Could a lower starting dose help older breast cancer patients stick with treatment?

NCT ID NCT06377852

Recruiting now Knowledge-focused Sponsor: American Society of Clinical Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study looks at whether starting with a lower dose of CDK4/6 inhibitor pills (palbociclib or ribociclib) and gradually increasing the dose helps older adults (age 65+) with metastatic breast cancer tolerate side effects better and stay on treatment longer. About 500 participants will be randomly assigned to either the standard approved dose or a lower starting dose that can be increased if well-tolerated. The goal is to find a dosing strategy that reduces treatment discontinuation while maintaining effectiveness.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC BREAST CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

Baptist Memorial Healthcare
RECRUITING

Memphis, Tennessee, 38120, United States
Dana-Farber Brigham Cancer Center Foxborough
RECRUITING

Foxborough, Massachusetts, 02035, United States
Dana-Farber Brigham Cancer Center at Milford Regional Medical Center
RECRUITING

Milford, Massachusetts, 01757, United States
Dana-Farber Brigham Cancer Center at South Shore Health
RECRUITING

Weymouth, Massachusetts, 02190, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Dana-Farber Cancer Institute Merrimack Valley
RECRUITING

Methuen, Massachusetts, 01844, United States
Dana-Farber/New Hampshire Oncology-Hematology
RECRUITING

Londonderry, New Hampshire, 03053, United States
Emory University Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Ironwood Cancer & Research Centers
RECRUITING

Chandler, Arizona, 85224, United States
Ironwood Cancer & Research Centers
RECRUITING

Gilbert, Arizona, 85297, United States
Ironwood Cancer & Research Centers
RECRUITING

Glendale, Arizona, 85306, United States
Ironwood Cancer & Research Centers
RECRUITING

Goodyear, Arizona, 85395, United States
Ironwood Cancer & Research Centers
RECRUITING

Mesa, Arizona, 85202, United States
Ironwood Cancer & Research Centers
RECRUITING

Mesa, Arizona, 85206, United States
Ironwood Cancer & Research Centers
RECRUITING

Phoenix, Arizona, 85028, United States
Ironwood Cancer & Research Centers
RECRUITING

Scottsdale, Arizona, 85260, United States
Levine Cancer Institute
RECRUITING

Albemarle, North Carolina, 28001, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28210, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28211, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28262, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28277, United States
Levine Cancer Institute
RECRUITING

Concord, North Carolina, 28025, United States
Levine Cancer Institute
RECRUITING

Forest City, North Carolina, 28043, United States
Levine Cancer Institute
RECRUITING

Gastonia, North Carolina, 28054, United States
Levine Cancer Institute
RECRUITING

Huntersville, North Carolina, 28078, United States
Levine Cancer Institute
RECRUITING

Lincolnton, North Carolina, 28092, United States
Levine Cancer Institute
RECRUITING

Matthews, North Carolina, 28104, United States
Levine Cancer Institute
RECRUITING

Monroe, North Carolina, 28112, United States
Levine Cancer Institute
RECRUITING

Shelby, North Carolina, 28150, United States
Levine Cancer Institute
RECRUITING

Rock Hill, South Carolina, 29732, United States
Lewis Cancer and Research Pavilion
RECRUITING

Savannah, Georgia, 31405, United States
Lovelace Medical Center - Saint Joseph Square
RECRUITING

Albuquerque, New Mexico, 87102, United States
Lovelace Women's Hospital
RECRUITING

Albuquerque, New Mexico, 87109, United States
Memorial Medical Center
RECRUITING

Las Cruces, New Mexico, 88011, United States
Miami Cancer Institute
RECRUITING

Miami, Florida, 33176, United States
Miami Cancer Institute
RECRUITING

Plantation, Florida, 33324, United States
Northwest Medical Specialties
RECRUITING

Bonney Lake, Washington, 98391, United States
Northwest Medical Specialties
RECRUITING

Federal Way, Washington, 98003, United States
Northwest Medical Specialties
RECRUITING

Gig Harbor, Washington, 98332, United States
Northwest Medical Specialties
RECRUITING

Olympia, Washington, 98502, United States
Northwest Medical Specialties
RECRUITING

Puyallup, Washington, 98373, United States
Northwest Medical Specialties
RECRUITING

Tacoma, Washington, 98405, United States
Penn Medicine - Chester County Hospital
RECRUITING

West Chester, Pennsylvania, 19380, United States
Penn Medicine - Lancaster General Hospital
RECRUITING

Lancaster, Pennsylvania, 17601, United States
Penn Medicine - Pennsylvania Hospital
RECRUITING

Philadelphia, Pennsylvania, 19106, United States
Penn Medicine - Perelman Center for Advanced Medicine
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Penn Medicine - Princeton Health
RECRUITING

Plainsboro, New Jersey, 08536, United States
Presbyterian Kaseman Hospital
RECRUITING

Albuquerque, New Mexico, 87110, United States
Presbyterian Rust Medical Center/Jorgensen Cancer Center
RECRUITING

Rio Rancho, New Mexico, 87124, United States
SC Cancer Specialists - Hilton Head at St. Joseph's/Candler
RECRUITING

Hilton Head Island, South Carolina, 29926, United States
Smilow Cancer Hospital - Waterford
RECRUITING

Waterford, Connecticut, 06385, United States
Smilow Cancer Hospital - Westerly
RECRUITING

Westerly, Rhode Island, 02891, United States
Smilow Cancer Hospital - Yale New Haven Health
RECRUITING

New Haven, Connecticut, 06510, United States
Smilow Cancer Hospital Care Center - Derby
RECRUITING

Derby, Connecticut, 06418, United States
Smilow Cancer Hospital Care Center - Fairfield
RECRUITING

Fairfield, Connecticut, 06824, United States
Smilow Cancer Hospital Care Center - Greenwich
RECRUITING

Greenwich, Connecticut, 06830, United States
Smilow Cancer Hospital Care Center - Guilford
RECRUITING

Guilford, Connecticut, 06437, United States
Smilow Cancer Hospital Care Center - North Haven
RECRUITING

North Haven, Connecticut, 06473, United States
Smilow Cancer Hospital Care Center - Torrington
RECRUITING

Torrington, Connecticut, 06790, United States
Smilow Cancer Hospital Care Center - Trumbull
RECRUITING

Trumbull, Connecticut, 06611, United States
Smilow Cancer Hospital Care Center - Waterbury
RECRUITING

Waterbury, Connecticut, 06708, United States
Smilow Cancer Hospital at Glastonbury
RECRUITING

Glastonbury, Connecticut, 06033, United States
Smilow Cancer Hospital at Saint Francis
RECRUITING

Hartford, Connecticut, 06105, United States
St. Joseph's Candler Bluffton Campus
RECRUITING

Bluffton, South Carolina, 29910, United States
The Jackson Laboratory (JAX) - Harold Alfond Center for Cancer Care
RECRUITING

Augusta, Maine, 04330, United States
The Jackson Laboratory (JAX) - Northern Light Cancer Care
RECRUITING

Brewer, Maine, 04412, United States
The University of Kansas Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
The University of New Mexico Comprehensive Cancer Center
RECRUITING

Albuquerque, New Mexico, 87131, United States
UCHealth Cherry Creek Medical Center
RECRUITING

Denver, Colorado, 80206, United States
UCHealth Highlands Ranch Hospital
RECRUITING

Highlands Ranch, Colorado, 80129, United States
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
Yale University/Yale Cancer Center/Yale School of Medicine
RECRUITING

New Haven, Connecticut, 06510, United States

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