New hope for diabetic nerve pain: platform trial tests multiple treatments

NCT ID NCT05476276

First seen Jan 04, 2026 · Last updated May 08, 2026 · Updated 22 times

Summary

This completed Phase 2 trial tested several experimental treatments for painful diabetic peripheral neuropathy (PDPN), a common complication of diabetes causing nerve pain. 127 adults with PDPN rated their daily pain on a 0-10 scale to see if the treatments helped. The goal was to find safe and effective options to ease this chronic pain.

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Contacts and locations

Locations

  • Clinical Inquest Center

    Beavercreek, Ohio, 45431, United States

  • Columbia University Medical Center/Neurological Institute

    New York, New York, 10032, United States

  • Eastern Virginia Medical School

    Norfolk, Virginia, 23510, United States

  • Healthcare Research Network (Flossmoor)

    Flossmoor, Illinois, 60422, United States

  • Healthcare Research Network (Hazelwood)

    Hazelwood, Missouri, 63042, United States

  • Johns Hopkins University School of Medicine

    Baltimore, Maryland, 21205, United States

  • Low Country Pain Center

    Orangeburg, South Carolina, 29118, United States

  • MGH Department of Anesthesia, Critical Care, and Pain

    Boston, Massachusetts, 02114, United States

  • Mount Sinai School of Medicine

    New York, New York, 10451, United States

  • Nerve and Muscle Center of Texas

    Houston, Texas, 77030, United States

  • Northwestern Department of Neurology

    Chicago, Illinois, 60611, United States

  • SIMEDHealth LLC

    Gainesville, Florida, 32607, United States

  • South Lake Pain Institute

    Clermont, Florida, 34711, United States

  • University of California, San Diego

    San Diego, California, 92037, United States

  • University of Florida

    Gainesville, Florida, 32611, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • University of Maryland - Baltimore

    Baltimore, Maryland, 21201, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15206, United States

  • University of Rochester

    Rochester, New York, 14627, United States

  • University of Utah School of Medicine

    Salt Lake City, Utah, 84132, United States

  • University of Washington

    Seattle, Washington, 32611, United States

  • University of Wisconsin

    Madison, Wisconsin, 53706, United States

  • VCU Department of Neurology

    Richmond, Virginia, 23298, United States

Conditions

Explore the condition pages connected to this study.