New pill shows promise in early trial for Hard-to-Treat cancers

NCT ID NCT07318805

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This early-stage study is testing a new oral drug, PF-08032562, in people with advanced breast or colorectal cancer that has spread. The drug is given alone or with other cancer treatments. The main goals are to check safety, find the right dose, and see if it shrinks tumors. About 260 participants are being enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-08032562 (a pill taken by mouth)
What this could lead to: If successful, this could lead to a new treatment option for advanced breast and colorectal cancers that have not responded to standard therapies.
What could go wrong: This is an early Phase 1 trial, so safety and dosing are still being determined. The drug may not work or could cause side effects. It is not yet proven to be effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm colonic neoplasm colorectal adenocarcinoma colorectal cancer colorectal neoplasm hormone receptor-positive breast cancer triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED BREAST CANCER COLORECTAL CANCER METASTATIC BREAST CANCER (HR+/ HER2-) METASTATIC COLORECTAL ADENOCARCINOMA TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

Locations

City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
RECRUITING

Duarte, California, 91010, United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).
RECRUITING

New York, New York, 10021, United States
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy
RECRUITING

Long Island City, New York, 11101, United States
Memorial Sloan Kettering Cancer Center - Main Campus
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center 53rd street.
RECRUITING

New York, New York, 10022, United States
START Midwest, LLC
RECRUITING

Grand Rapids, Michigan, 49546, United States
START Mountain Region
RECRUITING

West Valley City, Utah, 84119, United States
START San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
The University of Texas - M.D. Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
The University of Texas MD Anderson Cancer Center - Conroe
RECRUITING

Conroe, Texas, 77384, United States
The University of Texas, MD Anderson Cancer Center - League City
RECRUITING

League City, Texas, 77573, United States
The University of Texas, MD Anderson Cancer Center - Sugar Land
RECRUITING

Sugar Land, Texas, 77478, United States
The University of Texas, MD Anderson Cancer Center - West Houston
RECRUITING

Houston, Texas, 77079, United States

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