ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

This study looks at whether taking fish oil supplements along with the standard medicine metformin can improve heart health in women with Polycystic Ovary Syndrome (PCOS). The study will include 146 women with PCOS who are overweight and have high blood fats or blood sugar issues…

This study looks at the long-term safety of a drug called pelacarsen in about 600 people with high levels of Lp(a) and established heart disease. Participants have already completed a prior study and will continue taking the open-label drug. The main goal is to track side effects…

This study tests whether a new drug, maridebart cafraglutide, can reduce the risk of heart attacks, strokes, and heart-related death in people who have heart disease and are overweight or obese. About 12,800 adults aged 45 and older will receive either the drug or a placebo, alon…

This early-stage trial is testing whether a new drug called UDP-003 is safe for people. It involves 84 participants: healthy adults and patients who had a heart attack or unstable angina at least a year ago. The study gives single or multiple doses of the drug or a placebo and mo…

This study tests a targeted program to help people at high risk for heart attacks or strokes lower their LDL (bad) cholesterol to recommended levels. About 326 adults with high cholesterol and existing heart or blood vessel disease will be randomly assigned to the program or usua…

This study is testing an investigational drug called CSL300 to see if it can lower the risk of heart attacks and death in people with end-stage kidney disease who are on dialysis. The trial will enroll over 2,300 adults who have both kidney failure and either diabetes or known he…

This study looks at whether telling people their genetic risk for high blood pressure can help them make healthier choices and lower their blood pressure. Researchers will give some participants a special genetic test result plus counseling, while others get standard care. The go…