Type 2 diabetes mellitus

This Phase 3 trial is testing whether a once-daily 50 mg semaglutide tablet can help East Asian adults with overweight or obesity lose weight. Participants will take either the active tablet or a placebo for 68 weeks, alongside lifestyle counseling on diet and physical activity. …

This study tests whether a new tablet formulation of semaglutide (oral semaglutide D) works as well as the approved version in Japanese adults with type 2 diabetes. About 264 participants will take either the new or approved tablet once daily for 27 weeks. Researchers will compar…

This study looked at whether aspirin or a diabetes drug called an SGLT2 inhibitor (like dapagliflozin) can improve liver health in people with type 2 diabetes and non-alcoholic fatty liver disease. Researchers measured liver enzymes, cholesterol, and liver stiffness (using FibroS…

This study will follow about 470 adults with type 2 diabetes who are starting oral semaglutide as part of their normal care. Researchers will track changes in blood sugar (HbA1c) and body weight over 5 to 7 months. The goal is to see how well the medication works when prescribed …

This study tested a new medicine called NNC0519-0130 in 299 adults with type 2 diabetes. The goal was to see if a once-weekly injection can lower blood sugar and body weight. Participants received up to 7 different doses for about 40 weeks. The results will help find the best dos…

This study tested a new medicine called NNC0487-0111 in 448 adults with type 2 diabetes. Participants received either a once-weekly injection, a daily pill, or a placebo for about 43 weeks. The goal was to see how well different doses lower blood sugar and body weight.

This phase 2 trial tests whether adding nicorandil, a drug typically used for heart conditions, can improve blood sugar control and reduce body weight in obese people with type 2 diabetes who are already taking sulfonylureas. About 46 adults with a BMI over 30 will receive nicora…

This trial tests an experimental oral drug called HTD1801 in adults with nonalcoholic steatohepatitis (NASH), a serious liver condition, along with liver fibrosis and type 2 diabetes or prediabetes. Participants receive either HTD1801 or a placebo to see if the drug can improve l…

This study tested a new insulin called icodec that is injected just once a week, compared to standard daily insulin shots, in over 1,000 adults with type 2 diabetes who had never used insulin before. The goal was to see if the weekly shot controls blood sugar just as well as dail…

This study tested a new insulin called icodec that is injected just once a week, compared to the standard daily insulin glargine, in 429 adults with type 2 diabetes. Participants received either the weekly or daily insulin for 6 months. The goal was to see if the weekly shot cont…

This trial tests whether inhaled insulin (Exubera) can control blood sugar as well as insulin glargine (Lantus) injections in adults with type 2 diabetes who are not well controlled on two or more oral medications. Participants will receive either inhaled insulin before meals or …

This Phase 3 trial tested whether HTD1801 (berberine ursodeoxycholate) can help people with type 2 diabetes who aren't well controlled on metformin alone. Over 500 participants received either the drug or a placebo for 24 weeks. The main goal was to see if the drug lowered blood …

This trial tests whether an inhaled form of insulin (Exubera) can control blood sugar as effectively as a daily insulin injection (Lantus) in adults with type 2 diabetes who are not well controlled on two or more oral medications. Participants are randomly assigned to add either …

This completed study compared the effectiveness of once-daily oral semaglutide (Rybelsus) to other oral diabetes medications in 1020 adults with type 2 diabetes who were already taking metformin. Participants were randomly assigned to receive either Rybelsus or another diabetes p…

This trial investigates whether a traditional herbal drug, NOSHIN SHAHD, can improve insulin resistance and reduce inflammation and oxidative stress in people with type 2 diabetes. Participants will take the herbal drug or a placebo for about six weeks, and researchers will measu…

This pilot study tests whether having older Black men with diabetes lead support groups can help other older Black men better manage their type 2 diabetes. All 48 participants receive standard diabetes education, and half also get 6 months of monthly peer-led support sessions. Th…

This study tests whether a peer-supported self-care program can improve quality of life and diabetes management in adults aged 60 and older with type 2 diabetes. Participants in the intervention group will join weekly video calls with trained peer supporters and receive support v…

This trial tests whether a 12-week calorie-restricted diet, combined with the weight-management drug Contrave, can help people with type 2 diabetes and obesity achieve remission. Remission means blood sugar levels drop below the diabetes threshold without needing glucose-lowering…

This study tests whether wearing a continuous glucose monitor (CGM) alongside lifestyle changes can improve insulin sensitivity in teens aged 10-17 with prediabetes. Fifteen overweight or obese participants will use the Dexcom G7 device to see real-time glucose data, aiming to bo…

This trial tests whether time-limited eating—consuming all food and drinks within an 8-hour period and fasting for the remaining 16 hours—can improve blood sugar control, insulin function, and body fat in adolescents with type 2 diabetes. Participants aged 12 to 21 will follow th…

This study tests a newly developed mobile app designed for adults with type 2 diabetes who are starting insulin for the first time. The app aims to improve how people perceive insulin use and how well they manage their own care. Over one month, participants will use the app and h…

This trial explores whether a gluten-free diet can ease digestive symptoms and improve blood sugar control in people with type 2 diabetes who have non-celiac gluten sensitivity. Participants first follow a gluten-free diet for six weeks. Those who feel better then take part in a …

This study tested a new medicine called survodutide (BI 456906) to see if it helps people with overweight or obesity and type 2 diabetes lose weight. Over 750 adults received either the drug or a placebo injection once a week for about 76 weeks, along with diet and exercise advic…

This early study tests a herbal effervescent tablet taken twice daily before meals in 14 adults with type 2 diabetes. The goal is to see if it safely helps lower blood sugar levels (HbA1c, fasting, and after meals). Participants include those managing diabetes with diet or supple…

This study tests whether three diabetes medications—liraglutide, empagliflozin, and linagliptin—can help reverse mild cognitive impairment (early memory and thinking problems) in people with type 2 diabetes. About 396 participants will take one of the drugs for 48 weeks, with an …

This study tests a new procedure called ReCET that uses gentle electrical pulses to regenerate the lining of the small intestine. Combined with a diabetes drug (semaglutide), the goal is to help people with type 2 diabetes stop using insulin. The study involves 32 adults and comp…

This trial asks whether cooking with refined high-oleic palm oil can improve cholesterol and blood sugar levels as effectively as olive oil. Healthy adults will be randomly assigned to use one of the two oils in their daily cooking for four months. Researchers will measure change…

This study looks at whether involving family members can help people with type 2 diabetes in rural Kentucky eat healthier and exercise more. Researchers will work with 75 participants and their families to create a personalized nutrition and physical activity plan for 6 months. T…

This trial tests whether a smart insulin pen called DIA:CONN P8 can help people with type 1, type 2, or pancreatogenic diabetes better control their blood sugar. Participants use the pen for 12 weeks, and the pen automatically calculates bolus insulin doses based on meal informat…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study tested a new drug called HTD1801 (berberine ursodeoxycholate) against the standard diabetes drug dapagliflozin in 367 adults with type 2 diabetes whose blood sugar was not well controlled by metformin alone. The main goal was to see how well HTD1801 lowers blood sugar …

This study looks at whether bariatric (weight-loss) surgery can reduce the risk of heart attacks, strokes, heart failure, and death in people who have both type 2 diabetes and obesity. It compares people who had the surgery with those who received usual diabetes care. The goal is…

This Phase 3 trial tested whether HTD1801, a new drug made from a modified natural compound, can lower blood sugar in people with type 2 diabetes who struggle to control it with diet and exercise alone. The study enrolled 408 adults and compared the drug to a placebo over 24 week…

This trial tests whether a smartphone app called Kiplin, which uses games, telecoaching, and social support, can increase daily physical activity in people with obesity or type 2 diabetes. It compares the app to a standard three-month face-to-face exercise program. The main goal …

This clinical trial is testing an investigational drug called HTD1801 (berberine ursodeoxycholate) to see if it can improve blood sugar control in adults with type 2 diabetes that is not well managed by diet and exercise alone. The study will compare the drug against a placebo ov…

This phase 3 trial compares an experimental once-weekly injection, HRS9531, to the established drug semaglutide in adults with type 2 diabetes that is not well controlled by metformin alone or with SGLT2 inhibitors. The study will measure changes in blood sugar levels and body we…

This Phase 3 trial tests retatrutide, a once-weekly injection, in 1000 adults with type 2 diabetes who are overweight or obese. The study also looks at a subset of participants with obstructive sleep apnea. Over 89 weeks, researchers will measure weight loss, changes in sleep apn…

This trial tests whether adding supervised exercise to standard care can improve wound healing in people with diabetic foot ulcers. Participants are randomly assigned to aerobic exercise, a structured exercise protocol, or standard care alone for 12 weeks. Researchers track ulcer…

This trial investigates whether a once-weekly injection of semaglutide can improve blood sugar control and reduce body weight in adults with type 2 diabetes and obesity who have not achieved adequate control with standard therapy. Participants receive semaglutide for 16 weeks, st…

This pilot trial tests whether a single infusion of pegloticase, a drug that breaks down uric acid, can improve markers of heart and kidney health in young men aged 18–25 with youth-onset type 2 diabetes. High uric acid is common in this group and linked to later complications. T…

This trial tests whether a mobile health system that sends real-time text messages—prompting users to take a walk or stand up after sitting too long—can increase physical activity in people with prediabetes or type 2 diabetes. Participants receive a Fitbit tracker and brief advic…

This study looks at whether offering financial rewards, along with nurse coaching and home monitoring, helps adults with type 2 diabetes improve their blood sugar control. About 450 participants will be randomly assigned to receive either nurse coaching and home monitoring alone,…

This trial tests whether adding lactulose—a type of sugar syrup—to the standard bowel-cleansing drink (PEG-ELS) can improve colonoscopy preparation in people with type 2 diabetes. Diabetic patients often have poor bowel cleansing, which can reduce the quality of the exam. The stu…

This study tested whether using a continuous glucose monitor (CGM) helps adults with type 2 diabetes control their blood sugar better than traditional finger-prick testing. About 600 participants from two community health centers in China wore a CGM device for three 2-week period…

This trial investigates whether drinking fig leaf tea twice a day for 8 weeks, along with a low-glycemic diet, can help protect kidney function in adults with type 2 diabetes and stage 2 chronic kidney disease. Researchers will measure changes in blood sugar, cholesterol, and kid…

This study looks at how well the diabetes drug empagliflozin (Jardiance) works in everyday medical practice, outside of a controlled research setting. Researchers are comparing it to other diabetes medicines in over 230,000 adults with type 2 diabetes. The goal is to see if the h…

