Can a second ADC tame breast cancer after the first fails?
NCT ID NCT06649331
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving a different antibody-drug conjugate (ADC) to people with advanced breast cancer who have already tried an ADC can still shrink tumors or slow the disease. About 160 participants will receive one of several ADCs or a targeted pill. The goal is to see if rechallenging with a new ADC is safe and effective enough to control the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- antibody-drug conjugates (SHR-A1811, SHR-A1921, SHR-A2009, SHR-A2102) and famitinib
- What this could lead to
- If successful, this could show that switching to a different ADC after one stops working is a viable strategy to control metastatic breast cancer.
- What could go wrong
- This is a small, early-phase trial with no control group, so results may not confirm effectiveness. ADCs can cause serious side effects like low blood counts or nerve damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Breast cancer institute of Fudan University Cancer Hospital
RECRUITINGShanghai, Shanghai Municipality, 200032, China
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