Diabetic neuropathy

This completed study tested whether lotus seed capsules could improve nerve health, blood sugar, and immune function in 60 people with type 2 diabetes and nerve damage. Participants took either lotus seed or placebo capsules for 9 months alongside their regular diabetes treatment…

This study tested whether custom silicone toe orthoses (inserts) could reduce foot pressure and prevent pre-ulcerative lesions in people with diabetic neuropathy. Sixty participants with diabetes and foot deformities wore the orthoses for six months. The goal was to see if these …

This small study tested whether injecting a person's own fat-derived cells (called stromal vascular fraction) into the foot could help heal diabetic nerve damage and foot ulcers. Eight adults with diabetic peripheral neuropathy received injections around the wound and along nerve…

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study looked at whether a 12-week intensive lifestyle program focused on weight loss and diabetes control could improve diabetic peripheral neuropathy, a common nerve complication. Fifty adults with diabetes and a BMI between 30 and 45 took part. The program included diet, e…

This study tested whether using a computer model to adjust doses of two common drugs (sitagliptin for diabetes and duloxetine for nerve pain) works better in people with liver cirrhosis. 64 patients with cirrhosis, diabetes, and nerve pain were grouped by liver severity and given…

This study tested two simple bedside tools—the Neuropathy Disability Score and Neuropathy Symptom Score—to screen for diabetic nerve damage. Researchers compared them to standard nerve tests in 228 adults with diabetes. The goal was to see if these easy-to-use tools could help de…

This study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…

This study tests whether inhaling medical cannabis three times a day can safely reduce pain in people with diabetic peripheral neuropathy. 122 adults will receive either a low, medium, or high dose of THC or a placebo using a special inhaler. The main goal is to see if pain score…

This study tested whether teaching good sleep habits could help people with painful diabetic nerve damage sleep better and feel better overall. Twenty-four patients were split into two groups: one received a booklet and face-to-face sleep training from a nurse, while the other co…

This study tested whether a new type of brain stimulation, called controlled transcranial magnetic stimulation (cTMS), can reduce pain and improve daily function in people with painful diabetic neuropathy. Twenty adults with the condition received either real or sham cTMS over fi…

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This small pilot study tested whether a 4-week course of repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain and improve quality of life in 18 adults with diabetic neuropathy. Participants received rTMS and were monitored using questionnaires, nerve tests, a…

This study tested whether a spinal cord stimulation device can reduce chronic leg pain caused by diabetic neuropathy. Twenty-eight people with diabetes received the implant and reported their pain relief and overall improvement over 12 months. The goal was to see if this device c…

This study tested two non-invasive treatments—low-level laser and transcutaneous vagus nerve stimulation—in 30 adults with diabetic neuropathy. The goal was to see which better improves blood flow and reduces nerve pain. Participants had diabetes for over 5 years and stable blood…

This study tested whether combining balance exercises with mental tasks (like naming animals) can improve balance and mild memory problems in people with diabetic nerve damage. Fifty adults aged 50 and older with type 2 diabetes and mild cognitive issues took part in 24 sessions …

This study tested whether adding a four-cell galvanic bath therapy to standard rehabilitation could reduce pain and improve balance in people with diabetic nerve damage. 66 adults with type 2 diabetes and diabetic neuropathy participated. Over 4 weeks, some received the bath ther…

This study tested whether a special set of exercises, called modified Otago exercises, could help people with type 2 diabetes who have nerve damage in their feet. 38 participants did these exercises for 8 weeks, and researchers measured their balance, joint position sense, blood …

This study looked at whether adding foot exercises to aerobic exercise helps people with type 2 diabetes and nerve damage in their legs. 74 participants were split into three groups: usual medical care, aerobic exercise only, or aerobic exercise plus foot exercises. The goal was …

This study looked at whether a diabetes education program plus cinnamon supplements could help adults with type 2 diabetes who have painful nerve damage in their feet. Sixty-two participants were split into two groups and followed for six months. Researchers measured changes in b…

This study tested several experimental treatments for painful diabetic peripheral neuropathy, a common complication of diabetes that causes burning or shooting pain in the feet and hands. 127 adults with this condition rated their daily pain on a 0-10 scale to see if the treatmen…

This study tested whether a daily capsule called NRD135S.E1 can safely reduce nerve pain caused by diabetes. 127 adults with painful diabetic neuropathy took either the drug or a placebo for 13 weeks. Researchers measured pain changes using a 0-10 scale and tracked any side effec…

This study tested whether a set of foot and ankle exercises could reduce pain and improve quality of life in 100 people with painful diabetic neuropathy. Participants performed exercises like ankle circles, toe spreads, and rolling a warm bottle under the foot. Researchers measur…

This study tested whether the diabetes drug acarbose, adjusted using continuous glucose monitoring (CGM), can reduce pain in adults with painful diabetic neuropathy. 170 participants with type 2 diabetes and high blood sugar swings were enrolled. The goal was to see if controllin…

This study tested whether adding sensory integration exercises (like brushing and textured balls on the feet) to standard exercises could improve body awareness and balance in people with diabetic nerve damage. Thirty participants with moderate nerve damage were split into two gr…

This study tested a combined laser and ultrasound treatment for people with type 2 diabetes who have early nerve damage in their feet. Sixty participants received either the real treatment or a placebo over 24 sessions. The results showed that the treatment helped reduce pain, bu…