This study investigates whether reducing iron levels in the body through blood donation can improve insulin sensitivity and liver function in people with type 2 diabetes and non-alcoholic fatty liver disease. Participants will undergo phlebotomy until their iron stores are deplet…

This study tests whether a connected smartphone app called Health2Sync helps adults with type 2 diabetes who use basal insulin achieve better blood sugar control. The app syncs blood glucose readings and shares them with doctors, who can then adjust insulin doses. Researchers com…

This study tests whether a structured Diabetes Healthcare Program can help adults with type 2 diabetes improve their blood sugar control and feel more confident managing their condition. Participants attend six biweekly training sessions covering diet, exercise, medication, and s…

This study investigates whether a 12-week program combining aerobic and resistance exercise can improve blood sugar control and cognitive function in adults aged 65-79 with type 2 diabetes and mild memory issues. Participants follow a supervised exercise routine that gradually in…

This study tests a support program for people with type 2 diabetes and chronic kidney failure who struggle to take their medications regularly. Participants receive an electronic pill bottle that tracks when they open it, plus short motivational interviews with a pharmacist. The …

This study tests an experimental oral drug called LY3502970 in Japanese adults with type 2 diabetes. The main goal is to check for side effects and see how the body processes the drug. Participants take either the drug or a placebo and are monitored over up to 24 weeks with blood…

This phase 3 trial tests whether an experimental injectable drug called HRS9531 can help adults with type 2 diabetes achieve better blood sugar control when diet and exercise alone are not enough. Participants receive either HRS9531 or a placebo for 36 weeks. The main goal is to …

This trial investigates a surgical procedure for people with type 2 diabetes and mild obesity (grade 1). The surgery combines three steps: rerouting part of the small intestine, reducing the stomach size, and cutting certain abdominal nerves. The goal is to see if this approach c…

This study investigates whether adding foxtail millet muffins to the diet can help manage blood sugar and improve metabolic health in obese adults with type 2 diabetes. Over 10 weeks, participants eat either a wheat muffin or one or two foxtail millet muffins daily, alongside a l…

This study investigates whether taking two medications—finerenone and empagliflozin—together can better slow kidney function decline in people with chronic kidney disease and type 2 diabetes compared to taking either drug alone. Participants are randomly assigned to receive the c…

This study tests whether a personalized nutrition program—where meals are tailored to each person's calorie needs based on age, sex, weight, height, and activity level—can improve blood sugar, weight, and blood pressure in adults with type 2 diabetes. Participants receive either …

This study tracks the long-term safety of dorzagliatin, a drug for type 2 diabetes, in over 2,000 patients over 52 weeks. Researchers monitor side effects and how well the drug controls blood sugar. The goal is to ensure the drug remains safe for everyday use.

This trial investigates whether a structured exercise program can improve fitness and lower risk factors for heart disease, stroke, and type 2 diabetes in Latina women who have had breast cancer. Participants are randomly assigned to either an 8-month progressive exercise program…

This study tests a fixed-dose combination of insulin glargine and lixisenatide (iGlarLixi) in 105 adults with type 2 diabetes whose blood sugar is not well controlled on oral drugs or other injectables. The main goal is to check safety and side effects, while also measuring chang…

This study tests a program called 'Disfrutando' designed to help people with type 2 diabetes, especially those in high-burden communities, better manage their condition. The program focuses on practical self-management skills and addressing social factors that make diabetes harde…

This study tests whether walking with a wearable hip exoskeleton can improve blood sugar control after meals in people with type 2 diabetes. Participants walk for 30 minutes after a meal, either without assistance or wearing the exoskeleton in two different support modes. The goa…

This large study looks at real-world data from 60,000 people with type 2 diabetes and obesity to compare four diabetes drugs—dulaglutide, semaglutide, tirzepatide, and sitagliptin—in preventing heart attacks, strokes, and death. Researchers are analyzing insurance claims to see w…

This trial compares a generic extended-release tablet containing empagliflozin and metformin to the brand-name Synjardy XR. Healthy adults aged 18 to 45 receive a single dose of each version in random order, and researchers measure drug levels in the blood to see if the generic w…

This study looks at health records of 120,000 people with type 2 diabetes and overweight to compare two injectable drugs: semaglutide and dulaglutide. Researchers want to see which one better reduces the risk of death, heart attack, or stroke. The goal is to understand how these …

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This completed trial tested whether laser acupuncture could improve body shape index (ABSI) in 50 women aged 40-50 with uncontrolled type 2 diabetes and obesity. Participants received either real or sham laser acupuncture twice a week for 12 weeks, plus a low-glycemic diet. The s…

This large phase 3 trial compares two injectable diabetes medications, tirzepatide and dulaglutide, to see which one better prevents major heart problems like heart attacks, strokes, or death from cardiovascular causes. The study includes over 13,000 adults aged 40 and older with…

This trial compares a generic extended-release tablet containing three diabetes drugs (empagliflozin, linagliptin, and metformin) to the brand-name Trijardy XR. The study involves 36 healthy adults who take a single dose of each version under fed conditions to see if the generic …

This trial investigates whether a generic tablet containing imeglimin hydrochloride works the same way in the body as the brand-name diabetes drug Twymeeg. Healthy adults aged 18 to 45 take a single dose of each version under fasting conditions, and researchers compare how much d…

This study investigates whether giving endocrinologists (diabetes specialists) a one-week intensive training program helps them manage type 2 diabetes more effectively. The training includes a hospital stay experience and hands-on patient management. Researchers will compare bloo…

This study tests whether combining two diabetes drugs—semaglutide and empagliflozin—can reverse liver damage from NASH (a severe form of fatty liver disease) in people with type 2 diabetes. Participants will receive either the combo, empagliflozin alone, or a placebo for 48 weeks…

This study tests an experimental drug, JP-2266, in adults with type 2 diabetes. The drug works by blocking two proteins (SGLT1 and SGLT2) to help lower blood sugar. Participants receive either JP-2266 or a placebo for 12 weeks, and researchers measure changes in HbA1c, a key bloo…

This study tests PS1, a new tablet designed to help control blood sugar in people with type 2 diabetes. It is the first time PS1 is given to humans, so the main goal is to check its safety and how the body handles it. The trial includes healthy volunteers and people with type 2 d…

This study investigates whether 12 weeks of moderate aerobic exercise can improve heart health, metabolism, and menopause symptoms in postmenopausal women who have two or more chronic conditions like high blood pressure and high cholesterol. Participants will exercise three times…

This study investigates whether a passive stretching program can reduce muscle and tendon stiffness in people with type 2 diabetes. Diabetes can cause muscles and tendons to become stiffer, making walking harder and increasing energy use. The trial compares stiffness in people wi…

This study tests whether an extract from the earthworm Lumbricus rubellus (DLBS1033) can reduce inflammation and improve quality of life in people with type 2 diabetes. Sixty adults on standard diabetes therapy will receive either a low or high dose of the extract or continue sta…

This study tests the long-term safety of an experimental oral drug called orforglipron in adults with type 2 diabetes whose blood sugar is not well controlled by diet, exercise, or other diabetes pills. Participants take the drug once daily for about a year, and researchers monit…

This study compares a new drug, HRS-7535, to an existing diabetes medication, dapagliflozin, in adults with type 2 diabetes whose blood sugar is not well controlled with metformin alone. The goal is to see if HRS-7535 works better at lowering blood sugar and body weight over 32 w…

This pilot study tests whether dialectical behavioural therapy (DBT) — a type of talk therapy that teaches skills like mindfulness and emotion regulation — can help Indigenous youth with type 2 diabetes improve their quality of life and diabetes control. The study enrolls 20 yout…

This trial investigates whether changing how often and when people with type 2 diabetes eat can improve weight, blood sugar, and cholesterol. Over 12 weeks, participants follow one of three eating plans: a standard 6-meal diet, a 3-meal diet, or time-restricted eating (eating all…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tests a 6-week online group program designed to help African American women with type 2 diabetes reduce diabetes-related distress and improve blood sugar control. The program combines diabetes education, motivational interviewing, and cognitive behavioral therapy, deli…

This completed study tested whether a customizable texting program could help veterans with type 2 diabetes improve their blood sugar control. 366 veterans were randomly assigned to receive either standard daily diabetes texts or a more interactive version with check-ins, medicat…

This study tested a 12-week program where nurses provided diabetes education and support through video calls to 128 adults with type 2 diabetes in Thailand. Participants had uncontrolled diabetes and owned a smartphone. The program included an initial in-person session followed b…

This study tested a 6-week diabetes self-management program for ethnic minority elderly (aged 60+) in rural Thailand. The program included weekly group sessions on diet, exercise, medication, and emotional coping, plus two home visits. Researchers measured changes in blood sugar …

This study tests whether an artificial intelligence system can safely and effectively adjust insulin doses for people with type 2 diabetes while they are in the hospital. About 144 participants will be randomly assigned to have their insulin doses set either by the AI system or b…

This study tested whether giving extra support to Black adults who don't lose weight early in a diabetes prevention program helps them lose more weight. Over 400 participants joined a 12-week program at churches or community centers. Those not losing weight early got extra phone …

This study tested an electronic glucose management system (eGMS) designed to help doctors decide insulin doses for hospitalized patients with type 2 diabetes. The trial compared the eGMS to the usual insulin ordering protocol in 140 patients. The goal was to see if the eGMS could…

This study looked at whether delivering healthy food to the homes of rural adults with type 2 diabetes and food insecurity could improve their blood sugar control and diet. Over 400 participants either received standard care alone or standard care plus free healthy food deliverie…

This trial tests whether a family-centered diabetes education program helps people with type 2 diabetes manage their blood sugar better than standard education. About 1,100 adults with type 2 diabetes and their family members take part. Participants are randomly assigned to eithe…

This study tested whether a team of specialists—an endocrinologist, diabetes educator, and dietician—could help people with type 2 diabetes and heart disease control their blood sugar better than standard care. 169 patients were split into two groups: one received usual care from…

This study tested whether adding mindful eating training to a low-carb diet education helps people with type 2 diabetes follow the diet better. About 125 adults were randomly assigned to get either diet education alone or diet education plus mindful eating sessions. The main goal…

This study tested whether a smartphone app that lets people log their blood sugar readings at home can improve diabetes control. One hundred adults with poorly controlled type 2 diabetes used the app or continued usual care for 3 months. Researchers measured changes in HbA1c, a k…

This completed study tested whether resveratrol, a natural compound found in grapes and berries, can improve blood vessel health and blood sugar control in people with type 2 diabetes. 48 adults took either a resveratrol pill or a placebo daily for 12 weeks. Researchers measured …

