Could a lower starting dose help older breast cancer patients stick with treatment?
NCT ID NCT06377852
First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 27 times
Summary
This study looks at whether starting with a lower dose of CDK4/6 inhibitor pills (palbociclib or ribociclib) and slowly increasing the dose helps older adults (65+) with metastatic breast cancer tolerate side effects better and stay on treatment longer. About 500 participants will be randomly assigned to either the standard dose or a lower starting dose that can be increased if well-tolerated. The goal is to find a dosing strategy that keeps patients on effective therapy without overwhelming side effects.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Baptist Memorial Healthcare
RECRUITINGMemphis, Tennessee, 38120, United States
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Dana-Farber Brigham Cancer Center Foxborough
RECRUITINGFoxborough, Massachusetts, 02035, United States
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Dana-Farber Brigham Cancer Center at Milford Regional Medical Center
RECRUITINGMilford, Massachusetts, 01757, United States
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Dana-Farber Brigham Cancer Center at South Shore Health
RECRUITINGWeymouth, Massachusetts, 02190, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Dana-Farber Cancer Institute Merrimack Valley
RECRUITINGMethuen, Massachusetts, 01844, United States
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Dana-Farber/New Hampshire Oncology-Hematology
RECRUITINGLondonderry, New Hampshire, 03053, United States
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Emory University Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
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Ironwood Cancer & Research Centers
RECRUITINGChandler, Arizona, 85224, United States
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Ironwood Cancer & Research Centers
RECRUITINGGilbert, Arizona, 85297, United States
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Ironwood Cancer & Research Centers
RECRUITINGGlendale, Arizona, 85306, United States
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Ironwood Cancer & Research Centers
RECRUITINGGoodyear, Arizona, 85395, United States
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Ironwood Cancer & Research Centers
RECRUITINGMesa, Arizona, 85202, United States
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Ironwood Cancer & Research Centers
RECRUITINGMesa, Arizona, 85206, United States
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Ironwood Cancer & Research Centers
RECRUITINGPhoenix, Arizona, 85028, United States
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Ironwood Cancer & Research Centers
RECRUITINGScottsdale, Arizona, 85260, United States
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Levine Cancer Institute
RECRUITINGAlbemarle, North Carolina, 28001, United States
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Levine Cancer Institute
RECRUITINGCharlotte, North Carolina, 28204, United States
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Levine Cancer Institute
RECRUITINGCharlotte, North Carolina, 28210, United States
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Levine Cancer Institute
RECRUITINGCharlotte, North Carolina, 28211, United States
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Levine Cancer Institute
RECRUITINGCharlotte, North Carolina, 28262, United States
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Levine Cancer Institute
RECRUITINGCharlotte, North Carolina, 28277, United States
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Levine Cancer Institute
RECRUITINGConcord, North Carolina, 28025, United States
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Levine Cancer Institute
RECRUITINGForest City, North Carolina, 28043, United States
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Levine Cancer Institute
RECRUITINGGastonia, North Carolina, 28054, United States
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Levine Cancer Institute
RECRUITINGHuntersville, North Carolina, 28078, United States
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Levine Cancer Institute
RECRUITINGLincolnton, North Carolina, 28092, United States
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Levine Cancer Institute
RECRUITINGMatthews, North Carolina, 28104, United States
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Levine Cancer Institute
RECRUITINGMonroe, North Carolina, 28112, United States
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Levine Cancer Institute
RECRUITINGShelby, North Carolina, 28150, United States
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Levine Cancer Institute
RECRUITINGRock Hill, South Carolina, 29732, United States
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Lewis Cancer and Research Pavilion
RECRUITINGSavannah, Georgia, 31405, United States
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Lovelace Medical Center - Saint Joseph Square
RECRUITINGAlbuquerque, New Mexico, 87102, United States
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Lovelace Women's Hospital
RECRUITINGAlbuquerque, New Mexico, 87109, United States
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Memorial Medical Center
RECRUITINGLas Cruces, New Mexico, 88011, United States
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Miami Cancer Institute
RECRUITINGMiami, Florida, 33176, United States
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Miami Cancer Institute
RECRUITINGPlantation, Florida, 33324, United States
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Penn Medicine - Chester County Hospital
RECRUITINGWest Chester, Pennsylvania, 19380, United States
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Penn Medicine - Lancaster General Hospital
RECRUITINGLancaster, Pennsylvania, 17601, United States
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Penn Medicine - Pennsylvania Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19106, United States
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Penn Medicine - Perelman Center for Advanced Medicine
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Penn Medicine - Princeton Health
RECRUITINGPlainsboro, New Jersey, 08536, United States
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Presbyterian Kaseman Hospital
RECRUITINGAlbuquerque, New Mexico, 87110, United States
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Presbyterian Rust Medical Center/Jorgensen Cancer Center
RECRUITINGRio Rancho, New Mexico, 87124, United States
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SC Cancer Specialists - Hilton Head at St. Joseph's/Candler
RECRUITINGHilton Head Island, South Carolina, 29926, United States
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Smilow Cancer Hospital - Waterford
RECRUITINGWaterford, Connecticut, 06385, United States
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Smilow Cancer Hospital - Westerly
RECRUITINGWesterly, Rhode Island, 02891, United States
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Smilow Cancer Hospital - Yale New Haven Health
RECRUITINGNew Haven, Connecticut, 06510, United States
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Smilow Cancer Hospital Care Center - Derby
RECRUITINGDerby, Connecticut, 06418, United States
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Smilow Cancer Hospital Care Center - Fairfield
RECRUITINGFairfield, Connecticut, 06824, United States
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Smilow Cancer Hospital Care Center - Greenwich
RECRUITINGGreenwich, Connecticut, 06830, United States
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Smilow Cancer Hospital Care Center - Guilford
RECRUITINGGuilford, Connecticut, 06437, United States
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Smilow Cancer Hospital Care Center - North Haven
RECRUITINGNorth Haven, Connecticut, 06473, United States
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Smilow Cancer Hospital Care Center - Torrington
RECRUITINGTorrington, Connecticut, 06790, United States
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Smilow Cancer Hospital Care Center - Trumbull
RECRUITINGTrumbull, Connecticut, 06611, United States
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Smilow Cancer Hospital Care Center - Waterbury
RECRUITINGWaterbury, Connecticut, 06708, United States
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Smilow Cancer Hospital at Glastonbury
RECRUITINGGlastonbury, Connecticut, 06033, United States
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Smilow Cancer Hospital at Saint Francis
RECRUITINGHartford, Connecticut, 06105, United States
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St. Joseph's Candler Bluffton Campus
RECRUITINGBluffton, South Carolina, 29910, United States
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The Jackson Laboratory (JAX) - Harold Alfond Center for Cancer Care
RECRUITINGAugusta, Maine, 04330, United States
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The Jackson Laboratory (JAX) - Northern Light Cancer Care
RECRUITINGBrewer, Maine, 04412, United States
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The University of Kansas Cancer Center
RECRUITINGWestwood, Kansas, 66205, United States
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The University of New Mexico Comprehensive Cancer Center
RECRUITINGAlbuquerque, New Mexico, 87131, United States
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UCHealth Cherry Creek Medical Center
RECRUITINGDenver, Colorado, 80206, United States
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UCHealth Highlands Ranch Hospital
RECRUITINGHighlands Ranch, Colorado, 80129, United States
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University of Colorado Anschutz Medical Campus
RECRUITINGAurora, Colorado, 80045, United States
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Yale University/Yale Cancer Center/Yale School of Medicine
RECRUITINGNew Haven, Connecticut, 06510, United States
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