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Hidden nerve damage may disrupt Heart's electrical activity during surgery

NCT ID NCT07684768

Knowledge-focused Sponsor: Haseki Training and Research Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study looks at whether cardiac autonomic neuropathy (nerve damage that affects heart rate control) changes the heart's electrical recovery time (QT interval) in people having coronary artery bypass surgery. Researchers will test nerve function before surgery and measure heart rhythm at several points during and after the operation. The goal is to see if patients with this nerve condition are more likely to have dangerous heart rhythm changes during surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If cardiac autonomic neuropathy is shown to prolong QT intervals during surgery, it could help doctors identify high-risk patients and adjust monitoring or care to prevent dangerous heart rhythms.
What could go wrong
This is a small observational study, not a treatment trial. It can only suggest a link, not prove cause and effect. Results may not apply to all heart surgery patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

60 people

The number who actually took part.

Started

Oct 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients scheduled for elective isolated coronary artery bypass grafting (CABG) surgery under general anesthesia at a tertiary care university hospital.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years. * Scheduled for elective isolated coronary artery bypass grafting (CABG). * Sinus rhythm on preoperative 12-lead electrocardiography. * Ability to undergo preoperative cardiovascular autonomic function assessment using Ewing's cardiovascular reflex tests. * Written informed consent provided. Exclusion Criteria: * Previous cardiac surgery. * Emergency CABG. * Permanent pacemaker implantation. * Atrial fibrillation or other clinically significant cardiac arrhythmias. * Bundle branch block. * Congenital long QT syndrome.

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Conditions

The condition(s) this trial relates to.

Arrhythmias, Cardiac autonomic neuropathy coronary artery disorder diabetic autonomic neuropathy long QT syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac autonomic neuropathy Coronary artery disease QT interval prolongation

Contacts and locations

Locations

  • Health Science University, Haseki Training and Research Hospital

    Istanbul, Turkey (Türkiye)

  • Sultangazi Haseki Training and Research Hospital

    Istanbul, 34265, Turkey (Türkiye)

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