Could a Weight-Loss pill also crush kidney stones?
NCT ID NCT04621929
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested whether a combination of phentermine and topiramate, two drugs used for weight loss, could help shrink uric acid kidney stones in obese people with type 2 diabetes or pre-diabetes. Nineteen participants were randomly assigned to receive the drug combo or continue their usual care (citrate, allopurinol, diet). The main goal was to see if stone size changed over 18 months, along with weight, urine pH, and blood sugar levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Phentermine and topiramate (weight-loss drug combination)
What this could lead to
If it works, this could offer a way to treat both obesity and uric acid kidney stones with one medication, reducing the need for separate treatments.
What could go wrong
This was a very small pilot study with only 19 participants, so results may not apply to everyone. The drug combination can cause side effects like dizziness, tingling, and birth defects.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Florida
Gainesville, Florida, 32610, United States