New umbrella study aims to match breast cancer patients with best drug cocktail

NCT ID NCT03424005

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 13, 2026 · Updated 5 times

Summary

This study is testing many different drug combinations in people with metastatic breast cancer that has spread or cannot be removed by surgery. Researchers are looking at which combinations work best for different cancer types, such as triple-negative or hormone receptor-positive. The goal is to improve response rates and control the disease longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Capecitabine, Atezolizumab, and other drug combinations
What this could lead to: If successful, this could identify better treatment combinations for different types of metastatic breast cancer, potentially improving survival and quality of life.
What could go wrong: This is an early-phase (1b/2) study, so results are preliminary. Many combinations may not work better than current treatments, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm HER2 positive breast carcinoma Her2-receptor negative breast cancer hormone receptor-positive breast cancer invasive breast carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC BREAST CANCER

Contacts and locations

Locations

Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Assuta Medical Centers
RECRUITING

Tel Aviv, 69710, Israel
Barts Health NHS Trust - St Bartholomew's Hospital
COMPLETED

London, EC1A 7BE, United Kingdom
Beatson West of Scotland Cancer Centre
COMPLETED

Glasgow, G12 0YN, United Kingdom
Centre Léon Bérard
COMPLETED

Lyon, 69008, France
Centro Integral Oncológico Clara Campal Ensayos Clínicos START
RECRUITING

Madrid, 28050, Spain
City of Hope
COMPLETED

Duarte, California, 91010, United States
Duke Cancer Institute
RECRUITING

Durham, North Carolina, 27710-2000, United States
Fiona Stanley Hospital - Medical Oncology
RECRUITING

Murdoch, Western Australia, 6150, Australia
Gustave Roussy
RECRUITING

Villejuif, 94805, France
H. Lee Moffitt Cancer Center and Research Inst.
COMPLETED

Tampa, Florida, 33612, United States
Hackensack Univ Medical Center
WITHDRAWN

Hackensack, New Jersey, 07601, United States
Hadassah University Medical Center
RECRUITING

Jerusalem, 91120, Israel
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, Sevilla, 41009, Spain
Hospital del Mar
RECRUITING

Barcelona, 08003, Spain
Institut Universitaire du Cancer de Toulouse-Oncopole
RECRUITING

Toulouse, 31059, France
Institut régional du Cancer Montpellier
WITHDRAWN

Montpellier, 34298, France
Metro-Minnesota Community Oncology Research Consortium
RECRUITING

Saint Paul, Minnesota, 55101-2502, United States
NYU Langone Medical Center
WITHDRAWN

New York, New York, 10016, United States
National Cancer Center Clinical Trials Center / Center for Breast Cancer
RECRUITING

Goyang-si, 410-769, South Korea
National Cheng Kung University Hospital
RECRUITING

Tainan, 704302, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 100, Taiwan
Peter MacCallum Cancer Centre-East Melbourne
RECRUITING

Melbourne, Victoria, 3000, Australia
Rabin MC
RECRUITING

Petah Tikva, 55900, Israel
Rambam Medical Center
RECRUITING

Haifa, 3109601, Israel
Regional Cancer Care Associates, LLC
WITHDRAWN

Howell Township, New Jersey, 07731, United States
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502-1576, United States
Rocky Mountain Cancer Center - Longmont
COMPLETED

Longmont, Colorado, 80501, United States
Rutgers Cancer Institute of New Jersey
WITHDRAWN

New Brunswick, New Jersey, 08901, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital
RECRUITING

Seoul, 03722, South Korea
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
Sheba Medical Center
RECRUITING

Ramat Gan, 5262100, Israel
Stanford Cancer Institute
WITHDRAWN

Stanford, California, 94305, United States
Tel-Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
Tennessee Oncology - Chattanooga Oncology & Hematology Associates
RECRUITING

Chattanooga, Tennessee, 37404, United States
Tennessee Oncology PLLC
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Oncology-Plano East
WITHDRAWN

Plano, Texas, 75075-7787, United States
The West Clinic
RECRUITING

Germantown, Tennessee, 38138, United States
Thomas Jefferson University Hospital
WITHDRAWN

Philadelphia, Pennsylvania, 19107, United States
University of California San Diego (UCSD) - Koman Family Outpatient Pavilion ? La Jolla
RECRUITING

La Jolla, California, 92093-1350, United States
University of California San Diego Medical Center
COMPLETED

La Jolla, California, 92093, United States
University of Pittsburgh Medical Center
WITHDRAWN

Pittsburgh, Pennsylvania, 15213, United States
Universitätsklinikum Erlangen
RECRUITING

Erlangen, 91054, Germany
Universitätsklinikum Essen
RECRUITING

Essen, 45147, Germany
Vall d?Hebron Institute of Oncology (VHIO), Barcelona
RECRUITING

Barcelona, 08035, Spain
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37212, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.