This study tested whether adding thymoquinone, a compound from black seed oil, to the standard pain drug pregabalin could better relieve nerve pain in people with diabetes. Fifty adults with diabetic peripheral neuropathy took both treatments daily for two months. Researchers mea…

This study looked at whether supervised exercise training is better than unsupervised exercise for improving balance and quality of life in people with diabetic nerve damage in their feet and legs. 32 adults aged 55-70 with type 2 diabetes for at least 10 years took part. The goa…

This study tested an experimental drug called MT-8554 in 61 adults with painful diabetic peripheral neuropathy, a common complication of diabetes causing nerve pain. The goal was to see if the drug could safely reduce pain compared to a placebo. Participants took the drug or plac…

This study tested a drug called MT-8554 (Elismetrep) in 156 adults with painful diabetic peripheral neuropathy. The goal was to see if it reduces pain better than a placebo over 12 weeks. Participants took either the drug or a placebo capsule, and pain was measured using a 0-10 s…

This study tested if people with painful diabetic neuropathy can safely use a new electrical stimulation device at home. 40 adults who had not gotten enough relief from standard pain medicines used the device for 10 days. The goal was to see if the device is easy to use and has s…

This pilot study tested whether a structured foot-ankle exercise program could help adults with type 2 diabetes manage nerve pain, stress, and quality of life, compared to walking or standard care. Over 12 weeks, 108 participants either did foot-ankle exercises, walked regularly,…

This study tested whether foot-ankle exercises and walking exercises can reduce foot nerve pain, stress, and improve quality of life in people with type 2 diabetes. 375 adults with diabetes were split into three groups: foot-ankle exercises, walking exercises, or standard care. T…

This study followed 101 people who had previously received either the experimental drug Engensis or a placebo for painful diabetic neuropathy. No new treatment was given; researchers simply monitored participants for 6 months to see if any safety issues or lasting pain relief app…

This Phase 3 study tested whether injections of engensis, a gene therapy, can reduce pain in the feet and legs caused by diabetic nerve damage. 162 adults with type 1 or 2 diabetes received either engensis or a placebo. The main goal was to see if pain scores improved over 180 da…

This study tested whether a gene therapy called VM202 could safely reduce pain in people with diabetic peripheral neuropathy. Over 500 adults with type 1 or type 2 diabetes received either VM202 injections or a placebo in their legs. The main goal was to see if the treatment lowe…

This study tested a drug called LX9211 in 496 adults with diabetic peripheral neuropathic pain (nerve pain from diabetes). The goal was to see if it reduces average daily pain and improves sleep compared to a placebo over 8 weeks. The trial is complete, and results will show if L…

This study tested whether a gene therapy called engensis can safely reduce pain from diabetic nerve damage over 6 to 12 months. About 100 people who completed an earlier trial received either engensis or placebo injections into their leg muscles. Researchers measured changes in d…

This early-phase trial tested a gene therapy called Engensis (VM202) in 12 people with painful diabetic peripheral neuropathy. Participants received injections into their calf muscles to see if it was safe and could reduce pain. The study focused on safety and pain scores over 12…

This study tested a gene therapy called Engensis (VM202) to see if it safely reduces pain in people with diabetic peripheral neuropathy. 104 adults with type 1 or 2 diabetes and leg pain for at least 6 months received either low-dose, high-dose, or placebo injections into their c…

This study tested a cream containing cannabidiol (CBD) and urea on 23 adults with diabetic foot neuropathy and dry skin. The goal was to see if it could reduce nerve pain and improve skin quality. While the treatment aims to ease symptoms, it does not cure the underlying diabetes…

This study looked at two ways to help people with diabetic nerve pain in their legs: high-intensity laser therapy and moderate aerobic exercise. Sixty adults with symptoms like numbness, tingling, or burning took part. The goal was to see which approach improves leg function and …

This study looks at tiny nerve fibers in the skin of people with Long COVID, POTS, diabetic neuropathy, and those who had COVID-19 without lasting symptoms. By comparing skin samples, researchers hope to find unique patterns that help explain ongoing symptoms like pain and dizzin…

This completed study from Denmark looked at 101 people to see if nerve damage from type 2 diabetes is linked to memory and thinking problems. Researchers compared people with and without diabetes using tests of thinking skills, nerve function, and brain scans. The goal was to und…

This study looked at how a nerve condition called cardiovascular autonomic neuropathy (CAN) affects the risk of kidney injury in people having heart bypass surgery. Researchers tracked 912 adults before, during, and after surgery to see if those with CAN had worse kidney function…

This completed observational study looked at 84 people to understand how diabetic polyneuropathy (nerve damage from diabetes) changes the median nerve in patients with carpal tunnel syndrome. Researchers used advanced ultrasound techniques, including shear wave elastography and m…

This study looked at how different shoe fit guidelines affect pressure inside the shoe for people with diabetes and nerve damage. Researchers measured foot pressure while 26 participants walked in standardized shoes with different toe gap sizes. The goal was to see which fit guid…

This study looked at whether special rocker sole shoes cause balance problems in people with type 2 diabetes and nerve damage in their feet. 25 adults completed the trial. Researchers measured how much people swayed while standing still in the special shoes.

This study looked at whether using telemedicine (video or phone consultations) can help people in rural communities with leg wounds get specialist care more quickly. Researchers compared the time from when a wound was found to when a specialist saw the patient, either through tel…