New drug Kylo-11 aims to tackle stubborn heart disease risk factor

NCT ID NCT07327840

Recruiting now Disease control Sponsor: Kylonova (Xiamen) Biopharma co., LTD. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests Kylo-11, an experimental drug, in 204 adults with heart disease and high levels of lipoprotein(a) – a genetic risk factor for heart attacks and strokes. Participants receive either Kylo-11 or a placebo injection for about a year. The main goal is to see if Kylo-11 safely lowers Lp(a) levels over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Kylo-11
What this could lead to: If it works, this could lead to a new treatment to lower high lipoprotein(a) levels, potentially reducing heart disease risk.
What could go wrong: This is an early phase 2 trial with only 204 people, so results may not confirm benefit. The drug may not lower Lp(a) enough or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

atherosclerotic cardiovascular disease hyperlipidemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIPOPROTEIN DISORDER

Contacts and locations

Locations

Alliance Clinical - Los Angeles
NOT_YET_RECRUITING

Los Angeles, California, 90301, United States
Alliance Clinical - San Diego
NOT_YET_RECRUITING

San Diego, California, 92115, United States
Alliance Clinical Las Vegas Excel Clinical Research
NOT_YET_RECRUITING

Las Vegas, Nevada, 89109, United States
Arrow Clinical Trials LLC
NOT_YET_RECRUITING

Daytona Beach, Florida, 32117, United States
Beijing Anzhen Hospital
RECRUITING

Beijing, China
Beijing Chao-Yang Hospital, Capital Medical University
RECRUITING

Beijing, China
Care Access-Lake Charles, LA
NOT_YET_RECRUITING

Lake Charles, Louisiana, 70601, United States
Central Hospital Affiliated to Shandong First Medical University
RECRUITING

Jinan, China
Centricity Research - Columbus
NOT_YET_RECRUITING

Columbus, Georgia, 31904, United States
Centricity Research d/b/a Lucas Research, Inc.
RECRUITING

Morehead City, North Carolina, 28557, United States
China-Japan Union Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, China
Chongqing University Three Gorges Hospital
RECRUITING

Chongqing, China
Clinical Research of West Florida (CRWF) - Clearwater
RECRUITING

Clearwater, Florida, 33765, United States
Clinical Research of West Florida (CRWF) - Tampa
RECRUITING

Tampa, Florida, 33606, United States
Daqingshi People's Hospital
RECRUITING

Daqing, China
Emory Healthcare-Emory Heart & Vascular Center - Executive Park
NOT_YET_RECRUITING

Atlanta, Georgia, 30324, United States
Excel Medical Trials - Flourish Research
NOT_YET_RECRUITING

Boca Raton, Florida, 33434, United States
FOMAT - Comprehensive Cardiovascular Care-Santa Maria California
NOT_YET_RECRUITING

Santa Maria, California, 93454, United States
Family Research Centers - Hialeah
RECRUITING

Hialeah, Florida, 33012, United States
Family Research and Healthcare Center Inc.
RECRUITING

Doral, Florida, 33126, United States
Guangzhou First People's Hospital
NOT_YET_RECRUITING

Guangzhou, China
Hainan Third People's Hospital
RECRUITING

Sanya, China
Jacksonville Center for Clinical Research
RECRUITING

Jacksonville, Florida, 32216, United States
Lishui Central Hospital
RECRUITING

Lishui, China
Luoyang Third People's Hospital
RECRUITING

Luoyang, China
Nanchang People's Hospital
RECRUITING

Nanchang, China
Nanyang Medical College First Affiliated Hospital
RECRUITING

Nanyang, China
Peking University First Hospital
RECRUITING

Beijing, Beijing Municipality, 100034, China
People's Hospital of Zhengzhou
RECRUITING

Zhengzhou, China
Qilu Hospital of Shandong University
RECRUITING

Jinan, China
Shaanxi Provincial People's Hospital
RECRUITING

Xi'an, China
Shanghai Putuo District Central Hospital
NOT_YET_RECRUITING

Shanghai, China
Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital
NOT_YET_RECRUITING

Chengdu, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
RECRUITING

Guangzhou, China
TEDA International Cardiovascular Hospital
RECRUITING

Tianjin, China
The Affiliated Hospital of Southwest Medical University
NOT_YET_RECRUITING

Luzhou, China
The Affiliated Hospital of Xuzhou Medical College
RECRUITING

Xuzhou, China
The First Affiliated Hospital of Baotou Medical College
RECRUITING

Baotou, China
The First Affiliated Hospital of Dali University
RECRUITING

Dali, China
The First Affiliated Hospital of Henan University of Science and Technology
RECRUITING

Luoyang, China
The First Affiliated Hospital of Ningbo University
RECRUITING

Ningbo, China
The First Affiliated Hospital of University of South China
RECRUITING

Hengyang, China
The First Affiliated Hospital of Xi'an Jiaotong University
NOT_YET_RECRUITING

Xi'an, China
The First Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, China
The First Hospital of Jilin University
RECRUITING

Jilin City, China
The First Hospital of Qiqihar
NOT_YET_RECRUITING

Qiqihar, China
The First People's Hospital of Changde
NOT_YET_RECRUITING

Changde, China
The Fourth Affiliated Hospital of Harbin Medical University
RECRUITING

Harbin, China
The Second Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITING

Chongqing, China
The Second Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, China
The Third Xiangya Hospital of Central South University
NOT_YET_RECRUITING

Changsha, China
Tianjin People's Hospital
RECRUITING

Tianjin, China
Tongji Medical College of Hust Tongji Hospital
RECRUITING

Wuhan, China
Universal Axon Clinical Research
NOT_YET_RECRUITING

Miami, Florida, 33166, United States
Xiamen Cardiovascular Hospital Xiamen University
RECRUITING

Xiamen, China
Yan'an University Xianyang Hospital
RECRUITING

Xianyang, China
Yuncheng Central Hospital of Shanxi Province
RECRUITING

Yuncheng, China
Zhongshan Hospital Fudan University, Qingpu Branch
RECRUITING

Shanghai, China
Zibo Central Hospital
RECRUITING

Zibo, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.