This study tested a culturally tailored program called Together Overcoming Diabetes (TOD) for American Indian families in Ojibwe communities. Adult caregivers with type 2 diabetes and their youth (ages 10-16) worked with local health coaches to set health goals. The program inclu…

This pilot study tested whether a combination of phentermine and topiramate, two drugs used for weight loss, could help shrink uric acid kidney stones in obese people with type 2 diabetes or pre-diabetes. Nineteen participants were randomly assigned to receive the drug combo or c…

This study tested whether making U.S. dietary guidelines more culturally relevant for African Americans could improve diet quality and reduce type 2 diabetes risk. 63 overweight or obese African American adults with at least three diabetes risk factors attended weekly classes for…

This study tested a new insulin called icodec, taken just once a week, against a standard daily insulin (degludec) in 588 adults with type 2 diabetes who had never used insulin before. Participants received either weekly icodec plus a daily placebo, or daily degludec plus a weekl…

This study tested a new once-a-week injection called IcoSema, which combines insulin and semaglutide, against semaglutide alone in 683 adults with type 2 diabetes. The goal was to see if IcoSema improves blood sugar levels more effectively. Participants received weekly shots for …

This study tested whether dapagliflozin, a drug used for type 2 diabetes, can lower blood pressure in people who have received a kidney transplant. Fifty-two participants took either the drug or a placebo for 12 weeks. The goal was to see if the drug helps control blood pressure …

This study looked at how safe a new once-weekly insulin (insulin icodec) is during exercise and long periods without food in 30 adults with type 2 diabetes. Participants first took a daily insulin for a week, then switched to the weekly insulin for up to 14 weeks. The goal was to…

This early study tested a single injection of a new drug called ENT-03S in 49 people who were either obese but otherwise healthy, or had both obesity and type 2 diabetes. The main goal was to check safety and how the drug moves through the body. Participants were randomly assigne…

This completed Phase 3 study tested whether adding semaglutide to a new once-weekly insulin (insulin icodec) improves blood sugar control in 148 adults with type 2 diabetes. Participants first received insulin icodec alone for 26 weeks; those with still-high blood sugar then adde…

This study tested three different diet plans in 108 overweight adults with type 2 diabetes to see which best improves blood sugar control. Participants followed either standard nutrition advice, a structured meal plan with special diabetes drinks, or that same structured plan plu…

This study looked at whether eating more dairy products (full-fat or low-fat) helps people with type 2 diabetes manage their blood sugar, weight, and heart health. 112 adults with type 2 diabetes who ate fewer than 3 servings of dairy per day were assigned to add either full-fat …

This study looked at whether a dietary fiber called OptiFibre can help people with type 2 diabetes control their blood sugar and lose weight. About 80 adults with diabetes were observed for 3 months. The goal was to see if adding this fiber to their routine improved blood sugar l…

This early-stage study tested an oral drug called LY3502970 in 68 adults with type 2 diabetes. The main goal was to check safety and side effects, while also measuring how the drug moves through the body and affects blood sugar. Participants took the drug or a placebo for up to 1…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This study looked at whether gastric bypass surgery or the best medical care is more effective for obese people with poorly controlled type 2 diabetes. Researchers tracked 66 participants to compare death rates, weight loss, blood sugar control, quality of life, and costs. The go…

This completed phase 3 trial tested three doses of the oral drug HRS-7535 against a placebo in 284 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The main goal was to see if HRS-7535 could lower HbA1c (a measure of average blood …

This study tested whether using activity trackers, text reminders, and short exercise videos could help people with type 2 diabetes reduce the time they spend sitting at work. Forty-six adults with type 2 diabetes who had mostly desk jobs took part. The goal was to see if these m…

This study tested whether applying a probiotic (Lactobacillus reuteri) directly into gum pockets, alongside standard deep cleaning, improves gum health in people with type 2 diabetes. Fourteen adults with moderate to severe gum disease and controlled diabetes took part. Each pers…

This study tested whether a daily postbiotic capsule (a substance that helps good gut bacteria) could improve blood sugar control in adults with type 2 diabetes. 106 participants took either the postbiotic or a placebo for 12 weeks. Researchers also analyzed genetics and gut bact…

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with overweight or obesity lose weight. About 242 people took part, comparing the drug to a placebo over roughly one year. The main goal was to see how much weight they lost and how many lost at least 5% …

This study looked at whether a daily prebiotic supplement (Molkosan®) could improve blood sugar and other health markers in people with type 2 diabetes. Twelve adults took a low dose (20 ml per day) for 12 weeks. Researchers measured changes in glucose tolerance, insulin levels, …

This study looked at whether giving underserved patients with type 2 diabetes a continuous glucose monitor (CGM) plus monthly telehealth visits with a pharmacist helps them manage their blood sugar better. 46 adults with uncontrolled diabetes took part. Researchers compared those…

This study tested whether a short period of intensive insulin therapy, followed by a combination of basal insulin, metformin, and vildagliptin, could help people with poorly controlled type 2 diabetes simplify their long-term treatment. The goal was to see if more participants co…

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study tested a smartphone app called T2.coach that tracks diet, blood sugar, activity, and sleep, then uses machine learning to give personalized behavioral goals. About 280 adults with type 2 diabetes and high blood sugar used the app for 6 months alongside standard diabete…

This study looked at whether three different low-calorie diets could improve blood sugar and body composition in 120 shift workers who are overweight and have prediabetes or type 2 diabetes. Each diet had a different amount and timing of protein. The goal was to see which approac…

This study tested a phone-based program for 100 African Americans aged 50+ with poorly controlled type 2 diabetes. The program combined diabetes education and help with social needs like food or housing. Results aim to show if this approach improves blood sugar control and qualit…

This completed study tested whether lotus seed capsules could improve nerve health, blood sugar, and immune function in 60 people with type 2 diabetes and nerve damage. Participants took either lotus seed or placebo capsules for 9 months alongside their regular diabetes treatment…

This study looked at how the diabetes drugs glyburide and metformin work in pregnant women with gestational diabetes. 177 women between 20 and 32 weeks pregnant took part. The goal was to find the right dose and understand how these drugs control blood sugar and improve insulin f…

This study tested whether GLP-1 receptor agonists, a type of diabetes drug, can improve heart function and reduce fat around the heart in 44 obese adults with type 2 diabetes. Participants received the drug BYETTA along with metformin. Researchers used MRI scans to measure heart …

This study tested whether taking a probiotic called Hafnia alvei HA4597 can help people lose more weight and control blood sugar better after gastric bypass surgery. 49 adults with obesity and type 2 diabetes took either the probiotic or a placebo twice a day for 90 days, startin…

This study tested a visual injection site map to help people with diabetes rotate where they inject insulin. The goal was to reduce lipohypertrophy—lumpy fatty tissue caused by repeated shots in the same spot—and improve blood sugar control. 170 adults on insulin for at least six…

This pilot study tested a mobile app and wearable devices to give personalized diet and activity advice to 27 adults with type 2 diabetes or prediabetes. The goal was to see if the app could help them improve their blood sugar levels and make healthier food choices. The study als…

This study looked at whether dapagliflozin, a diabetes medication, can improve how the heart uses sugar and blood flow in people with type 2 diabetes and stable coronary artery disease. 25 adults took either the drug or a placebo for 4 weeks. The goal was to see if the drug helps…

This study looked at how well adults with obesity or complicated overweight could stick to different very low-calorie ketogenic diets (VLCKD) in a real-world clinic. Participants chose one of four diet plans, ranging from all-natural foods to all meal replacements, and followed a…

This study tested whether a dietary supplement called phosphatidylserine can improve blood flow in people with type 2 diabetes. 36 adults took either the supplement or a placebo for 4 weeks. Researchers measured blood flow in the leg and arm to see if the supplement helped blood …

This study tested whether helping people with type 2 diabetes address unmet basic needs—like food, housing, and safety—can improve their blood sugar control. About 473 adults on Medicaid received either a 6-month navigation program or usual care. The goal was to see if this suppo…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested a new insulin (22011) to see if it works as well as an existing insulin (Ryzodeg) for people with type 2 diabetes. About 414 adults in China took part. The goal was to compare blood sugar control and safety. Results suggest the new insulin is a similar option fo…

This study looked at whether keeping blood sugar very low (under 130 mg/dL) is better than standard control (130-180 mg/dL) for non-critically ill patients with diabetes in the hospital. Researchers tracked 600 patients for complications like death, severe low blood sugar, infect…

This early study tested a single dose of the drug rongliflozin in 32 Chinese adults with type 2 diabetes who had normal, mildly, or moderately reduced kidney function. Researchers measured how the drug moved through the body and how it affected blood sugar and urine glucose. The …

This pilot study tested a 12-week phone program for 60 African American women aged 40-64 with type 2 diabetes and multiple caregiving responsibilities. Half received extra support for their caregiving stress plus diabetes education, while the other half got standard diabetes educ…

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study looked at whether a 12-week intensive lifestyle program focused on weight loss and diabetes control could improve diabetic peripheral neuropathy, a common nerve complication. Fifty adults with diabetes and a BMI between 30 and 45 took part. The program included diet, e…

This study tested whether eating more protein (1.5 grams per kilogram of body weight daily, instead of the usual 0.8 grams) could help older adults with type 2 diabetes prevent muscle loss and improve muscle function. Twenty-five participants followed either a high-protein or sta…

This study tested whether empagliflozin, a diabetes medication, lowers blood pressure more than other diabetes pills in adults with type 2 diabetes and high blood pressure. 300 participants took either empagliflozin or another diabetes drug for 12 weeks. Researchers measured bloo…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested a once-daily pill called orforglipron in 559 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The pill was compared to a placebo (a dummy pill) over about 54 weeks to see if it safely lowers blood sugar levels. Th…

This study looked at whether a 3-month supervised exercise program can improve blood sugar, body fat, and fitness in sedentary men aged 35-65 with type 2 diabetes, prediabetes, or overweight. Participants exercised at a fitness center under supervision. The goal was to see how di…

This study tested a program designed to help women with type 2 diabetes become more physically active. 86 women aged 30-65 took part. The program included a video, a pamphlet, and regular check-ins to encourage exercise. The goal was to see if this approach could increase daily a…

This study tested three different diabetes treatments in 186 overweight or obese adults newly diagnosed with type 2 diabetes. Participants received either empagliflozin plus metformin, sitagliptin plus metformin, or metformin alone for 12 weeks. Researchers measured changes in bl…

