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Can a vitamin b derivative beat standard b vitamins for diabetic nerve pain?

NCT ID NCT07708233

Recruiting now Symptom relief Sponsor: Thammasat University Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 22, 2026 · Updated 3 times

Summary

This study tests whether benfotiamine, a form of vitamin B1, works better than a combination of vitamins B1, B6, and B12 at reducing numbness, pain, and other sensory nerve symptoms in people with diabetic peripheral neuropathy. Participants take either benfotiamine or the vitamin mix twice daily for 12 weeks, and neither they nor their doctors know which they receive. The goal is to see if benfotiamine provides greater relief from these common, uncomfortable nerve symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
benfotiamine and vitamin B1-6-12
What this could lead to
If benfotiamine proves more effective, it could offer a better option for managing painful nerve symptoms in people with diabetes.
What could go wrong
This is a small, short-term study (66 people, 12 weeks). Results may not apply to everyone, and benefits may be modest or no better than the vitamin combination.

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Conditions

The condition(s) this trial relates to.

diabetic neuropathy diabetic polyneuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC PERIPHERAL NEUROPATHY (DPN)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Thammasat University Hospital

    RECRUITING

    Pathumthani, Bangkok, 12120, Thailand

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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