Gene therapy shot may ease diabetic foot pain for a year
NCT ID NCT04873232
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a gene therapy called engensis can safely reduce pain from diabetic nerve damage over 6 to 12 months. About 100 people who completed an earlier trial received either engensis or placebo injections into their leg muscles. Researchers measured changes in daily pain scores to see if the treatment provides lasting relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Engensis (a gene therapy given as injections into the leg muscles)
What this could lead to
If it works, this could provide lasting pain relief for people with diabetic nerve pain in the feet and legs.
What could go wrong
This is an extension study building on earlier results, so the main findings are still being analyzed. Pain relief may not be durable or may not differ from placebo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Arizona Research Center
Phoenix, Arizona, 85053, United States
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California Medical Clinic for Headache
Los Angeles, California, 90048, United States
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ClinPoint Trials LLC
Waxahachie, Texas, 75165, United States
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Clinical Research Professionals
Chesterfield, Missouri, 63005, United States
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Clinical Trials - Little Rock
Little Rock, Arkansas, 72205, United States
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Clinical Trials Research - Sacramento
Sacramento, California, 95821, United States
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Dominion Medical Associates
Richmond, Virginia, 23219, United States
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Eastern Virginia Medical School
Norfolk, Virginia, 23510, United States
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Foot & Ankle Center of Illinois
Springfield, Illinois, 62704, United States
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Futuro Clinical Trials
McAllen, Texas, 78501, United States
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Gateway Clinical Trials, LLC
O'Fallon, Illinois, 62269, United States
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Health Concepts
Rapid City, South Dakota, 57702, United States
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Innovative Research of West Florida, Inc.
Clearwater, Florida, 33756, United States
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Manassas Clinical Research Center
Manassas, Virginia, 20110, United States
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Nerve and Muscle Center of Texas
Houston, Texas, 77030, United States
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Richmond Behavioral Associates
Staten Island, New York, 10314, United States