This completed trial tested whether providing free, healthy food boxes every two weeks for six months could improve blood sugar control and health behaviors in adults with type 2 diabetes living in a low-income community. 405 participants were randomly assigned to receive the foo…

This study tested the safety and effectiveness of the MiniMed 780G automated insulin pump in 574 adults with type 2 diabetes who need insulin. Participants used the system at home for about 135 days. The goal was to see if the pump improved blood sugar control without causing saf…

This study screened 316 people with type 2 diabetes who were at high risk for heart disease. Researchers tested whether adding the drug liraglutide to standard care could reduce new heart problems like heart attacks, strokes, and hospitalizations. The goal was to see if this appr…

This study tested whether a six-week empowerment-based health education program could improve self-management in 50 adults with type 2 diabetes. Participants learned about diabetes, diet, and physical activity through group activities and discussions. The goal was to see if this …

This study looked at how safe and effective Fiasp, a faster-acting mealtime insulin, is for people with type 1 or type 2 diabetes in everyday life. 42 adults used Fiasp as prescribed by their doctor for about 6 months. Researchers tracked side effects and blood sugar control to s…

This study tested whether using a continuous glucose monitor (CGM) in the hospital right after childbirth could better detect low blood sugar (hypoglycemia) in women with type 1 or type 2 diabetes, compared to standard finger-stick tests. Thirty-nine women in their third trimeste…

This study tested whether extra support from a pharmacist can help people with type 2 diabetes manage their blood sugar better. 122 participants were split into two groups: one got usual care, the other got usual care plus regular pharmacist sessions covering medication use, heal…

This study looked at how sitagliptin (Januvia) affects levels of anti-rejection drugs and blood sugar in 16 people who had a kidney transplant and have type 2 diabetes. Participants took sitagliptin daily for 3 months. The goal was to see if it is safe and works well in this grou…

This study tested whether a nurse-led mobile app could improve diabetes management in 112 adults with type 2 diabetes. The intervention group received structured education and reminders via the app for 6 months, while the control group got standard care. The main goal was to see …

This study looked at whether a class of diabetes drugs called SGLT2 inhibitors can improve fatty liver disease in people with type 2 diabetes. 150 adults took the drugs for 6 months, and researchers measured changes in liver stiffness, fat levels, and blood sugar control. The goa…

This Phase 3 trial tested a new weekly injection called TG103, combined with the common diabetes pill metformin, in 632 adults with type 2 diabetes. The goal was to see if TG103 could lower blood sugar better than an existing weekly shot (dulaglutide) over 28 weeks. Participants …

This completed study tested whether a high-intensity medical weight loss program, supported by a digital platform and continuous glucose monitors, could help people with type 2 diabetes lose weight and achieve remission. 64 participants were enrolled and compared to a group recei…

This study tested whether a diet rich in slowly digestible starch (SDS) could improve blood sugar control and reduce inflammation in people with type 2 diabetes. Fifty-three adults with type 2 diabetes followed either a high-SDS or low-SDS diet for three months. Researchers measu…

This study tested whether wearing a continuous glucose monitor (CGM) and watching AI-generated health education videos could help 30 adults with prediabetes control their blood sugar. Participants wore a CGM that tracked glucose levels without showing them the readings during the…

This study tested whether using a continuous glucose monitor (CGM) instead of standard fingerstick testing helps people with type 2 diabetes heal foot ulcers faster. 116 adults who had been hospitalized for a diabetic foot ulcer were randomly assigned to use either a CGM or their…

This study tested a new weekly injection called TG103 in 465 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. Participants received either a low dose, a higher dose, or a placebo for several weeks. The main goal was to see if TG103…

This study tested whether taking low-dose aspirin (150 mg) daily, starting in the first trimester, could reduce pregnancy complications in women with type 1 or type 2 diabetes. The trial included 137 women and looked at outcomes like preeclampsia, early preterm birth, low birth w…

This small safety study tested a new artificial intelligence system called FUSION that automatically controls blood sugar levels in people with type 2 diabetes. Three participants who use insulin at home had their glucose managed by the device for 24 hours while eating standard m…

This study tested whether intensive, personalized nutrition therapy can help adults with type 2 diabetes better control their blood sugar, reduce inflammation, and improve gut health. Forty adults were split into two groups: one received weekly one-on-one nutrition counseling for…

This study tested a telenursing program that gave health education and lifestyle advice to 70 adults with type 2 diabetes in Bangladesh. Participants used their smartphones to get support from nurses on diet, exercise, and medication. The goal was to see if this approach could im…

This study compared two exercise programs—periodized circuit training and conventional strength training—in 50 adults with type 2 diabetes. Over 6 weeks, researchers measured changes in heart and lung fitness, quality of life, and blood sugar control. The goal was to see which ap…

This pilot study tested a web-based version of the DECIDE program, called eDECIDE, which teaches problem-solving skills to help African Americans manage type 2 diabetes. The study involved 36 participants and compared the online program to the traditional in-person group sessions…

This study tested whether adding pioglitazone or dapagliflozin to standard diabetes pills (alogliptin and metformin) helps control blood sugar better in adults with type 2 diabetes. A total of 133 participants took one of the two extra drugs for 26 weeks. The main goal was to see…

This completed study looked at how two common diabetes drugs, dapagliflozin and empagliflozin, affect weight, cholesterol, and inflammation in 260 obese adults newly diagnosed with type 2 diabetes. Over six months, researchers measured changes in body weight, blood fats, and mark…

This study tested a virtual culinary medicine program for 89 adults with type 2 diabetes and elevated body mass index. Participants attended five online cooking and nutrition sessions, learning basic skills and healthy eating habits. Researchers measured changes in blood sugar (H…

This study tested a personalized dietary program for 30 adults with type 2 diabetes. The program was designed to help participants better manage their blood sugar and potentially achieve remission. Researchers measured changes in HbA1c and other health markers to see if the diet …

This study tested an experimental cell therapy called REACT (rilparencel) in 53 adults with type 1 or 2 diabetes and chronic kidney disease. The therapy involves injecting a person's own kidney cells into their kidneys to see if it can slow the loss of kidney function. The goal i…

This completed observational study looked at over 2,000 adults with type 2 diabetes who were already taking metformin plus another diabetes drug. Researchers wanted to see if adding a new combination pill called Zemidapa (which contains two diabetes medicines) could improve blood…

This study looked at whether giving vitamin D supplements to adults with type 2 diabetes who also have low vitamin D levels can improve their blood sugar control. 119 participants took a high dose of vitamin D once a month for three months. Researchers measured blood sugar and ot…

This study tested whether a daily supplement of overripe banana powder can improve blood sugar control in adults with type 2 diabetes. Sixty participants took either the banana supplement or a standard formula for 12 weeks. Researchers measured changes in fasting blood sugar, HbA…

This study tested whether eating tuna-based nuggets for three months could improve health in 120 people with heart disease and related conditions like obesity and diabetes. The nuggets were given as a source of selenium. Results showed improvements in some markers of inflammation…

This study looked at whether using a mobile app called Undermyfork along with a continuous glucose monitor (Dexcom G7) helps people with type 2 diabetes control their blood sugar better than standard care. About 91 adults with type 2 diabetes who were not on rapid-acting insulin …

This study tested whether a program that combines technology (like a monitoring system) with diabetes education and skills training can help African American adults with poorly controlled type 2 diabetes. About 200 participants used the system for 12 months, and researchers measu…

This study looked at whether a special dietary supplement could help heal foot ulcers in people with diabetes and prevent the need for amputation. 35 adults with diabetes and foot ulcers were observed for 6 weeks while using the supplement at home. The main goals were to see how …

This study tested a culturally adapted diabetes self-management program for Filipino-Americans with type 2 diabetes. The program combined group classes taught in Tagalog with text message support. Researchers measured changes in diabetes knowledge, self-confidence, and blood suga…

This study tested a new weekly medicine called retatrutide in 537 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. Participants received either the medicine or a placebo for about 11 months. The goal was to see if retatrutide safel…

This pilot study tested a new computer algorithm that uses continuous glucose monitor (CGM) readings to automatically suggest the right dose of long-acting insulin for people with type 2 diabetes. Thirty adults already using basal insulin were followed for 18 weeks to see if the …

This study compared two common diabetes drugs—dapagliflozin and metformin—in over 2,000 people with early type 2 diabetes (diagnosed less than 4 years). The goal was to see which drug better prevents serious complications like death, heart attack, stroke, heart failure, kidney di…

This study looked at 100 liver transplant patients with diabetes to see if dapagliflozin or sitagliptin is better at reducing liver fat and improving body composition. Participants took one of the two drugs for 12 months. The goal was to find a safer and more effective way to man…

This study tested a web-based app called Mobile Diabetes Detective (MoDD) in 248 adults with type 2 diabetes. The app helps users identify problems with blood sugar control and suggests better behaviors. Researchers measured changes in blood sugar (HbA1c), problem-solving skills,…

This study tested whether a longer intestinal bypass during stomach cancer surgery improves diabetes control better than the standard method. It included 94 adults with early-stage gastric cancer and type 2 diabetes. Researchers measured blood sugar and hormone levels one year af…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This study looked at whether weight-loss surgery (sleeve gastrectomy) is better than diet and medication for adults aged 65 and older with severe obesity and related health problems like type 2 diabetes, high blood pressure, sleep apnea, and knee arthritis. Sixty patients chose e…

This study tested a home-based behavioral program called Home DM-BAT for low-income seniors with type 2 diabetes. Two hundred Black or Hispanic seniors aged 65 and older took part. The program involved 8 weekly in-home sessions and monthly booster calls to help improve blood suga…

This study tested whether the drug dapagliflozin (Forxiga) works better than standard treatments for people with type 2 diabetes whose blood sugar is not well controlled on metformin alone. Over 600 adults took either dapagliflozin plus metformin or usual care (like sulfonylureas…

This study tested whether a once-weekly injection of exenatide (a diabetes drug) can protect the heart and kidneys in 57 adults with type 2 diabetes and mild kidney problems. Participants received either exenatide or a placebo for 38 weeks. Researchers measured blood and urine ma…

This study tested a 12-week intensive exercise program (aerobic and resistance training) in 58 adults aged 40-85 with type 2 diabetes and mild cognitive issues. The goal was to see if exercise could improve thinking, blood sugar, inflammation, and physical function. Results may h…

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This study tested an automated insulin delivery system (a smart pump) in 15 adults with type 1 or type 2 diabetes who also had advanced kidney disease or were on dialysis. Participants used the system for 8 weeks, then switched to their usual care for another 8 weeks. The goal wa…

This study tested a new insulin patch pump in 161 adults with type 1 or type 2 diabetes who needed intensive insulin therapy. Participants used either the new patch pump or a standard pump for 7 days in a hospital. Researchers measured changes in average blood sugar levels to see…

This study tested a special diabetes clinic within a primary care setting for patients with poorly controlled type 2 diabetes. The clinic brought together doctors, diabetes educators, nurses, behavioral health providers, and social workers to offer comprehensive care, including c…

This study compared several common diabetes medications when added to metformin in 7,850 adults with type 2 diabetes. The goal was to see which combination best kept blood sugar under control over time. Results help doctors and patients choose the most effective treatment plan.

