New drug LX9211 aims to ease diabetic nerve pain

NCT ID NCT06203002

Completed Symptom relief Sponsor: Lexicon Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called LX9211 in 496 adults with diabetic peripheral neuropathic pain (nerve pain from diabetes). The goal was to see if it reduces average daily pain and improves sleep compared to a placebo over 8 weeks. The trial is complete, and results will show if LX9211 is a promising option for this condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

LX9211

What this could lead to

If it works, this could point toward a new pain reliever for people with diabetic nerve pain.

What could go wrong

This is an early phase 2 trial, so results may not confirm effectiveness. The drug might not work better than placebo or could have side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

diabetic neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC PERIPHERAL NEUROPATHIC PAIN

Contacts and locations

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Locations

Lexicon Investigational Site (101)

Salt Lake City, Utah, 84102, United States
Lexicon Investigational Site (102)

Tucson, Arizona, 85741, United States
Lexicon Investigational Site (103)

Winter Park, Florida, 32789, United States
Lexicon Investigational Site (104)

Hazelwood, Missouri, 63042, United States
Lexicon Investigational Site (105)

New Port Richey, Florida, 34652, United States
Lexicon Investigational Site (106)

Morehead City, North Carolina, 28557, United States
Lexicon Investigational Site (107)

Anaheim, California, 92801, United States
Lexicon Investigational Site (108)

Dearborn, Michigan, 48126, United States
Lexicon Investigational Site (109)

Fort Myers, Florida, 33912, United States
Lexicon Investigational Site (110)

Williamsville, New York, 14221, United States
Lexicon Investigational Site (111)

Sacramento, California, 95821, United States
Lexicon Investigational Site (112)

Greenbrae, California, 94904, United States
Lexicon Investigational Site (113)

Greenville, South Carolina, 29607, United States
Lexicon Investigational Site (114)

Flower Mound, Texas, 75028, United States
Lexicon Investigational Site (115)

Chandler, Arizona, 85286, United States
Lexicon Investigational Site (116)

Papillion, Nebraska, 68046, United States
Lexicon Investigational Site (119)

Brandon, Florida, 33511, United States
Lexicon Investigational Site (120)

Houston, Texas, 77030, United States
Lexicon Investigational Site (121)

Boston, Massachusetts, 02115, United States
Lexicon Investigational Site (122)

Westfield, New York, 14787, United States
Lexicon Investigational Site (123)

Ormond Beach, Florida, 32174, United States
Lexicon Investigational Site (124)

Tustin, California, 92780, United States
Lexicon Investigational Site (125)

Ann Arbor, Michigan, 48109, United States
Lexicon Investigational Site (126)

Sacramento, California, 95821, United States
Lexicon Investigational Site (128)

Anniston, Alabama, 36207, United States
Lexicon Investigational Site (129)

San Diego, California, 92103, United States
Lexicon Investigational Site (130)

Manassas, Virginia, 20110, United States
Lexicon Investigational Site (131)

Winter Haven, Florida, 33880, United States
Lexicon Investigational Site (132)

Flossmoor, Illinois, 60422, United States
Lexicon Investigational Site (133)

The Villages, Florida, 32159, United States
Lexicon Investigational Site (138)

The Villages, Florida, 32162, United States
Lexicon Investigational Site (139)

Olive Branch, Mississippi, 38654, United States
Lexicon Investigational Site (140)

New Bedford, Massachusetts, 02740, United States
Lexicon Investigational Site (142)

New York, New York, 100029, United States
Lexicon Investigational Site (144)

Orlando, Florida, 32806, United States
Lexicon Investigational Site (145)

Winston-Salem, North Carolina, 27103, United States
Lexicon Investigational Site (146)

Orlando, Florida, 32801, United States
Lexicon Investigational Site (148)

Norman, Oklahoma, 73069, United States
Lexicon Investigational Site (150)

Atlanta, Georgia, 30303, United States
Lexicon Investigational Site (151)

Marietta, Georgia, 30060, United States
Lexicon Investigational Site (152)

Houston, Texas, 77074, United States
Lexicon Investigational Site (153)

Euless, Texas, 76040, United States
Lexicon Investigational Site (154)

San Diego, California, 92120, United States
Lexicon Investigational Site (155)

Lewisville, Texas, 75057, United States
Lexicon Investigational Site (156)

St Louis, Missouri, 63110, United States
Lexicon Investigational Site (157)

Summerville, South Carolina, 29486, United States
Lexicon Investigational Site (158)

Dallas, Texas, 75231, United States
Lexicon Investigational Site (159)

San Antonio, Texas, 78233, United States
Lexicon Investigational Site (160)

Memphis, Tennessee, 38119, United States
Lexicon Investigational Site (161)

