Could a common diabetes drug ease leg pain for millions?
NCT ID NCT05132439
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether metformin, a standard diabetes drug, can improve walking ability in people with peripheral artery disease (PAD) who experience leg pain during activity. Researchers will give 200 Veterans either metformin or a placebo for several months and measure changes in walking distance. The goal is to find a safe, effective treatment for a condition that currently has few options.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Metformin (extended-release)
What this could lead to
If it works, this could provide a safe, affordable treatment to help people with PAD walk farther and have less leg pain.
What could go wrong
This is still an early-stage test in a specific group (Veterans), and metformin may not improve walking more than a placebo. Side effects like stomach upset are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
RECRUITINGPittsburgh, Pennsylvania, 15240, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••