New pill could ease diabetic nerve pain

NCT ID NCT05123196

Completed Symptom relief Sponsor: Tanabe Pharma Corporation Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a drug called MT-8554 (Elismetrep) in 156 adults with painful diabetic peripheral neuropathy. The goal was to see if it reduces pain better than a placebo over 12 weeks. Participants took either the drug or a placebo capsule, and pain was measured using a 0-10 scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MT-8554 (Elismetrep) oral capsule
What this could lead to: If it works, this could lead to a new pain relief option for people with diabetic nerve pain.
What could go wrong: This is an early Phase 2 trial with only 156 participants, so results may not apply to everyone. The drug may not reduce pain better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diabetic neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAINFUL DIABETIC PERIPHERAL NEUROPATHY

Contacts and locations

Locations

Abe Diabetes Clinic

Ōita, Oita Prefecture, 870-0039, Japan
Hakodate Central General Hospital

Hakodate, Hokkaido, 040-8585, Japan
Hisatomi Clinic

Saga, Saga-ken, 849-0937, Japan
JUNEIKAI Medical Corporation Akaicho Clinic

Chiba, Chiba, 260-0804, Japan
Japan Organization of Occupational Health and Safety Chubu Rosai Hospital

Nagoya, Aichi-ken, 455-8530, Japan
Japan Organization of Occupational Health and Safety Sanin Rosai Hospital

Yonago, Tottori, 683-8605, Japan
Japanese Red Cross Asahikawa Hospital

Asahikawa, Hokkaido, 070-8530, Japan
Jiyugaoka Yamada Internal Medicine Clinic

Obihiro, Hokkaido, 080-0848, Japan
Kikuchi Clinic of Internal Medicine

Maebashi, Gunma, 370-3573, Japan
Kitano Hospital, Tazuke Kofukai Medical Research Institute

Osaka, 530-8480, Japan
Kumanomae Nishimura Naika Clinic

Arakawa-ku, Tokyo, 116-0012, Japan
Kunisaki Makoto Clinic

Fukuoka, Fukuoka, 819-0168, Japan
Matsunami Health Promotion Clinic

Hashima-gun, Gifu, 501-6061, Japan
Medical Corporation Heishinkai OCROM Clinic

Suita, Osaka, 565-0853, Japan
Medical Corporation Heishinkai ToCROM Clinic

Shinjuku-ku, Tokyo, 160-0008, Japan
Medical Corporation Ikeikai Inobe Funai Clinic

Ōita, Oita Prefecture, 870-0021, Japan
Medical Corporation Keiaikai Nakamura Hospital

Beppu, Oita Prefecture, 874-0937, Japan
Medical Corporation Kouhoukai Takagi Hospital

Okawa-shi, Fukuoka, 831-0016, Japan
Medical Corporation Souaikai Aihara Medical Clinic

Shinagawa-ku, Tokyo, 142-0053, Japan
OMI MEDICAL CENTER, Social Medical Corporation Seikoukai

Kusatsu, Shiga, 525-8585, Japan
Ome Municipal General Hospital

Ome-shi, Tokyo, 198-0042, Japan
Saiki Central Hospital

Saiki, Oita Prefecture, 876-0851, Japan
Sanuki Municipal Hospital

Sanuki-shi, Kagawa-ken, 769-2393, Japan
Shonan Fujisawa Tokushukai Hospital

Fujisawa-shi, Kanagawa, 251-0041, Japan
Shunkaikai Inoue Hospital

Nagasaki, Nagasaki, 850-0045, Japan
Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital

Fukuoka, Fukuoka, 811-0213, Japan
Soka Sugiura Internal Medicine Clinic

Sōka, Saitama, 340-0034, Japan
Steel Memorial Yawata Hospital

Kitakyushu-shi, Fukuoka, 805-0050, Japan
Sugawara Clinic

Nerima-ku, Tokyo, 177-0041, Japan
TOJITAMA thyroid and diabetes Clinic

Fukuoka, Fukuoka, 815-0033, Japan
Takamatsu Red Cross Hospital

Takamatsu, Kagawa-ken, 760-0017, Japan
Tokyo Center Clinic

Chuo-ku, Tokyo, 103-0028, Japan
Yachiyo Hospital

Anjo, Aichi-ken, 446-8510, Japan

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