This study tested whether a 12-week Ayurveda-inspired program combining a special diet, yoga, and breathing exercises was practical for adults with type 2 diabetes. Seventeen people started, and twelve completed the program. Participants followed the plan at least five days a wee…

This pilot study tested whether using smart insulin pens together with continuous glucose monitors (CGMs) can improve blood sugar control in adults with type 2 diabetes. Thirty participants used these devices to track their glucose levels and insulin doses. The goal was to see if…

This study tested a new daily injection called CT-868 in 103 overweight or obese adults with type 2 diabetes. Participants received either the drug or a placebo for 26 weeks. The main goal was to see if CT-868 could lower blood sugar levels (HbA1c) and help with weight loss.

This completed phase 4 trial compared two common diabetes drugs, dapagliflozin and empagliflozin, added to metformin in 108 adults with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Participants took one of the two drugs daily for six months. Researchers used live…

This study looked at whether giving adults with type 2 diabetes special education classes and follow-up phone calls helps them take better care of themselves, stick to their treatment, and feel more confident about their medications. 70 adults were split into two groups: one got …

This completed study looked at over 28,000 people with type 2 diabetes and a type of heart failure called HFpEF. Researchers compared two drugs, tirzepatide and semaglutide, to see which one better reduces the risk of death or hospitalization for heart failure. The study used rea…

This study tested a small, wearable sensor that sits just under the skin and measures blood sugar continuously for up to 5 days in adults with diabetes. 247 participants wore the sensor along with a standard monitor and took fingerstick tests to compare accuracy. The goal was to …

This study tested whether a new map for insulin injection sites (either digital or paper) could reduce skin lumps caused by insulin. 170 adults with diabetes who had been using insulin for at least six months took part. The map helped people rotate injection spots, aiming to impr…

This completed study tested whether a health behavior program designed with input from immigrant communities can improve diabetes management in first-generation immigrants with type 2 diabetes. Researchers compared the culture-sensitive program to standard care in 202 participant…

This Phase 3 trial tested whether a new injectable drug, HR17031, works better than standard insulin glargine for controlling blood sugar in Chinese adults with type 2 diabetes. The study included 401 people whose diabetes was not well controlled with oral medications. Researcher…

This study looked at whether a common diabetes medication (SGLT-2 inhibitor) can help people with type 2 diabetes lose weight. 360 participants took the pill daily for 3 months, and researchers measured changes in body mass index (BMI). The goal was to see if the drug could help …

This study tested a new medicine called CagriSema (a mix of two drugs) in 331 East Asian adults with obesity or overweight. Participants received a weekly injection for about 1.5 years. The main goal was to see how much weight they lost compared to another drug. The study is comp…

This study tested the safety and effectiveness of the Omnipod 5 SmartAdjust 2.0 system, an automated insulin pump, in 48 people aged 2 to 70 with type 1 or type 2 diabetes. The system uses a continuous glucose monitor to automatically adjust insulin delivery. The main goals were …

This study tested a new device, DyaMX, that uses an endoscope to regenerate the lining of the upper small intestine in people with type 2 diabetes. The goal was to see if the procedure is safe and can help improve blood sugar control. 65 adults with diabetes took part. The main f…

This study tested whether a daily semaglutide tablet helps Chinese adults with overweight or obesity lose weight. About 200 participants took either the drug or a placebo for 44 weeks, along with guidance on diet and exercise. The main goals were to measure the percentage of weig…

This 16-week study tested whether a low-fat vegan diet can improve insulin sensitivity and blood sugar control in people with type 2 diabetes. Twenty-six adults with type 2 diabetes and a BMI between 26 and 40 participated. They received weekly nutrition classes and one-on-one di…

This phase 2 study tested three different doses of a new injectable drug called maridebart cafraglutide (AMG 133) against a placebo in 592 adults who were overweight or obese, some with type 2 diabetes. The main goal was to see how much weight participants lost over 52 weeks. The…

This study tested whether weekly home delivery of diabetes-friendly food boxes, along with easy-to-understand diabetes education materials, could improve health in 101 low-income adults with type 2 diabetes who also faced food insecurity. Participants received the food boxes and …

This early-phase trial tested the safety and tolerability of a new drug called ZT002 in 32 healthy volunteers. Participants received either a single or multiple doses of ZT002 or a placebo by injection. The study aims to see if the drug is safe enough to move into larger trials f…

This study tested whether adding social gaming (earning points and supporting each other) to a weight loss app helps adults with overweight or obesity and at least 3 risk factors for type 2 diabetes lose more weight over 12 months. About 240 adults used a mobile app to track food…

This early-phase study tested a special form of cannabidiol (CBD) called DehydraTECH, alone or combined with GLP-1 drugs (like Ozempic), in 148 overweight or obese adults with prediabetes or type 2 diabetes. The main goal was to check safety and how the body processes the drugs, …

This Phase 3 trial tested a new drug called HR17031 against the standard insulin glargine in 393 adults with type 2 diabetes whose blood sugar was not well controlled despite using basal insulin and metformin. The study measured changes in HbA1c (average blood sugar), weight, and…

This study investigates whether hearing problems are an under-recognized complication of diabetes. Researchers will screen 172 adults with type 1 or type 2 diabetes using hearing tests and a questionnaire. If a hearing issue is found, a more detailed assessment will be done to de…

This study uses machine learning to tell apart diabetic kidney disease from other kidney diseases in people with type 2 diabetes. Researchers analyzed data from over 2,200 patients across 14 medical centers to build a model that uses routine clinical and lab information. The goal…

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study tested a new device called LabPatch, a small patch worn on the arm that measures blood sugar levels continuously. Researchers compared its accuracy to standard lab tests and two commercial glucose meters. The study involved 30 adults with type 1 or type 2 diabetes to s…

This study tested whether computer analysis of voice recordings can detect type 2 diabetes. Over 7,000 adults in the UK recorded themselves reading and answering questions online. A subset also provided blood samples to check accuracy. The goal is to see if voice biomarkers could…

This study looked at new markers in blood and urine to detect and predict the severity of drug-associated acute pancreatitis in adults. Researchers compared these markers in 175 patients with drug-induced pancreatitis, other pancreatic diseases, and healthy volunteers. The goal i…

This study tested a new device called the Cmate blood glucose analyzer, which measures blood sugar without needing a finger prick. Researchers compared its readings to standard blood tests in 40 healthy, pre-diabetic, and diabetic adults. The goal is to see if this non-invasive m…

This study tests whether screening women for type 2 diabetes while they are still in the hospital after giving birth can help catch the disease early and prevent it. About 116 women who had gestational diabetes will be randomly assigned to either early testing or usual care. The …

This study tested a program to prevent type 2 diabetes in Chinese immigrants with prediabetes. Participants received weekly videos on diabetes prevention and fresh, culturally appropriate produce. The goal was to see if this approach could help people lose weight and build health…

This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and ca…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study looked at two different exercise programs in 24 adults with prediabetes (higher than normal blood sugar but not yet diabetes). One group did short bursts of intense exercise (HIIT), the other did steady moderate exercise. Researchers measured changes in blood sugar, ch…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested a six-month home-based exercise program using elastic bands to prevent frailty in 120 adults aged 50-85 with type 2 diabetes and chronic kidney disease. The program aimed to improve muscle strength and daily functioning. Researchers measured changes in frailty s…

This study looked at whether telling overweight East Asians their genetic risk for type 2 diabetes, combined with using a Fitbit, could encourage them to be more active. 355 participants aged 40-60 were split into groups: some got just a Fitbit, others got their genetic risk plus…

This study looked at whether taking vitamin D or fish oil supplements every day can help prevent type 2 diabetes. Over 22,000 adults without diabetes took part. Researchers tracked who developed diabetes over time to see if the supplements made a difference.

This study tested a special version of the Diabetes Prevention Program designed specifically for men. 301 men with pre-diabetes or high risk took part to see if the program helped them lose weight and prevent type 2 diabetes. The program focused on lifestyle changes and was deliv…

This study tested whether a habit-formation smartphone app could help adults with prediabetes stay engaged in the National Diabetes Prevention Program. Researchers compared how many classes people attended and how long they stayed in the program between those who used the app and…

This completed study tested a 6-month program that taught nutrition and exercise to mothers and their children (ages 7-12) in the Yaqui Valley, Mexico. The goal was to improve lifestyle habits and prevent food insecurity, malnutrition, and related health problems like heart disea…

This study tested a family-focused lifestyle program designed to help rural Hispanic and non-Hispanic adults lower their risk for heart disease and type 2 diabetes. Over 500 participants took part in a culturally tailored program that encouraged healthy eating, physical activity,…

This study tested whether a lifestyle modification program—including diet advice, exercise plans, and mobile reminders—could reduce the risk of prediabetes progressing to type 2 diabetes. 124 adults with prediabetes participated. The goal was to see if simple, everyday changes co…

This study tested a mobile, web-based program called STEPS to help prevent type 2 diabetes in Hispanic adults living in rural areas. 179 participants at high risk for prediabetes were randomly assigned to use STEPS or receive usual care for three months. Researchers measured weig…

This pilot study tested a 12-week telehealth lifestyle program for Black adolescent girls with obesity who are at risk for type 2 diabetes, along with their female caregivers. The program included weekly group wellness sessions (mindfulness, nutrition, dance) and home cooking exp…

This study tested a new way to prevent type 2 diabetes in people with pre-diabetes. Participants wore a continuous glucose monitor (CGM) on their arm and received AI-generated educational videos on their smartphone. The goal was to see if this combination could help lower average…

This study tests whether a walking program that uses FitBit tracking and personalized coaching can help people who recently had a leg amputation due to diabetes or peripheral artery disease become more physically active. Participants will use a FitBit to monitor their steps and r…

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This trial tests a set of conversation cards, called QBSafe, designed to help people with type 2 diabetes talk with their doctors about what matters most in their daily lives. The goal is to see if these conversations can reduce the burden of living with diabetes and improve well…

