New pill aims to calm burning nerve pain in diabetes

NCT ID NCT06203002

Completed Symptom relief Sponsor: Lexicon Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 30 times

Summary

This study tested an experimental drug called LX9211 to see if it can reduce pain caused by nerve damage from diabetes. About 496 adults with diabetic nerve pain took either the drug or a placebo for 8 weeks. The main goal was to see if the drug lowers average daily pain scores better than a placebo.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Lexicon Investigational Site (101)

Salt Lake City, Utah, 84102, United States
Lexicon Investigational Site (102)

Tucson, Arizona, 85741, United States
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Winter Park, Florida, 32789, United States
Lexicon Investigational Site (104)

Hazelwood, Missouri, 63042, United States
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New Port Richey, Florida, 34652, United States
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Morehead City, North Carolina, 28557, United States
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Anaheim, California, 92801, United States
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Dearborn, Michigan, 48126, United States
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Fort Myers, Florida, 33912, United States
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Williamsville, New York, 14221, United States
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Sacramento, California, 95821, United States
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Greenbrae, California, 94904, United States
Lexicon Investigational Site (113)

Greenville, South Carolina, 29607, United States
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Flower Mound, Texas, 75028, United States
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Chandler, Arizona, 85286, United States
Lexicon Investigational Site (116)

Papillion, Nebraska, 68046, United States
Lexicon Investigational Site (119)

Brandon, Florida, 33511, United States
Lexicon Investigational Site (120)

Houston, Texas, 77030, United States
Lexicon Investigational Site (121)

Boston, Massachusetts, 02115, United States
Lexicon Investigational Site (122)

Westfield, New York, 14787, United States
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Ormond Beach, Florida, 32174, United States
Lexicon Investigational Site (124)

Tustin, California, 92780, United States
Lexicon Investigational Site (125)

Ann Arbor, Michigan, 48109, United States
Lexicon Investigational Site (126)

Sacramento, California, 95821, United States
Lexicon Investigational Site (128)

Anniston, Alabama, 36207, United States
Lexicon Investigational Site (129)

San Diego, California, 92103, United States
Lexicon Investigational Site (130)

Manassas, Virginia, 20110, United States
Lexicon Investigational Site (131)

Winter Haven, Florida, 33880, United States
Lexicon Investigational Site (132)

Flossmoor, Illinois, 60422, United States
Lexicon Investigational Site (133)

The Villages, Florida, 32159, United States
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The Villages, Florida, 32162, United States
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Olive Branch, Mississippi, 38654, United States
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New Bedford, Massachusetts, 02740, United States
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New York, New York, 100029, United States
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Orlando, Florida, 32806, United States
Lexicon Investigational Site (145)

Winston-Salem, North Carolina, 27103, United States
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Orlando, Florida, 32801, United States
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Norman, Oklahoma, 73069, United States
Lexicon Investigational Site (150)

Atlanta, Georgia, 30303, United States
Lexicon Investigational Site (151)

Marietta, Georgia, 30060, United States
Lexicon Investigational Site (152)

Houston, Texas, 77074, United States
Lexicon Investigational Site (153)

Euless, Texas, 76040, United States
Lexicon Investigational Site (154)

San Diego, California, 92120, United States
Lexicon Investigational Site (155)

Lewisville, Texas, 75057, United States
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St Louis, Missouri, 63110, United States
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Summerville, South Carolina, 29486, United States
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Dallas, Texas, 75231, United States
Lexicon Investigational Site (159)

San Antonio, Texas, 78233, United States
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Memphis, Tennessee, 38119, United States
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Fresno, California, 93710, United States
Lexicon Investigational Site (162)

Las Vegas, Nevada, 89123, United States
Lexicon Investigational Site (163)

Lomita, California, 90717, United States
Lexicon Investigational Site (164)

Miami, Florida, 33176, United States
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Norfolk, Virginia, 23510, United States
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Schenectady, New York, 12304, United States
Lexicon Investigational Site (168)

Dayton, Ohio, 45424, United States
Lexicon Investigational Site (169)

Long Beach, California, 90806, United States
Lexicon Investigational Site (170)

New Orleans, Louisiana, 70115, United States
Lexicon Investigational Site (171)

Walnut Creek, California, 94596, United States
Lexicon Investigational Site (172)

Chicago, Illinois, 60623, United States
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Canoga Park, California, 91303, United States
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Kansas City, Missouri, 64114, United States
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Daytona Beach, Florida, 32117, United States
Lexicon Investigational Site (178)

Newton, Kansas, 67114, United States
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Escondido, California, 92025, United States
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Hollywood, Florida, 33024, United States
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Walnut Creek, California, 94598, United States
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Plantation, Florida, 33317, United States
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Charleston, South Carolina, 29406, United States
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Springfield, Missouri, 65807, United States
Lexicon Investigational Site (185)

El Dorado, Kansas, 67042, United States
Lexicon Investigational Site (186)

Wichita, Kansas, 67207, United States
Lexicon Investigational Site (187)

Eugene, Oregon, 97404, United States
Lexicon Investigational Site (188)

Jacksonville, Florida, 32256, United States
Lexicon Investigational Site (189)

Daphne, Alabama, 36526, United States
Lexicon Investigational Site (190)

New Orleans, Louisiana, 70119, United States
Lexicon Investigational Site (191)

Inglewood, California, 90301, United States
Lexicon Investigational Site (192)

Austin, Texas, 78759, United States
Lexicon Investigational Site (193)

Dallas, Texas, 75230, United States
Lexicon Investigational Site (194)

Brandon, Florida, 33511, United States
Lexicon Investigational Site (195)

Phoenix, Arizona, 85028, United States
Lexicon Investigational Site (196)

Harlingen, Texas, 78550, United States
Lexicon Investigational Site (197)

Houston, Texas, 77065, United States
Lexicon Investigational Site (198)

Fleming Island, Florida, 32003, United States
Lexicon Investigational Site (199)

Baytown, Texas, 77521, United States
Lexicon Investigational Site (200)

Asheville, North Carolina, 28803, United States
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Columbia, South Carolina, 29205, United States
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Rock Hill, South Carolina, 29730, United States
Lexicon Investigational Site (203)

San Antonio, Texas, 78229, United States
Lexicon Investigational Site (204)

Huntington Beach, California, 92647, United States
Lexicon Investigational Site (205)

North Charleston, South Carolina, 29405, United States
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Scottsdale, Arizona, 85258, United States
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Greensboro, North Carolina, 27410, United States
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Oklahoma City, Oklahoma, 73102, United States
Lexicon Investigational Site (211)

Vista, California, 92081, United States
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Monroe, North Carolina, 28112, United States
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Owensboro, Kentucky, 42303, United States
Lexicon Investigational Site (214)

Katy, Texas, 77494, United States
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Guntersville, Alabama, 35976, United States
Lexicon Investigational Site (216)

Las Vegas, Nevada, 89106, United States
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Salt Lake City, Utah, 84107, United States
Lexicon Investigational Site (220)

Beavercreek, Ohio, 45432, United States
Lexicon Investigational Site (221)

San Antonio, Texas, 78240, United States
Lexicon Investigational Site (222)

Birmingham, Alabama, 35216, United States
Lexicon Investigational Site (223)

Mesquite, Texas, 75150, United States
Lexicon Investigational Site (224)

St. George, Utah, 84790, United States
Lexicon Investigational Site (225)

Waltham, Massachusetts, 02451, United States
Lexicon Investigational Site (227)

Rochester, New York, 14609, United States

Conditions

Explore the condition pages connected to this study.

DIABETIC PERIPHERAL NEUROPATHIC PAIN