ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

This early-stage trial tests whether an experimental drug called UDP-003 is safe in healthy volunteers and people with heart disease. Researchers will give single or multiple doses of the drug or a placebo and monitor for side effects. The study includes 84 participants and is th…

This study tests whether a digital support program (called DEEPER) helps heart patients maintain their health after completing cardiac rehab. About 306 adults with heart disease or heart failure will be split into two groups: one gets standard follow-up care, the other gets stand…

This phase 2 trial tests Kylo-11, an experimental drug, in 204 adults with heart disease and high levels of lipoprotein(a) – a genetic risk factor for heart attacks and strokes. Participants receive either Kylo-11 or a placebo injection for about a year. The main goal is to see i…

This phase 3 study is testing whether a new drug called maridebart cafraglutide (MariTide) can reduce the risk of heart attacks, strokes, and death in people with heart disease who are overweight or obese. About 12,800 participants will receive either the drug or a placebo, added…

This study compares two cholesterol-lowering strategies in about 1,950 adults with chronic kidney disease and heart or blood vessel disease. One group gets a moderate-dose statin plus ezetimibe, the other gets a high-dose statin alone. The goal is to see if the combo is just as g…

This study is for people with high levels of Lp(a), a genetic risk factor for heart disease, who have already completed a prior pelacarsen trial. It will give them continued access to the drug while monitoring long-term safety and how well it keeps Lp(a) levels low. About 600 par…

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This Phase 3 trial is testing an injectable drug called HRS9531 in about 9,200 people with atherosclerotic cardiovascular disease (hardened arteries). The goal is to see if it can lower the chance of major heart problems like heart attack, stroke, or death. Participants receive e…

This phase 3 trial is testing an experimental daily pill called AZD0780 in about 15,100 people who have had a heart attack, stroke, or are at high risk for one. The drug works by blocking a protein called PCSK9 to lower cholesterol. Researchers want to see if it reduces the chanc…

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This study tests whether a targeted lipid optimization program—combining clinic visits and virtual sessions—helps high-risk heart disease patients in Abu Dhabi achieve better LDL cholesterol control. About 326 adults with atherosclerotic cardiovascular disease will be randomly as…

This study tests whether a smartphone app can help people with atherosclerosis (hardening of the arteries) stick to their new statin medication. About 250 adults who need to start a high-dose statin will either receive standard care or standard care plus the app. The main goal is…

This Phase 3 trial tests olpasiran, a drug that lowers lipoprotein(a), a genetic risk factor for heart disease. About 406 adults with stable heart disease and high Lp(a) will receive either olpasiran or a placebo. The main goal is to see if olpasiran reduces non-calcified plaque …

This study tests a digital health program called Corrie Lipids in about 1,000 adults with high LDL cholesterol and heart disease risk. The program includes a smartphone app for tracking cholesterol, medication reminders, and education, plus training for doctors to improve cholest…

This study tests whether starting cholesterol-lowering treatment in the emergency department can help prevent heart attacks and strokes in people at risk. About 130 adults aged 40-75 who are in the ER for possible heart issues will receive guideline-based care. The goal is to low…

This study tests whether adding inclisiran (a twice-yearly injection) to standard care lowers LDL cholesterol more than standard care alone in 520 patients who recently had a heart attack, stroke, or urgent heart procedure. Participants are randomly assigned to receive inclisiran…

This study is testing whether metformin, a common diabetes medicine, can reduce the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,410 participants will receive either metformin or a placebo. The…

This study looks at whether taking fish oil and/or metformin for 12 months can improve heart health in women with Polycystic Ovary Syndrome (PCOS). PCOS raises the risk of heart disease and diabetes. The trial will enroll 146 women with PCOS who are overweight and have high blood…

This study tests whether a digital heart health program (a web app, online classes, and special foods) added to usual care can lower cholesterol and reduce heart attacks in people with heart disease or risk factors. About 1,100 participants will be randomly assigned to the progra…

This study uses a survey to find out how well people with existing heart disease understand their risk factors and their chances of having another heart problem. Researchers will compare answers from 200 women and men to see if there are differences. The goal is to learn where aw…

This study will use advanced PET/MRI scans to see how exercise affects brain activity and blood vessel inflammation in 10 people with PTSD who also have heart disease or risk factors. Participants will follow a gradually increasing exercise program. The goal is to understand whet…

This study looks at 1000 adults (ages 40-80) with high cholesterol but no heart symptoms. Researchers want to see if using special scans of the neck and heart arteries can find hidden plaque better than the standard risk calculator. The goal is to improve early detection and prev…

This study tests whether giving young and middle-aged adults with high blood pressure a personalized genetic risk score helps them lower their blood pressure and adopt healthier habits. 300 participants will either receive standard care or get their genetic risk results along wit…