New pill could ease diabetic nerve pain in landmark trial

NCT ID NCT06619860

Recruiting now Symptom relief Sponsor: Vertex Pharmaceuticals Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This Phase 2 trial tests an experimental oral drug called VX-993 for pain caused by diabetic peripheral neuropathy, a common complication of diabetes. About 300 adults with type 1 or type 2 diabetes and nerve pain in both legs for at least a year will receive VX-993, pregabalin (a standard treatment), or placebo for 12 weeks. The main goal is to see if VX-993 reduces daily pain intensity more than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

VX-993 (oral tablet)

What this could lead to

If successful, VX-993 could offer a new option for managing chronic nerve pain in people with diabetes, potentially with fewer side effects than current treatments.

What could go wrong

This is an early Phase 2 trial with only 300 participants. The drug may not reduce pain better than existing treatments or placebo, and side effects are still being evaluated.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

diabetic neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC PERIPHERAL NEUROPATHIC PAIN

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AMR Fort Myers (The Clinical Study Center)
COMPLETED

Fort Myers, Florida, 33912, United States
AMR Norfolk
COMPLETED

Norfolk, Virginia, 23502, United States
Accel Research - Decatur
COMPLETED

Decatur, Georgia, 30030, United States
Accel Research - Deland
COMPLETED

DeLand, Florida, 32720, United States
Altasciences - Beaumont Clinic Montreal
RECRUITING

Montreal, Canada
Atlanta Center for Medical Research
COMPLETED

Atlanta, Georgia, 30331, United States
Birmingham Heartlands Hospital - Heartlands Hospital Diabetes Centre and MIDRU
RECRUITING

Birmingham, United Kingdom
CHU de Nîmes - Pain Assessment and Treatment Center
RECRUITING

Nîmes, France
Centre Hospitalier Universitaire de Clermont-Ferrand - Site Gabriel-Montpied
RECRUITING

Clermont-Ferrand, France
Centricity Research Brampton
RECRUITING

Brampton, Canada
Clinical Trials of South Carolina - Berkeley - Moncks Corner
COMPLETED

Moncks Corner, South Carolina, 29461, United States
Cullman Clinical Trials
COMPLETED

Cullman, Alabama, 35055, United States
Eximia Research - Raleigh
COMPLETED

Raleigh, North Carolina, 27607, United States
Eximia Research - San Diego
COMPLETED

La Mesa, California, 91942, United States
Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITING

Milan, Italy
FutureMeds Birmingham
RECRUITING

Birmingham, United Kingdom
FutureMeds Frankfurt
RECRUITING

Offenbach/Main, Germany
FutureMeds Glasgow
RECRUITING

Glasgow, United Kingdom
FutureMeds GmbH
RECRUITING

Berlin, Germany
Gadolin Research
COMPLETED

Beaumont, Texas, 77702, United States
George Eliot Hospital NHS Trust
RECRUITING

Nuneaton, United Kingdom
Health Awareness, Inc. - Port St. Lucie
COMPLETED

Port Saint Lucie, Florida, 34952, United States
Health Awareness, Inc., Jupiter
COMPLETED

Jupiter, Florida, 33458, United States
Healthcare Research Network - Flossmoor IL
COMPLETED

Flossmoor, Illinois, 604773027, United States
Healthcare Research Network - Hazelwood MO
COMPLETED

Hazelwood, Missouri, 63042, United States
Hopital Cochin - Rheumatology
RECRUITING

Paris, France
IRCCS Ospedale San Raffaele - InSpe and Division of Neuroscience
RECRUITING

Milan, Italy
Innovation Medical Research Center - Palmetto
COMPLETED

Palmetto Bay, Florida, 33157, United States
Manchester Diabetes Centre (MDC)
RECRUITING

Manchester, United Kingdom
Mount Sinai Hospital - Leadership Sinai Centre for Diabetes (LSCD)
RECRUITING

Toronto, Canada
Ninewells Hospital - Endocrinology
RECRUITING

Dundee, United Kingdom
North Hospital
RECRUITING

Saint-Priest-en-Jarez, France
OCT Research ULC
RECRUITING

Kelowna, Canada
Paradigm Clincial Research Centers, LLC., Wheat Ridge
COMPLETED

Wheat Ridge, Colorado, 80033, United States
Quest Research Institute
COMPLETED

Farmington Hills, Michigan, 48334, United States
Royal Hallamshire Hospital - Endocrinology
RECRUITING

Sheffield, United Kingdom
Ruhr-Universitaet Bochum - Heart and Diabetes Center
RECRUITING

Bad Oeynhausen, Germany
San Antonio Clinical Trials
COMPLETED

San Antonio, Texas, 78240, United States
St Pancras Clinical Research
RECRUITING

London, United Kingdom
Suncoast Research Associates - Miami
COMPLETED

Miami, Florida, 33172, United States
Trovare Clinical Research - Bakersfield CA
COMPLETED

Bakersfield, California, 93301, United States
University of Liverpool - Aintree University Hospital
RECRUITING

Liverpool, United Kingdom
Velocity Clinical Research - Boise
COMPLETED

Meridian, Idaho, 83642, United States
Velocity Clinical Research - Cleveland
COMPLETED

Beachwood, Ohio, 44122, United States
Velocity Clinical Research - Hallandale Beach
COMPLETED

Hallandale, Florida, 33009, United States
Velocity Clinical Research - Providence
COMPLETED

East Greenwich, Rhode Island, 02818, United States
Velocity Clinical Research, Dallas
COMPLETED

Dallas, Texas, 75230, United States