Could a Weight-Loss pill also crush kidney stones?
NCT ID NCT04621929
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested whether a combination of phentermine and topiramate, two drugs used for weight loss, could help shrink uric acid kidney stones in obese people with type 2 diabetes or pre-diabetes. Nineteen participants were randomly assigned to receive the drug combo or continue their usual care (citrate, allopurinol, diet). The main goal was to see if stone size changed over 18 months, along with weight, urine pH, and blood sugar levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Phentermine and topiramate (weight-loss drug combination)
- What this could lead to
- If it works, this could offer a way to treat both obesity and uric acid kidney stones with one medication, reducing the need for separate treatments.
- What could go wrong
- This was a very small pilot study with only 19 participants, so results may not apply to everyone. The drug combination can cause side effects like dizziness, tingling, and birth defects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Florida
Gainesville, Florida, 32610, United States
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