Fresno, California, 93710, United States
Lexicon Investigational Site (162)

Las Vegas, Nevada, 89123, United States
Lexicon Investigational Site (163)

Lomita, California, 90717, United States
Lexicon Investigational Site (164)

Miami, Florida, 33176, United States
Lexicon Investigational Site (165)

Norfolk, Virginia, 23510, United States
Lexicon Investigational Site (167)

Schenectady, New York, 12304, United States
Lexicon Investigational Site (168)

Dayton, Ohio, 45424, United States
Lexicon Investigational Site (169)

Long Beach, California, 90806, United States
Lexicon Investigational Site (170)

New Orleans, Louisiana, 70115, United States
Lexicon Investigational Site (171)

Walnut Creek, California, 94596, United States
Lexicon Investigational Site (172)

Chicago, Illinois, 60623, United States
Lexicon Investigational Site (173)

Canoga Park, California, 91303, United States
Lexicon Investigational Site (174)

Kansas City, Missouri, 64114, United States
Lexicon Investigational Site (177)

Daytona Beach, Florida, 32117, United States
Lexicon Investigational Site (178)

Newton, Kansas, 67114, United States
Lexicon Investigational Site (179)

Escondido, California, 92025, United States
Lexicon Investigational Site (180)

Hollywood, Florida, 33024, United States
Lexicon Investigational Site (181)

Walnut Creek, California, 94598, United States
Lexicon Investigational Site (182)

Plantation, Florida, 33317, United States
Lexicon Investigational Site (183)

Charleston, South Carolina, 29406, United States
Lexicon Investigational Site (184)

Springfield, Missouri, 65807, United States
Lexicon Investigational Site (185)

El Dorado, Kansas, 67042, United States
Lexicon Investigational Site (186)

Wichita, Kansas, 67207, United States
Lexicon Investigational Site (187)

Eugene, Oregon, 97404, United States
Lexicon Investigational Site (188)

Jacksonville, Florida, 32256, United States
Lexicon Investigational Site (189)

Daphne, Alabama, 36526, United States
Lexicon Investigational Site (190)

New Orleans, Louisiana, 70119, United States
Lexicon Investigational Site (191)

Inglewood, California, 90301, United States
Lexicon Investigational Site (192)

Austin, Texas, 78759, United States
Lexicon Investigational Site (193)

Dallas, Texas, 75230, United States
Lexicon Investigational Site (194)

Brandon, Florida, 33511, United States
Lexicon Investigational Site (195)

Phoenix, Arizona, 85028, United States
Lexicon Investigational Site (196)

Harlingen, Texas, 78550, United States
Lexicon Investigational Site (197)

Houston, Texas, 77065, United States
Lexicon Investigational Site (198)

Fleming Island, Florida, 32003, United States
Lexicon Investigational Site (199)

Baytown, Texas, 77521, United States
Lexicon Investigational Site (200)

Asheville, North Carolina, 28803, United States
Lexicon Investigational Site (201)

Columbia, South Carolina, 29205, United States
Lexicon Investigational Site (202)

Rock Hill, South Carolina, 29730, United States
Lexicon Investigational Site (203)

San Antonio, Texas, 78229, United States
Lexicon Investigational Site (204)

Huntington Beach, California, 92647, United States
Lexicon Investigational Site (205)

North Charleston, South Carolina, 29405, United States
Lexicon Investigational Site (206)

Scottsdale, Arizona, 85258, United States
Lexicon Investigational Site (209)

Greensboro, North Carolina, 27410, United States
Lexicon Investigational Site (210)

Oklahoma City, Oklahoma, 73102, United States
Lexicon Investigational Site (211)

Vista, California, 92081, United States
Lexicon Investigational Site (212)

Monroe, North Carolina, 28112, United States
Lexicon Investigational Site (213)

Owensboro, Kentucky, 42303, United States
Lexicon Investigational Site (214)

Katy, Texas, 77494, United States
Lexicon Investigational Site (215)

Guntersville, Alabama, 35976, United States
Lexicon Investigational Site (216)

Las Vegas, Nevada, 89106, United States
Lexicon Investigational Site (219)

Salt Lake City, Utah, 84107, United States
Lexicon Investigational Site (220)

Beavercreek, Ohio, 45432, United States
Lexicon Investigational Site (221)

San Antonio, Texas, 78240, United States
Lexicon Investigational Site (222)

Birmingham, Alabama, 35216, United States
Lexicon Investigational Site (223)

Mesquite, Texas, 75150, United States
Lexicon Investigational Site (224)

St. George, Utah, 84790, United States
Lexicon Investigational Site (225)

Waltham, Massachusetts, 02451, United States
Lexicon Investigational Site (227)

Rochester, New York, 14609, United States