Heart drug pelacarsen moves to Long-Term safety check in 600 patients

NCT ID NCT06875973

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 30, 2026 · Updated 3 times

Summary

This study is for people with high levels of Lp(a), a genetic risk factor for heart disease, who have already completed a prior pelacarsen trial. It will give them continued access to the drug while monitoring long-term safety and how well it keeps Lp(a) levels low. About 600 participants will receive monthly injections of pelacarsen for up to several years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pelacarsen (a monthly injection to lower Lp(a))
What this could lead to: If successful, this could confirm pelacarsen as a safe long-term treatment to lower Lp(a) and potentially reduce heart disease risk.
What could go wrong: This is an open-label extension, not a placebo-controlled trial, so results are less definitive. Long-term safety and effectiveness are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis atherosclerotic cardiovascular disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

Contacts and locations

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Locations

A&A Research Group Inc
RECRUITING

Miami, Florida, 33186, United States
AB Clinical Trials
RECRUITING

Las Vegas, Nevada, 89119, United States
Aa Mrc Llc
ACTIVE_NOT_RECRUITING

Flint, Michigan, 48504, United States
Aa Mrc Mhs
RECRUITING

Flint, Michigan, 48503, United States
Advanced Clinical Research LLC
RECRUITING

Bayamón, 00959, Puerto Rico
Alliance Medical Ministry
RECRUITING

Raleigh, North Carolina, 27610, United States
Anderson Medical Research
ACTIVE_NOT_RECRUITING

Ft. Washington, Maryland, 20744, United States
Angel City Research Inc
RECRUITING

Los Angeles, California, 90026, United States
Angiocardiac Care of Texas PA
RECRUITING

Houston, Texas, 77025, United States
Apex Cardiology Research Associates of Jackson
RECRUITING

Jackson, Tennessee, 38301, United States
Ascension Saint Agnes Heart Care
RECRUITING

Baltimore, Maryland, 21229, United States
Atlanta Heart Specialists LLC
RECRUITING

Tucker, Georgia, 30084, United States
Baptist Health South
RECRUITING

Miami, Florida, 33173, United States
C and A Clinical Trials
RECRUITING

Cape Coral, Florida, 33990, United States
CAIMED Center
RECRUITING

Ponce, 00716, Puerto Rico
CTMD Research
RECRUITING

Palm Springs, Florida, 33406, United States
CV Ins of the South
RECRUITING

Opelousas, Louisiana, 70570, United States
California Medical Research Associates Inc
ACTIVE_NOT_RECRUITING

Northridge, California, 91324, United States
Capitol Cardiology Associates
RECRUITING

Lanham, Maryland, 20706, United States
Cardiology Partners Clinical Research Institute
RECRUITING

Wellington, Florida, 33449, United States
Cardiology and Medicine Clinic PA
RECRUITING

Little Rock, Arkansas, 72204, United States
Cardiovascular Associates Research
RECRUITING

Covington, Louisiana, 70433, United States

Contact Email: •••••@•••••
Care Access Research
RECRUITING

Easton, Pennsylvania, 18045, United States
Chicago Clinical Research Inst
RECRUITING

Chicago, Illinois, 60607, United States
Clinical Research of South Nevada
RECRUITING

Las Vegas, Nevada, 89121, United States
Clinical Trials of Texas
ACTIVE_NOT_RECRUITING

San Antonio, Texas, 78229, United States
Columbus Clinical Services LLC
RECRUITING

Miami, Florida, 33125, United States
DBC Research USA
RECRUITING

Pembroke Pines, Florida, 33029, United States
Dallas Heart and Vascular Consultants PA
RECRUITING

Houston, Texas, 77084, United States
Dallas Heart and Vascular Consultants PA
ACTIVE_NOT_RECRUITING

Houston, Texas, 77084, United States
Dallas Heart and Vascular Consultants PA
RECRUITING

Houston, Texas, 77084, United States
David Turbay MD PLLC
RECRUITING

El Paso, Texas, 79905, United States
Discovery Clinical Trials
RECRUITING

Pflugerville, Texas, 78660-3015, United States
Dominion Medical Associates
ACTIVE_NOT_RECRUITING

Richmond, Virginia, 23219, United States
Dr Yolanda Figueroa Private Pr
RECRUITING

Humacao, 00791, Puerto Rico
Elite Clinical Research
RECRUITING

Jackson, Mississippi, 39202, United States
Epic Clinical Research
RECRUITING

Lewisville, Texas, 75057, United States
Excel Medical Clinical Trials LLC
ACTIVE_NOT_RECRUITING

Boca Raton, Florida, 33434, United States
FXM Clin Res Miramar LLC
ACTIVE_NOT_RECRUITING

Miramar, Florida, 33027, United States
Finlay Medical Research
ACTIVE_NOT_RECRUITING