This trial tests whether a quick cold spray on the skin before a subcutaneous insulin injection can reduce pain compared to a placebo spray. Adults in the emergency department who need at least two insulin injections receive both sprays in random order, rating their pain after ea…

This study tested two local anesthesia techniques—intraseptal and periodontal ligament—in 120 adults with controlled type 2 diabetes who needed a tooth pulled. The goal was to see which method numbs better and how it affects blood pressure and heart rate. Results help dentists ch…

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This study tested two ways to clean teeth and gums in 82 people with poorly controlled type 2 diabetes and severe gum disease. One method cleaned all teeth in one day (full mouth disinfection), while the other cleaned one quarter of the mouth at a time over four weeks. Researcher…

This study tested a new insulin dosing calculator for adults with type 2 diabetes when they are admitted to the hospital. The goal was to see if the calculator helps control blood sugar without causing dangerously low levels. Thirty-eight participants received their initial insul…

This study tested problem-solving therapy (PST) for adults with type 2 diabetes or heart disease who also have poor mental well-being. PST is a structured talk therapy where patients list their problems, weigh solutions, and take action. The trial involved 147 patients in general…

This study tested whether a special set of exercises, called modified Otago exercises, could help people with type 2 diabetes who have nerve damage in their feet. 38 participants did these exercises for 8 weeks, and researchers measured their balance, joint position sense, blood …

This study looked at whether adding foot exercises to aerobic exercise helps people with type 2 diabetes and nerve damage in their legs. 74 participants were split into three groups: usual medical care, aerobic exercise only, or aerobic exercise plus foot exercises. The goal was …

This study looked at whether progressive relaxation exercises can help people with type 2 diabetes who have nerve pain, fatigue, and poor sleep. 88 adults took part. The goal was to see if these simple exercises could improve their symptoms and quality of life.

This study tested whether using electrical stimulation on the thigh muscles could improve how the body uses insulin in people with type 2 diabetes. Eighteen adults with type 2 diabetes who were overweight and on oral medication received a single session and then six days of daily…

This study tested whether a 6-month exercise program called Vivifrail could improve physical function, thinking skills, and quality of life in 80 older adults (ages 60-80) with type 2 diabetes and frailty. Participants exercised three times a week, with increasing intensity over …

This study looked at whether a diabetes education program plus cinnamon supplements could help adults with type 2 diabetes who have painful nerve damage in their feet. Sixty-two participants were split into two groups and followed for six months. Researchers measured changes in b…

This study looked at whether eating 3 low-calorie meals a day is better than 5 small meals for blood sugar control and weight loss in people with type 2 diabetes who are overweight or obese. Fifty adults aged 40-70 followed one of the two meal plans for 11 weeks. Researchers meas…

This study tested whether Baduanjin, a traditional Chinese exercise that combines gentle movements with mindful breathing, can help people with type 2 diabetes. 42 adults aged 50-60 with diabetes for 5-10 years took part. Researchers measured changes in blood sugar, quality of li…

This study tested whether specific foot muscle exercises could improve how pressure is distributed on the feet in people with type 2 diabetes. 37 adults were randomly assigned to either a training group or a control group. The training group did exercises like toe movements and s…

This study tested whether the diabetes drug acarbose, adjusted using continuous glucose monitoring (CGM), can reduce pain in adults with painful diabetic neuropathy. 170 participants with type 2 diabetes and high blood sugar swings were enrolled. The goal was to see if controllin…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

This study tested whether a ceramide-based foot cream (CeraVe) applied twice daily for two weeks could reduce water loss and dryness in the feet of people with non-insulin dependent diabetes. Ten adults with moderate to severe dry feet participated. The goal was to see if the cre…

This study looked at whether drinking specialty coffee (a type high in a natural compound called chlorogenic acid) could improve memory, thinking speed, and attention in people with type 2 diabetes. Forty coffee drinkers with diabetes took part, drinking either specialty or regul…

This study tested whether a 12-session group therapy program for binge eating disorder could also improve blood sugar control in adults with type 2 diabetes. 34 participants received the therapy or were placed on a waitlist. Researchers measured changes in binge eating episodes a…

This pilot study tested a digital program called FoodSteps for adults who struggle with binge eating, have type 2 diabetes, and face food insecurity. Participants used a mobile app and received coaching and a weekly stipend for 16 weeks. The goal was to see if the program is feas…

This small study tested whether gummy candies made with maqui berry could help overweight adults control their blood sugar after eating a carb-rich meal. Ten participants ate white bread alone, or with maqui berry gummies, and had their blood sugar and antioxidant levels measured…

This study looked at whether teaching people with type 2 diabetes about good sleep habits can improve their sleep quality and blood sugar control. One hundred adults with type 2 diabetes and poor sleep took part. Half received sleep hygiene education and kept a sleep diary for tw…

This study tested whether adding spiritual care to standard diabetes care helps adults with type 2 diabetes. 80 participants received either usual care or usual care plus a structured spiritual program. Researchers measured changes in psychological resilience, distress, and blood…

This pilot study tested whether a structured foot-ankle exercise program could help adults with type 2 diabetes manage nerve pain, stress, and quality of life, compared to walking or standard care. Over 12 weeks, 108 participants either did foot-ankle exercises, walked regularly,…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This study looks at how type 2 diabetes affects young people aged 12 to 25. Researchers want to see if giving the pancreas a 2-week rest with insulin shots can improve its ability to make insulin. Participants take metformin, follow a diet, and some also get insulin. The study al…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study analyzed health records of over 200,000 adults with obesity and type 2 diabetes to see if taking GLP-1 drugs (like Ozempic) before a cancer diagnosis is linked to better survival and fewer complications after cancer. The researchers compared GLP-1 users to those on oth…

This study looks at how the body processes arginine, a natural nutrient, in teenagers with type 2 diabetes. Researchers will give participants arginine and measure its effect on insulin production. The goal is to better understand the disease and see if arginine could be a safe, …

This study asks whether pioglitazone, a widely used diabetes medication, might reduce bone density in people with type 2 diabetes. Researchers will compare bone mineral density and bone turnover markers in adults aged 30-55 who take pioglitazone versus those who do not. The goal …

This study investigates the link between gut bacteria and diabetic kidney disease, a common complication of type 2 diabetes. Researchers will analyze blood, urine, and stool samples from 556 adults with the condition to look for bacterial and metabolic markers. The goal is to und…

This study tests whether teaching Latino patients with type 2 diabetes how to use patient portals and telehealth during a hospital stay helps them manage their care after discharge. 84 adults will receive either one-on-one digital training or standard care. The main goal is to se…

This early-stage trial is testing an experimental drug called HTD4010, a synthetic version of a natural peptide that may help the pancreas regenerate insulin-producing cells. The study enrolls healthy, non-diabetic volunteers to receive single ascending doses of the drug or a pla…

This study looks at whether people with type 2 diabetes who eat more dairy products (like milk, cheese, and yogurt) during an intensive lifestyle program have better blood sugar control and weight maintenance. Researchers will track changes in A1C, weight, and cholesterol in abou…

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This study explores whether compounds in cannabis, like THC and CBD, can reduce inflammation and improve how the body responds to insulin. Researchers will measure blood markers of inflammation and insulin sensitivity in people across the weight spectrum, both after a single use …

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

This Phase 1 trial tests two experimental drugs (L03RD1 and L03RD2) in 48 healthy adults to see how safe they are and how the body processes them. Participants take the drugs alone or together in a single dose. The study does not aim to treat diabetes, but to gather information f…

This study investigates how specific fat molecules called diacylglycerols and sphingolipids inside muscle cells influence insulin resistance. Researchers will measure these lipids in different parts of muscle cells before and after weight loss or exercise in people with obesity, …

This study looks at whether drinking a beverage with artificial sweeteners (erythritol or xylitol) changes how blood platelets clump together, which could affect heart attack or stroke risk. Researchers will measure platelet activity and blood levels of these sweeteners in 50 hea…

This early-stage study in 32 healthy adults looks at how a new drug called AZD5004 changes the way the body processes two diabetes medications, mitiglinide and pioglitazone. The goal is to understand potential drug interactions, not to treat any disease. Participants take the dru…

This study uses healthcare claims data from nearly 24,000 people to see if it can reproduce the results of the EMPEROR-Reduced trial, which tested the diabetes drug empagliflozin against sitagliptin in heart failure patients. The goal is not to test a new treatment, but to learn …

This study looks at health insurance claims from about 30,000 people with type 2 diabetes to see if real-world data can produce similar results to a large clinical trial called REWIND. The goal is to learn when and how to trust real-world data for answering medical questions. No …

This study uses healthcare claims data from nearly 40,000 people to see if the results of a major clinical trial (EMPEROR-Preserved) can be reproduced in a real-world setting. Researchers are comparing two diabetes drugs, empagliflozin and sitagliptin, in patients with heart fail…

This observational study investigates how different levels of gum health influence asprosin (a hormone) and total oxidant/antioxidant levels in people with type 2 diabetes. Researchers will collect fluid from around the gums and blood samples from 67 participants to compare these…

This study tested whether an online diabetes self-management program could help newly diagnosed adults with type 2 diabetes learn about their condition and improve health measures. 123 participants were split into online education, face-to-face education, or a no-education contro…

This study investigates how the liver processes nutrients after a meal in healthy individuals and in patients with fatty liver disease or cirrhosis. Researchers will take blood samples and liver biopsies after fasting or eating a standardized meal, and after a glucagon injection.…

This study investigates whether type 2 diabetes changes the levels of key growth factors and inflammatory markers in Albumin Platelet-Rich Fibrin (Alb-PRF) membranes—a blood-derived material used to support wound healing and dental tissue repair. Researchers will compare Alb-PRF …

This study tested whether training healthcare providers to prescribe continuous glucose monitors (CGMs) increases their use among patients with type 2 diabetes. Researchers trained clinic staff at three community health centers serving a mostly Hispanic/Latino population. They th…

This observational study investigates whether a substance in the blood called nociceptin is linked to overactive nerves in people who have both type 2 diabetes and metabolic fatty liver disease. Researchers will compare 50 patients with both conditions to 50 healthy volunteers, m…

This study analyzed health records of over 118,000 adults with obesity, type 2 diabetes, and related heart, kidney, and liver conditions. Researchers compared people who added a second type of diabetes drug (GLP-1 or SGLT2) early to those who did not. The goal was to see if early…

This completed study looked at how well Danish hospitals followed official guidelines for managing blood sugar in people with diabetes who had major, non-cardiac surgery. Researchers reviewed records from over 13,000 patients treated between 2017 and 2023. They focused on whether…

This completed study at Northwestern University brought together 35 patients, caregivers, and healthcare providers to discuss how to improve the identification and management of high blood sugar (hyperglycemia) and diabetes during hospital stays and when moving between care setti…

This study analyzed health records from over 450,000 adults with obesity and type 2 diabetes to see if adding a GLP-1 or SGLT2 drug early improves survival and kidney health. Researchers compared those who added the other drug class within 90 days to those who added a different d…

This study checked how well two continuous glucose monitors (Dexcom G6 and FreeStyle Libre) work when oxygen levels are low. Thirty people with type 1 or type 2 diabetes took part. Researchers compared sensor readings to blood tests during controlled low-oxygen conditions to see …

This study analyzed health records from nearly 195,000 people in Denmark, Sweden, and Norway to see if semaglutide (the drug in Ozempic and Rybelsus) is linked to a higher risk of pancreatic cancer. Researchers compared new users of semaglutide to new users of other diabetes medi…

This completed study observed 40 people with type 2 diabetes to find blood markers that could identify those at risk for a serious liver condition called NASH. Researchers measured liver stiffness and calculated scores like FIB-4 and ELF to see which patients might have liver sca…

This early-stage study tested different oral versions of the drug AZD5004 in 65 healthy adults. The goal was to see how the body absorbs and processes each version, and whether taking it with food changes those effects. The study is complete, but results are not yet available.

