Can aspirin and strong statins shield hearts with heavy calcium buildup?
NCT ID NCT06676280
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times
Summary
This study is testing whether taking daily aspirin (100 mg) along with a high-intensity statin can prevent heart attacks, strokes, and other serious cardiovascular events in people aged 40–75 who have severe coronary artery calcification (calcium score ≥300). About 5,000 participants will be randomly assigned to different combinations of aspirin and statin therapy. The goal is to find the best way to reduce risk in this high-risk group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Aspirin and high-intensity statin therapy
- What this could lead to
- If successful, this could show that a combination of daily aspirin and a strong statin significantly reduces the risk of heart attacks, strokes, and other cardiovascular events in people with severe coronary calcification.
- What could go wrong
- This is a Phase 4 trial, but results may not apply to everyone. Aspirin increases bleeding risk, and high-intensity statins can cause muscle pain or liver issues. The study is large but still may not prove benefit for all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Asan Medical Center
RECRUITINGSeoul, South Korea
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Chonnam National University Hospital
RECRUITINGGwangju, South Korea
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Chungbuk National University Hospital
RECRUITINGCheonju, South Korea
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Chungnam National University Hospital
RECRUITINGDaejeon, South Korea
-
Dong-A University Hospital
NOT_YET_RECRUITINGBusan, South Korea
-
GangNeung Asan Hospital
RECRUITINGGangneung, South Korea
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Gyeongsang National University Changwon Hospital
RECRUITINGChangwon, South Korea
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Haeundae paik hospital, inje university
RECRUITINGBusan, South Korea
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Hallym University Chuncheon Sacred Heart Hospital
NOT_YET_RECRUITINGChuncheon, South Korea
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Hallym University Medical Center
NOT_YET_RECRUITINGAnyang, South Korea
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Hanil General Hospital
RECRUITINGSeoul, South Korea
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Hanyang University Seoul Hospital
RECRUITINGSeoul, South Korea
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Incheon St. Mary's Hospital, The Catholic University of Korea
NOT_YET_RECRUITINGIncheon, South Korea
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Inje University Busan Paik Hospital
RECRUITINGBusan, South Korea
-
Jeonbuk National University Hospital
RECRUITINGJeonju, South Korea
-
Kangbuk Samsung Hospital
NOT_YET_RECRUITINGSeoul, South Korea
-
Kangwon National University Hospital
RECRUITINGChuncheon, South Korea
-
Keimyung University Dongsan Medical Center
RECRUITINGDaegu, South Korea
-
Korea University Guro Hospital
RECRUITINGSeoul, South Korea
-
Kwangju Christian Hospital
NOT_YET_RECRUITINGKwangju, South Korea
-
Kyungpook National University Hospital
RECRUITINGDaegu, South Korea
-
SAM hospital
NOT_YET_RECRUITINGAnyang, South Korea
-
Sejong General Hospital
RECRUITINGBucheon-si, South Korea
-
Seoul National University Bundang hospital
RECRUITINGSŏngnam, South Korea
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Severance Hospital
RECRUITINGSeoul, South Korea
-
The Catholic University of Korea Seoul St. Mary's Hospital
NOT_YET_RECRUITINGSeoul, South Korea
-
The Catholic University of Korea, Daejeon St. Mary's Hosptial
RECRUITINGDaejeon, South Korea
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The Catholic University of Korea, Eunpyeong St. Mary's Hospitall
RECRUITINGSeoul, South Korea
-
The Catholic University of Korea, Uijeongbu St. Mary's Hospital
RECRUITINGUijeongbu-si, South Korea
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Ulsan University Hospital
RECRUITINGUlsan, South Korea
-
Yeungnam University Medical Center
NOT_YET_RECRUITINGDaegu, South Korea
-
Yongin Severance Hospital
RECRUITINGYongin, South Korea
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