Gene therapy shot aims to ease diabetic foot pain
NCT ID NCT04469270
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 study tested whether injections of engensis, a gene therapy, can reduce pain in the feet and legs caused by diabetic nerve damage. 162 adults with type 1 or 2 diabetes received either engensis or a placebo. The main goal was to see if pain scores improved over 180 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Engensis (a gene therapy given as injections into the muscle)
- What this could lead to
- If it works, this could provide a new option to reduce chronic nerve pain in people with diabetes.
- What could go wrong
- This is a Phase 3 trial, but results are not yet known. The treatment may not reduce pain better than a placebo, and injections carry risks like soreness or infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Arizona Research Center
Phoenix, Arizona, 85053, United States
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California Medical Clinic for Headache
Los Angeles, California, 90048, United States
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ClinPoint Trials LLC
Waxahachie, Texas, 75165, United States
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Clinical Research Professionals
Chesterfield, Missouri, 63005, United States
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Clinical Trials - Little Rock
Little Rock, Arkansas, 72205, United States
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Clinical Trials Research - Sacramento
Sacramento, California, 95821, United States
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Dominion Medical Associates
Richmond, Virginia, 23219, United States
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Eastern Virginia Medical School
Norfolk, Virginia, 23510, United States
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Foot & Ankle Center of Illinois
Springfield, Illinois, 62704, United States
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Futuro Clinical Trials, LLC
McAllen, Texas, 78501, United States
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Gateway Clinical Trials, LLC
O'Fallon, Illinois, 62269, United States
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Health Concepts
Rapid City, South Dakota, 57702, United States
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Innovative Research of West Florida, Inc.
Clearwater, Florida, 33756, United States
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Manassas Clinical Research Center
Manassas, Virginia, 20110, United States
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Nerve and Muscle Center of Texas
Houston, Texas, 77030, United States
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Richmond Behavioral Associates
Staten Island, New York, 10314, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.