This study analyzed health records from nearly 75,000 people with type 2 diabetes in Hungary to see if different diabetes medications are linked to cancer risk. Researchers compared various drugs, including metformin, and adjusted for age, gender, and other health factors. The go…

This study looked at how a diabetes medicine called ertugliflozin affects fat tissue around the heart. Researchers took fat samples from 61 adults with type 2 diabetes and heart disease during heart surgery. They tested the fat in a lab to see if the drug improved how the fat cel…

This study tested whether an educational video and action plan, called 'Prepare for Your Diabetes Care,' could help older adults (75+) with type 2 diabetes reduce their risk of dangerously low blood sugar. Over 12 months, 669 participants were randomly assigned to receive the int…

This completed study in India looked at 362 hospital patients to understand how common high blood sugar (hyperglycemia) is and how it affects their hospital stay. Researchers measured blood sugar levels, checked for diabetes, and looked at body composition and certain blood marke…

This study looked at how gut bacteria affect the development of type 2 diabetes and help personalize treatment. Researchers followed 100 adults newly diagnosed with type 2 diabetes who had not taken diabetes medication before. They analyzed stool samples and blood tests, then ass…

This completed study tested a 4-week group program designed to boost confidence (self-efficacy) in managing type 2 diabetes. Sixteen adults from primary health centers in Indonesia took part. Researchers measured changes in self-care behaviors and self-efficacy using questionnair…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at how quickly bringing high blood sugar under control, combined with moderate treadmill walking, affects certain proteins linked to bone health in people with type 2 diabetes. The goal was to understand why some patients develop a rare but serious joint conditi…

This study looked at 295 adults with type 2 diabetes in Kharga City, Egypt, to see how many also had other conditions like high blood pressure, heart disease, kidney disease, or eye problems. Researchers used blood tests, urine tests, and heart tracings to check for these issues.…

This study looked at the genes of 40 adults with type 2 diabetes to find DNA differences that might explain why some develop Charcot foot, a serious joint problem. Half of the participants had Charcot foot, and half did not. Researchers compared their exomes (the part of DNA that…

This study looked at how a single dose of HR17031 moves through the body in people with mild, moderate, severe, or end-stage kidney disease compared to those with normal kidneys. A total of 24 adults with type 2 diabetes took part. The goal was to understand how kidney function a…

This early-stage trial tested the safety and how the body processes a new drug called HR011408 in 62 healthy adults. Participants received two different versions of the drug to compare them. The goal was to check for side effects and measure drug levels in the blood, not to treat…

This study looked at 115 adults with prediabetes to understand why different people develop the condition. Researchers tested how each person's body responds to different foods, aiming to create personalized diet plans that prevent diabetes. The goal was to find biological marker…

This study looked at how much blood sugar levels go up and down during the day in frail or disabled patients over 75 with diabetes who use basal insulin. Researchers used a continuous glucose monitor for 5 days to compare two types of insulin: human NPH and long-acting analogues.…

This early-stage trial tested two experimental oral drugs, HL1113-R1 and HL1113-R2, in 35 healthy adults to see if they are safe and how the body processes them. The drugs are being developed for high blood pressure and type 2 diabetes. Participants took the drugs alone and toget…

This study looked at whether exercising in the morning (7-11am) or afternoon (4-8pm) makes a difference for people with type 2 diabetes or prediabetes. Thirty-six adults did 10 supervised exercise sessions at a high intensity. Researchers measured changes in body weight, blood su…

This early-stage study tested a new drug (HL1113) in 37 healthy adults to see how the body processes it. The drug combines two existing medicines for high blood pressure and type 2 diabetes. Participants took the drug in different ways to compare safety and drug levels. The resul…

This completed study looked at 126 people with different fat distribution patterns—including those with lipodystrophy (abnormal fat loss or distribution), obesity, and normal weight—to understand how fat tissue relates to insulin resistance and immune signals. Researchers measure…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This study tested whether a pop-up alert in the electronic medical record could help doctors remember to refer patients with fatty liver disease (NASH) to a liver specialist. Thirty doctors from internal medicine, family medicine, and endocrinology took part. The goal was to see …

This study looked at whether taking vitamin C (and vitamin E) supplements for 8 weeks can make red blood cells more flexible in people with type 2 diabetes. Stiff red blood cells can lead to tiny blood vessel damage. Researchers measured red blood cell flexibility before and afte…

This early-stage trial looked at how a single 50mg dose of pyroglutamate rongliflozin capsules behaves in 32 adults with mild or moderate liver damage and type 2 diabetes, compared to healthy volunteers. Researchers measured drug levels in the blood and tracked side effects to un…

This completed study looked at 172 people with and without HIV to understand why those with HIV have a higher risk of diabetes. Researchers examined fat tissue and immune cells to see if chronic immune activation in fat contributes to insulin resistance. The goal was to learn how…

This study looked at how different levels of exercise change the bacteria in the gut of people with type 2 diabetes. Forty adults with type 2 diabetes did either moderate or high-intensity endurance and strength training for 16 weeks. Researchers compared changes in blood sugar a…

This study looked at how short periods of low oxygen (from holding your breath) affect blood sugar levels after drinking a sugary drink. Researchers tested 20 healthy adults, people with prediabetes, and people with type 2 diabetes. The goal was to learn more about how oxygen lev…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study looked at how inherited gene variants influence the body's response to two common type 2 diabetes medications, metformin and glipizide. Over 1,000 participants took each drug and had their glucose and insulin levels measured. The goal was to understand why some people …

This study looks at how the body processes HRS9531, an experimental diabetes drug, in people with different levels of kidney function. Researchers gave a single dose to 32 volunteers—some with healthy kidneys and some with mild impairment—and measured drug levels over time. The g…

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This study analyzed data from over 16,500 adults with chronic heart failure who were part of a remote monitoring program in France. Researchers looked at how having diabetes, other health conditions, and short-term weight changes were linked to survival. The goal was to better un…

This completed trial tested whether electronic alerts in the emergency room can improve care for people with type 2 diabetes. The alerts prompted doctors to order an A1c test when blood sugar was very high, and to consider admitting the patient for better diabetes management. Res…

This completed study from Denmark looked at 101 people to see if nerve damage from type 2 diabetes is linked to memory and thinking problems. Researchers compared people with and without diabetes using tests of thinking skills, nerve function, and brain scans. The goal was to und…

This completed Phase 4 trial looked at how evolocumab (Repatha), a cholesterol-lowering drug, affects markers of inflammation and blood clotting in 41 people with type 2 diabetes and heart disease. Participants received either evolocumab or a placebo injection every 4 weeks for 1…

This early-stage study looked at how two different tablet versions of the experimental diabetes drug HRS-7535 are absorbed in the body, and whether food changes that. It involved 24 healthy adults who took the tablets under fasting and fed conditions. The goal was to compare the …

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study worked with community groups to screen Hispanic/Latinx adults for kidney disease and diabetes, then referred them to a primary care doctor. It also gave local clinics guidelines to help doctors screen and treat Hispanic and Black patients with diabetes. The goal was to…

This completed Phase 1 trial tested how four diabetes medications (HRS-1780, henagliflozin, metformin, and HRS-7535) affect each other's levels in the body. Twenty-four healthy men took the drugs in a fixed order, and researchers measured drug concentrations and side effects. The…

This study looked at two easy methods to measure hidden belly fat in 110 adults with type 2 diabetes. Researchers compared a simple waist measurement to a device that sends a mild electrical signal through the body. The goal was to see which method better relates to heart disease…

This pilot study tested whether taking metformin 30 or 60 minutes before a meal affects carbohydrate absorption in people with obesity and prediabetes or type 2 diabetes. One participant completed three oral glucose tolerance tests—one without metformin, one with metformin taken …

This completed study in 130 adults with type 2 diabetes and fatty liver disease tested whether a blood marker called adiponectin can predict how well certain diabetes drugs reduce liver fat. Participants received either an SGLT2 inhibitor, a GLP-1 receptor agonist, or both for si…

This pilot study tested whether continuous glucose monitors (CGMs) can help manage blood sugar in hospitalized adults with diabetes. Forty patients wore a Dexcom G6 device during their hospital stay to track glucose levels. The goal was to see if CGM could reduce dangerous low or…

This completed study analyzed health records from over 2 million people with type 2 diabetes to see if those taking dapagliflozin had a different risk of breast or bladder cancer compared to those on other diabetes medications. Researchers tracked cancer diagnoses for up to 12 ye…

This pilot study looked at whether removing oxysterols (harmful compounds in cooked animal foods) from the diet could improve insulin production in African Americans with prediabetes or early type 2 diabetes. Twelve participants ate a plant-based diet free of oxysterols for a per…

This completed early-phase study tested different doses of fatty acids (Intralipid) in 9 healthy volunteers to find the dose that causes mild insulin resistance. The goal was to create a reliable model for future diabetes research. Participants received low or medium doses of fat…

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This completed study in Kazakhstan looked at 240 adults recently diagnosed with diabetes. Researchers measured blood sugar, insulin resistance, and immune markers to understand how different forms of diabetes develop. The goal is to help doctors diagnose and treat adult-onset dia…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. Researchers wanted to see how many had high levels of a protein called albumin in their urine, which is a sign of kidney damage. They also tracked how these levels changed over a …