Miami, Florida, 33126, United States
Flourish Research
ACTIVE_NOT_RECRUITING

Winter Park, Florida, 32789, United States
Flourish Research
RECRUITING

Winter Park, Florida, 32789, United States
Heart Care Associates P C
RECRUITING

Hopewell, Virginia, 23860, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Hope Clinical Research
RECRUITING

Canoga Park, California, 91303, United States
Infinite Clinical Research
RECRUITING

Miami, Florida, 33133, United States
Inpatient Research Clinical LLC
RECRUITING

Miami Lakes, Florida, 33014, United States
Inpatient Research Clinical LLC
RECRUITING

Miami Lakes, Florida, 33014, United States
International Research Associates LLC
RECRUITING

Miami, Florida, 33156, United States
Jamaica Hospital Medical Center
RECRUITING

Richmond Hill, New York, 11418, United States
James A Haley Veterans Hospital
RECRUITING

Tampa, Florida, 33612, United States
Javara Research
RECRUITING

Alexandria, Virginia, 22311, United States
Javara Research
RECRUITING

Alexandria, Virginia, 22311, United States
Javara Research
RECRUITING

Alexandria, Virginia, 22311, United States
Javara Research
RECRUITING

Alexandria, Virginia, 22311, United States
Johns Hopkins Univ School of Med
RECRUITING

Baltimore, Maryland, 21287, United States
Johns Hopkins University
RECRUITING

Columbia, Maryland, 21044, United States
Las Vegas Endocrinology
RECRUITING

Henderson, Nevada, 89074, United States
Latin Clinical Trial Center Inc
RECRUITING

San Juan, 00909, Puerto Rico
Long Beach Clinical Trials
RECRUITING

Long Beach, California, 90806, United States
MD Medical Research
RECRUITING

Oxon Hill, Maryland, 20745, United States
Metropolitan Cardiovascular Consultants Llc
RECRUITING

Beltsville, Maryland, 20705, United States
Monroe Biomedical Research
RECRUITING

Monroe, North Carolina, 28112, United States
Monroe Research Llc
RECRUITING

West Monroe, Louisiana, 71291, United States
Morehouse School Of Medicine
RECRUITING

Atlanta, Georgia, 30310, United States
NICRs Research Center
ACTIVE_NOT_RECRUITING

Garden Grove, California, 92844, United States
National Heart Institute
RECRUITING

Beverly Hills, California, 90211, United States
National Research Institute
RECRUITING

Hialeah, Florida, 33013, United States
New Tampa Health
RECRUITING

Tampa, Florida, 33603, United States
NexGen Research
RECRUITING

Lima, Ohio, 45801, United States
North Hills Medical Research Inc
ACTIVE_NOT_RECRUITING

Bedford, Texas, 76021, United States
Omega Clinical Research
RECRUITING

Metairie, Louisiana, 70006, United States
Overlook Medical Center
RECRUITING

Summit, New Jersey, 07901, United States
Parkway Medical Center
RECRUITING

Birmingham, Alabama, 35215, United States
Pharma Tex Research
RECRUITING

Amarillo, Texas, 79106, United States
Plano Primary Care Clinic
RECRUITING

Allen, Texas, 75002-3688, United States
Proactive Clinical Research
RECRUITING

Fort Lauderdale, Florida, 33308, United States
Proactive Clinical Research
ACTIVE_NOT_RECRUITING

Fort Lauderdale, Florida, 33308, United States
Research and Cardiovascular Corp
RECRUITING

Ponce, 00717-1322, Puerto Rico
Robert Wood Johnson Medical School
RECRUITING

New Brunswick, New Jersey, 08901, United States
SW Family Medicine Associates
RECRUITING

Dallas, Texas, 75235, United States
Sinai Ct for Throm Res and Drug Dev
RECRUITING

Baltimore, Maryland, 21209, United States
Sister Life Research Inc
RECRUITING

Hialeah, Florida, 33013, United States
Southern Clin Research Clinic
ACTIVE_NOT_RECRUITING

Zachary, Louisiana, 70791, United States
Stanford Health Care
RECRUITING

Stanford, California, 94305, United States
Stern Cardiovascular Foundation Inc
RECRUITING

Southaven, Mississippi, 38671, United States
Synexus Clinical Research US Inc
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60602, United States
TCV Clinical Studies
RECRUITING

Linwood, Pennsylvania, 19061, United States
The Heart Institute of East Texas
RECRUITING

Lufkin, Texas, 75904, United States
University of Calif Irvine Med Cntr
RECRUITING

Irvine, California, 92660, United States
University of Texas Health Science Ctr
RECRUITING

San Antonio, Texas, 78229-3900, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
VA Caribbean Healthcare System
RECRUITING

San Juan, 00921, Puerto Rico
Valley Clinical Trials Inc
ACTIVE_NOT_RECRUITING

Covina, California, 91723, United States
Vcu Health
RECRUITING

Richmond, Virginia, 23298, United States
Virginia Heart
RECRUITING

Falls Church, Virginia, 22042, United States
Zenith Clinical Research
RECRUITING

Hollywood, Florida, 33021, United States

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