ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

This early-stage study tested the safety of an experimental oral drug called AZD4144 in people with both heart and kidney disease. Twenty-nine participants took either the drug or a placebo pill daily for 28 days. The main goal was to see if the drug was safe and to measure its e…

This study tested if starting two cholesterol-lowering drugs together works better than one for people at very high risk of heart attack or stroke. It compared the combination of ezetimibe and atorvastatin against atorvastatin alone in 137 patients. The main goal was to see which…

This large, completed Phase 3 trial tested whether a new drug called obicetrapib could help people with high cholesterol and heart disease who weren't getting enough benefit from their current medications. Over 2,500 participants took either the new pill or a placebo (a dummy pil…

This study used health insurance records from nearly 50,000 people to compare two common diabetes medications, tirzepatide and sitagliptin. The goal was to see which drug is more effective at preventing serious heart problems like heart attacks and strokes in people who have both…

This study tested whether aiming for very low 'bad' cholesterol (LDL) levels is better than standard low levels for people with heart disease. Over 3,000 participants were randomly assigned to either a very low target or a standard target, using either a single cholesterol drug o…

This study tested whether an experimental drug called AZD0780 could lower blood pressure in people with heart disease or high risk for it. Researchers measured blood pressure changes over 24 hours in 202 adults who already had high cholesterol. Participants took either the drug o…

This study aimed to understand how common a specific type of blood fat, called lipoprotein(a) or Lp(a), is in people who have had heart disease. Researchers measured Lp(a) levels in over 39,000 participants with a history of heart problems. The goal was to see how many people had…

This study was a survey of 608 heart and kidney specialists. Its purpose was to understand how these doctors think about and use a specific blood test (hsCRP) to detect hidden inflammation in patients with combined heart and kidney diseases. The goal was to gather real-world info…