This study tested a new insulin called insulin icodec in 18 children and teenagers (ages 10 to 17) with type 2 diabetes. Each participant received a single injection based on their body weight, and researchers measured how the insulin moved through their blood over time. The goal…

This completed phase 1 study tested how different levels of kidney function affect the processing of a single dose of the experimental drug NNC0519-0130. Thirty-six adults with type 2 diabetes and varying kidney function (normal to severely impaired) received one injection. Resea…

This study looked at how the drug finerenone affects kidney blood vessels and stress levels in people with type 2 diabetes. Researchers measured blood flow and oxidative stress in the kidneys of 91 adults. The goal was to understand how finerenone works, not to test a cure or tre…

This study looked at 470 adults aged 18-75 with type 2 diabetes and metabolic syndrome to identify their Traditional Chinese Medicine (TCM) patterns. Researchers used a standard questionnaire and four TCM diagnostic methods to classify each person's syndrome. The goal was to bett…

This study combines data from four earlier trials to track 262 adults with type 2 diabetes and obesity for up to 13 years. Researchers want to see if bariatric surgery keeps blood sugar under control longer than medical or lifestyle changes. Participants were originally in random…

This study examined 24 adolescents (ages 14-18) with and without depression to see if their brains respond differently to insulin. Participants received insulin or a placebo nasal spray, and MRI scans measured brain activity and blood flow. The goal was to understand if brain ins…

This study looked at whether using a continuous glucose monitor (CGM) is better than standard finger-prick checks for managing blood sugar in pregnant women with type 2 diabetes. Sixteen women participated, and researchers measured how well blood sugar stayed in a healthy range a…

This study looked at whether keeping indoor temperature at 26°C (about 79°F) can prevent dangerous heat strain in older adults during a multi-day heat wave. Researchers exposed 18 adults aged 60-85 to simulated heat conditions over three days and two nights, measuring core temper…

This study measured certain inflammatory markers in the saliva and blood of 126 people with type 2 diabetes, some of whom also had kidney disease (diabetic nephropathy). The goal was to see if these markers differ based on gum health. Researchers hope to better understand the lin…

This study tested whether replacing sitting with standing or walking during daily life could improve blood sugar levels in South Asian adults who are overweight or obese. Eighteen participants followed two regimens: one with more sitting and one with less sitting. The goal was to…

This small pilot study looked at whether aprepitant, a drug used for nausea, can reduce aldosterone (a hormone that raises blood pressure) in people with type 2 diabetes and low-renin hypertension. Five participants took either aprepitant or a placebo for two weeks, then switched…

This study tested five different blood glucose meters in 501 adults with type 1 or type 2 diabetes who use insulin. Participants used multiple devices to see how accurate and reliable each meter is in real-world conditions. The goal was to help people with diabetes and their doct…

This study looked at how bariatric surgery changes the bacteria in the mouths of people with and without type 2 diabetes. Researchers collected blood and plaque samples before and after surgery from 102 participants. The goal was to understand if diabetes alters mouth bacteria in…

This completed study looked at how the hormone GIP changes blood flow in the gut after a sugary drink in 10 people with type 2 diabetes. Researchers used a GIP-blocking drug to see what happens when GIP is stopped. The goal was to better understand GIP's role in digestion and met…

This study compared two types of gastric bypass surgery in 40 adults with obesity and type 2 diabetes. Researchers measured changes in gut hormones like GLP-1 to see which surgery better improves insulin resistance and diabetes. The goal was to understand how each surgery affects…

This study tested a personalized medicine approach in 239 people with type 2 diabetes who use multiple daily insulin injections. Researchers used blood tests (C-peptide and GAD antibodies) to see if some patients could safely stop their mealtime insulin and switch to other diabet…

This study looked at whether giving a carbohydrate drink (yogurt with honey) before elective abdominal surgery is safe and helpful for people with type 2 diabetes. 120 patients were split into three groups: non-diabetic controls, non-diabetic with the drink, and diabetic with the…

This small pilot study explored whether advanced heart imaging can detect hidden strokes in people who have never had atrial fibrillation but are at high risk due to conditions like diabetes or heart failure. Researchers used brain MRIs to find silent, symptom-free strokes and li…

This study looked at 159 adults with type 2 diabetes to see if the way they are introduced to a continuous glucose monitor (CGM) affects their blood sugar control. One group received a nutrition-focused approach, while the other used a self-directed method. The main goal was to m…

This study looks at why dapagliflozin, a diabetes drug, can raise 'bad' cholesterol levels. Researchers will track how the body makes and clears cholesterol in 28 adults with type 2 diabetes over 6 months. Half the participants will get dapagliflozin, the other half a placebo. Th…

This study looked at 1500 people with obesity (BMI 25 or higher) to find out what helps diabetes go away and other health issues improve after weight-loss surgery. Researchers collected health data before and after surgery, including weight, blood sugar, and quality of life. The …

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This study tested a program called DM-BOOST para Latinx, designed to help Latinx adults with type 2 diabetes better manage their condition. The program used behavioral economics and technology to improve outreach and self-management support. Twenty participants were involved to s…

This completed study looked at how people change their eating habits after starting GLP-1 drugs like Ozempic or Mounjaro for weight or diabetes. Researchers tracked 37 adults using dietary records and questionnaires to see if it's feasible to study diet changes this way. The goal…

This study looked at over 133,000 adults with newly diagnosed type 2 diabetes who were smokers. Researchers wanted to see if switching from regular cigarettes to e-cigarettes could lower the risk of heart problems and diabetes complications. The study used health records to compa…

This study looked at how quickly the drug BGM0504 enters the blood and how long it stays in the body. Researchers compared 34 people with normal kidney function to those with mild or moderate kidney problems. The goal is to understand if kidney function changes how the drug shoul…

This study looked at how brown adipose tissue (brown fat) works in people with type 2 diabetes. Researchers used special PET scans with a fat-based tracer to measure brown fat activity more accurately than before. The study included 6 participants and aimed to better understand h…

This study tested whether taking acetaminophen (like Tylenol) interferes with a new continuous glucose monitor called Biolinq. Thirty-one adults with diabetes wore the Biolinq sensor and a standard CGM for three days. On day three, they took acetaminophen and researchers compared…

This study looked at how diabetes changes the way certain fats (arachidonic acid) are processed in fatty plaques that build up in the carotid artery. Researchers compared plaque samples from 204 diabetic and non-diabetic patients undergoing surgery for carotid stenosis. The goal …

This study looked at how tasting fatty acids (like linoleic acid) changes levels of gut hormones in healthy people, those with type 2 diabetes, and obese individuals without diabetes. Researchers measured hormone levels in blood after oral stimulation and compared taste sensitivi…

This study looked at how semaglutide, a diabetes medicine, affects the kidneys in people with type 2 diabetes and chronic kidney disease. 106 participants received either semaglutide or a placebo injection once a week for about a year. Researchers used MRI scans, blood and urine …

This study looked at a recently discovered hormone called 26RFa in 62 women who were obese, some with type 2 diabetes and some without. Researchers measured the hormone levels before and after weight-loss surgery (sleeve gastrectomy) and compared them to healthy-weight volunteers…

This study tested whether people with diabetes can use a smartphone game to monitor their vision at home, instead of always going to the clinic. 55 participants at high risk for diabetic retinopathy played vision games on their phones for 6 months. The goal was to see if people w…

This study explored whether personality type (A or B) and stress levels differ between people with type 2 diabetes who have foot wounds and those who do not. Researchers used questionnaires to measure personality, stress, depression, and quality of life in 66 participants. The go…

This study looked at whether a special education program could help people with diabetic foot (a serious complication of type 2 diabetes) become more prepared for disasters like earthquakes or floods. 68 patients took part, with some receiving the education and others getting usu…

This study worked with Black adults aged 55 and older who have type 2 diabetes to understand why they sit for long periods and how to help them sit less. Researchers used interviews and activity monitors to learn about the social and personal factors that lead to prolonged sittin…

This study looked at whether GLP-1 agonists, a class of diabetes drugs, can reduce fat buildup in the heart muscle of people with type 2 diabetes. Researchers used MRI scans to measure heart fat before and after 6 months of treatment in 42 adults over 50. The goal was to understa…

This completed study looked at healthcare claims data from over 58,000 people to see if it could reproduce the results of the STEP-HFpEF DM trial, which tested semaglutide for heart failure with preserved ejection fraction in people with type 2 diabetes. Researchers compared new …

This completed study looked at whether information from healthcare claims (like insurance records) can be used to get similar results as a real clinical trial. Researchers compared people with type 2 diabetes and heart failure who started taking tirzepatide to those who started t…

This study looked at how insulin use affects breathing and recovery after exercise in people with type 2 diabetes. 70 adults completed breathing tests and a 6-minute walk. The goal was to see if insulin users have different breathing strength or recovery patterns.

This study tested whether a generic version of the diabetes medication Synjardy XR (empagliflozin and metformin) works the same as the brand-name drug. Thirty-two healthy adults took a single dose of either the generic or brand tablet under fasting conditions. The goal was to see…

This study looked at 100 people aged 40 and older who had cataract surgery. Half had type 2 diabetes and half did not. Researchers measured changes in the thin cell layer on the inside of the cornea before and after surgery to see if diabetes affects recovery. The goal is to help…

This study looked at 2188 adults with type 2 diabetes or prediabetes to see if three simple blood test scores could predict heart and metabolic risk. The researchers calculated the triglyceride-glucose index, atherogenic plasma index, and systemic immune-inflammation index from r…

This study looked at how well 60 adults with type 2 diabetes could follow a Mediterranean diet for 12 months. Researchers wanted to see what makes it hard or easy to stick with this healthy eating plan. The goal is to find ways to help more people with diabetes adopt this diet.

This study looked at medical records of over 21,000 adults with type 2 diabetes and COPD to see if a diabetes drug called SGLT2 inhibitor lowers the chance of getting lung cancer compared to an older drug, sulfonylurea. Researchers did not give anyone new medicine; they just anal…

This study examined whether type 2 diabetes influences how well a dental procedure called pulpotomy works in adults. Researchers compared 70 diabetic and non-diabetic patients who had a molar treated for irreversible pulpitis. They checked the tooth's health, symptoms, and X-ray …

This study tested how well the GLUCUBE system measures blood sugar in 52 adults with type 2 diabetes. Participants used the device at home and compared its accuracy to a standard finger-stick monitor. The goal was to see if the system becomes more accurate with longer use.