ceará
RECRUITING

Fortaleza, 60430-235, Brazil
Interbalkan Hospital of Thessaloniki
RECRUITING

Thessaloniki, 570 01, Greece
Irmandade da Santa Casa de Misericórdia de Porto Alegre
RECRUITING

Porto Alegre, 90020-090, Brazil
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
John Theurer Cancer Center at Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Kaiser Permanente Medical Center
RECRUITING

Vallejo, California, 94589, United States
Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 833, Taiwan
Korea University Guro Hospital
RECRUITING

Seoul, 08308, South Korea
L'Institut de Cancérologie de l'Ouest (ICO) - Angers
RECRUITING

Angers, 49055, France
LKH Feldkirch, Interne E am LKH Rankweil
RECRUITING

Rankweil, 6830, Austria
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health
RECRUITING

New York, New York, 10016, United States
MHAT "Dr. Tota Venkova", AD
RECRUITING

Gabrovo, 5300, Bulgaria
Maastricht University Medical Center
RECRUITING

Maastricht, 6229, Netherlands
Marienhospital Bottrop gGmbH
RECRUITING

Bottrop, 46236, Germany
Masarykuv onkologicky ustav
RECRUITING

Brno, 656 53, Czechia
Mater Hospital Sydney
RECRUITING

North Sydney, 2060, Australia
Medical Oncology Hematology Consultants, P.A.
RECRUITING

Newark, Delaware, 19713, United States
Medical University of Graz
RECRUITING

Graz, 8036, Austria
Memorial Sloan-Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Minnesota Oncology Hematology, P.A.
RECRUITING

Minneapolis, Minnesota, 55404, United States
Mruk-Med Sp. z o.o
RECRUITING

Rzeszów, 35-234, Poland
National Taiwan University Hospital
RECRUITING

Taipei, 100225, Taiwan
Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68130, United States
Nucleo de Oncologia da Bahia S.A.
RECRUITING

Salvador, 40170-110, Brazil
Oncoclinicas Natal- Centro de Pesquisa Oncology Natal
RECRUITING

Natal, 59020-505, Brazil
Oncoclinicas Rio de Janeiro S.A.
RECRUITING

Rio de Janeiro, 22250-905, Brazil
Oncolinicas do Brasil Serviços Médicos S.A (Oncocentro)
RECRUITING

Belo Horizonte, 30360-680, Brazil
Ordensklinikum Linz GmbH
RECRUITING

Linz, 4010, Austria
Oregon Health & Science University, Knight Cancer Institute
RECRUITING

Portland, Oregon, 97210, United States
Peter MacCallum Cancer Center
RECRUITING

Melbourne, Victoria, 3000, Australia
Pratia MCM Krakow
RECRUITING

Krakow, 30-727, Poland
Praxis fuer Interdisziplinaere Onkologie und Haematologie
RECRUITING

Freiburg im Breisgau, 79110, Germany
Profound Research LLC
RECRUITING

Royal Oak, Michigan, 48073, United States
Queen Mary Hospital
RECRUITING

Hong Kong, HGK, Hong Kong
Radboud UMC
RECRUITING

Nijmegen, 6525, Netherlands
Raffles Hospital
RECRUITING

Singapore, 188770, Singapore
Renown Health Medical Oncology
RECRUITING

Reno, Nevada, 89502, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Longmont, Colorado, 80504, United States
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60607, United States
Rutgers Cancer Institute
RECRUITING

New Brunswick, New Jersey, 08901, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Seoul National University Bundang Hospital
RECRUITING

Seoul, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Shuang Ho Hospital, Ministry of Health and Welfare
RECRUITING

New Taipei City, 23561, Taiwan
Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins
RECRUITING

Baltimore, Maryland, 21287, United States
St. Vincent's Hospital Sydney
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Stanford Women's Cancer Center
RECRUITING

Palo Alto, California, 94304, United States
Studienzentrale für das MVZ Eggenfelden GbR
RECRUITING

Eggenfelden, 84307, Germany
Sunnybrook Research Institute
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Sunshine Hospital
RECRUITING

Saint Albans, Victoria, 3021, Australia
Sydney Adventist Hospital
RECRUITING

Wahroonga, New South Wales, 2076, Australia
Sønderborg Sygehus
RECRUITING

Sønderborg, 6400, Denmark
Taichung Veterans General Hospital
RECRUITING

Taichung, 407219, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Tennessee Cancer Specialists
RECRUITING

Knoxville, Tennessee, 37909, United States
Tennessee Oncology, PLLC
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Oncology Central/South
RECRUITING

Austin, Texas, 78731, United States
Texas Oncology DFW
RECRUITING

Dallas, Texas, 75246, United States
The Catholic University of Korea, Seoul St. Mary's Hospital
RECRUITING

Seoul, 06591, South Korea
The Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, Ontario, K1H8L6, Canada
The University of Texas M.D. Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
Uniao Brasileira de Educacao e Assistencia/ Hospital Sao Lucas da PUCRS
RECRUITING

Porto Alegre, 90610-000, Brazil
Unidade Local de Saude de Loures Odivelas E.P.E. Hospital Beatriz Angelo
RECRUITING

Loures, 2674-514, Portugal
Universitaetsmedizin Mannheim
RECRUITING

Mannheim, 68167, Germany
Universitair Ziekenhuis Leuven
RECRUITING

Leuven, 3000, Belgium
University General Hospital of Athens "Attikon"
RECRUITING

Athens, 124 62, Greece
University Hospital Hradec Kralove
RECRUITING

Hradec Králové, 500 05, Czechia
University Hospital of Larissa
RECRUITING

Larissa, 41110, Greece
University of California San Diego Moores Cancer Center
RECRUITING

San Diego, California, 92037, United States
University of California San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94158, United States
University of California, Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Kansas Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39213, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Wisconsin Carbone Cancer Center- University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States
Virginia Cancer Specialists, PC
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Vitaz
RECRUITING

Sint-Niklaas, 9100, Belgium
Washington University School of Medicine- Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63108, United States
William Osler Health System- Brampton Civic Hospital
RECRUITING

Brampton, Ontario, L6R 3J7, Canada
Yale-New Haven Hospital-Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06510, United States
Zealand University Hospital
RECRUITING

Næstved, 4700, Denmark
Zuyderland Medisch Centrum - Heerlen
RECRUITING

Sittard, 6419, Netherlands

Conditions

Explore the condition pages connected to this study.

ADVANCED BREAST CANCER BREAST CANCER HER2-NEGATIVE BREAST CANCER HORMONE RECEPTOR POSITIVE TUMOR METASTATIC BREAST CANCER PIK3CA MUTATION